[Asymptomatic kidney tumors in elderly patients: Review of treatment approaches in Russia and Western countries.]

Analyzed and evaluated the results of recent research on active observation strategies in North America and Europe. There are enough grounds for a more active implementation and use of this approach, which is permissible in a strictly selected category of patients, namely in elderly patients. In Russia at the moment, a personalized approach to treatment is underdeveloped. Patients over 60-65 years old are a significant group of patients with kidney tumors. In determining the tactics of maintaining these patients, it is important to understand that this contingent has a greater risk of death from comorbidities than the relatively low risk of death from kidney cancer. The improvement of modern diagnostic methods and the introduction of screening programs has led to a significant increase in the frequency of detection of small kidney tumors in elderly patients. The results of studies comparing radical approaches to treatment and observation suggest the widespread adoption of a strategy for actively monitoring asymptomatic kidney tumors in the elderly in the Russian oncological practice.

The role of inflammatory chemokines in lymphoid neoorganogenesis in breast cancer.

The expression profiling analysis of inflammatory chemokines and their receptors in newly formed lymph nodes in breast cancer was carried out. The analysis revealed the increase in expression of the genes CCL16, XCR1, CYFIP2, TNFSF14 and the reduction in expression of chemokine ligands CXCL5 and CXCL12 in tertiary lymphoid organs. The obtained results allow us to suggest that the process of induction of lymph nodes neogenesis is identical (in its key mechanisms) to the process of lymphoid tissue neogenesis in autoimmune diseases and in some infections, but may have different triggers.