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1.
BMC Musculoskelet Disord ; 21(1): 759, 2020 Nov 18.
Article in English | MEDLINE | ID: mdl-33208124

ABSTRACT

BACKGROUND: Legg-Calvé-Perthes (LCP) is a common orthopedic childhood disease that causes a deformity of the femoral head and to an adaptive deformity of the acetabulum. The altered joint biomechanics can result in early joint degeneration that requires total hip arthroplasty. In 2002, Ganz et al. introduced the femoral head reduction osteotomy (FHRO) as a direct joint-preserving treatment. The procedure remains one of the most challenging in hip surgery. Computer-based 3D preoperative planning and patient-specific navigation instruments have been successfully used to reduce technical complexity in other anatomies. The purpose of this study was to report the first results in the treatment of 6 patients to investigate whether our approach is feasible and safe. METHODS: In this retrospective pilot study, 6 LCP patients were treated with FHRO in multiple centers between May 2017 and June 2019. Based on patient-specific 3D-models of the hips, the surgeries were simulated in a step-wise fashion. Patient-specific instruments tailored for FHRO were designed, 3D-printed and used in the surgeries for navigating the osteotomies. The results were assessed radiographically [diameter index, sphericity index, Stulberg classification, extrusion index, LCE-, Tönnis-, CCD-angle and Shenton line] and the time and costs were recorded. Radiologic values were tested for normal distribution using the Shapiro-Wilk test and for significance using Wilcoxon signed-rank test. RESULTS: The sphericity index improved postoperatively by 20% (p = 0.028). The postoperative diameter of the femoral head differed by only 1.8% (p = 0.043) from the contralateral side and Stulberg grading improved from poor coxarthrosis outcome to good outcome (p = 0.026). All patients underwent acetabular reorientation by periacetabular osteotomy. The average time (in minutes) for preliminary analysis, computer simulation and patient-specific instrument design was 63 (±48), 156 (±64) and 105 (±68.5), respectively. CONCLUSION: The clinical feasibility of our approach to FHRO has been demonstrated. The results showed significant improvement compared to the preoperative situation. All operations were performed by experienced surgeons; nevertheless, three complications occurred, showing that FHRO remains one of the most complex hip surgeries even with computer assistance. However, none of the complications were directly related to the simulation or the navigation technique.


Subject(s)
Femur Head , Legg-Calve-Perthes Disease , Acetabulum/diagnostic imaging , Acetabulum/surgery , Child , Computer Simulation , Femur Head/diagnostic imaging , Femur Head/surgery , Hip Joint/diagnostic imaging , Hip Joint/surgery , Humans , Legg-Calve-Perthes Disease/diagnostic imaging , Legg-Calve-Perthes Disease/surgery , Osteotomy , Pilot Projects , Radiography , Retrospective Studies , Treatment Outcome
2.
JBJS Case Connect ; 9(3): e0321, 2019.
Article in English | MEDLINE | ID: mdl-31441832

ABSTRACT

CASE: A 10-year-old girl presented after possible occult hip trauma, with shortening of the leg being the initial clinical symptom, followed by motion-dependent pain. She had limited external rotation in extension with anterior apprehension. Radiographically, the deformity was an anterior tilt of the epiphysis with coxa vara. Surgery included surgical dislocation using a retinacular flap for the anterior open wedge femoral neck osteotomy for extension and posterior translation, with an excellent 4.5-year clinical outcome. CONCLUSIONS: Caput flexum is a rare deformity with localized premature closure of the anterior growth plate of the hip. To avoid secondary impingement, an osteotomy was successfully placed close to the deformity.


Subject(s)
Hip Injuries/pathology , Hip Joint/pathology , Skiing/injuries , Child , Female , Hip Injuries/diagnostic imaging , Hip Injuries/surgery , Hip Joint/diagnostic imaging , Hip Joint/surgery , Humans , Osteotomy
3.
J Child Orthop ; 11(2): 131-137, 2017 Apr.
Article in English | MEDLINE | ID: mdl-28529662

ABSTRACT

NEW PATHOPHYSIOLOGICAL INSIGHTS: Based on improved knowledge of the vascular supply of the proximal femur, a safe surgical dislocation of the hip joint was established allowing direct insights to the pathomorphological malfunctioning of the joint. One insight was that slipped capital femoral epiphysis (SCFE) impingement leads to substantial damage of the chondrolabral rim area, even in the presence of minor slips. A further surgical development was the extended retinacular flap allowing for correction of the deformity with calculable risk for iatrogenic necrosis. CONSECUTIVE SURGICAL CONCEPT: In 20 years of experience, a treatment concept for SCFE could be established which replaces classic pinning in situ and indirect correction of the deformity with subcapital re-alignment when the physis is still open, with true femoral neck osteotomy for hips with closed physis. Pinning in situ still has a place in minor slips but should be combined with open or arthroscopic recreation of an anterior metaphyseal waisting. UNEXPECTED COMPLICATION: Loss of joint stability is a rare complication of anatomic re-alignment. It can be disease-related when the impingement has induced severe destruction of acetabular cartilage. It can be related to the surgical procedure, especially when the neck was excessively shortened and refixation of the trochanter was not advanced. Finally, in cases with severe and long-lasting deformity, the acetabulum may undergo adaptive flattening, being the cause of joint destabilisation with the correction of the deformity. Advancement of the greater trochanter and/or peri-acetabular osteotomy may be discussed to restabilise the joint.

4.
Bone Joint J ; 99-B(1): 16-21, 2017 Jan.
Article in English | MEDLINE | ID: mdl-28053252

ABSTRACT

AIMS: Several studies have reported the safety and efficacy of subcapital re-alignment for patients with slipped capital femoral epiphysis (SCFE) using surgical dislocation of the hip and an extended retinacular flap. Instability of the hip and dislocation as a consequence of this surgery has only recently gained attention. We discuss this problem with some illustrative cases. MATERIALS AND METHODS: We explored the literature on the possible pathophysiological causes and surgical steps associated with the risk of post-operative instability and articular damage. In addition, we describe supplementary steps that could be used to avoid these problems. RESULTS: The causes of instability may be divided into three main groups: the first includes causes directly related to SCFE (acetabular labral damage, severe abrasion of the acetabular cartilage, flattening of the acetabular roof and a bell-shaped deformity of the epiphysis); the second, causes not related to the SCFE (acetabular orientation and poor quality of the soft tissues); the third, causes directly related to the surgery (capsulotomy, division of the ligamentum teres, shortening of the femoral neck, pelvi-trochanteric impingement, previous proximal femoral osteotomy and post-operative positioning of the leg). CONCLUSION: We present examples drawn from our clinical practice, as well as possible ways of reducing the risks of these complications, and of correcting them if they happen. Cite this article: Bone Joint J 2017;99-B:16-21.


Subject(s)
Hip Joint/surgery , Joint Instability/etiology , Postoperative Complications/etiology , Slipped Capital Femoral Epiphyses/surgery , Acetabulum/diagnostic imaging , Acetabulum/injuries , Bone Malalignment/prevention & control , Cartilage, Articular/diagnostic imaging , Cartilage, Articular/injuries , Femoracetabular Impingement/diagnostic imaging , Femoracetabular Impingement/etiology , Hip Joint/diagnostic imaging , Humans , Intraoperative Complications/diagnostic imaging , Intraoperative Complications/etiology , Joint Instability/diagnostic imaging , Postoperative Complications/diagnostic imaging , Slipped Capital Femoral Epiphyses/diagnostic imaging
5.
Bone Joint J ; 97-B(5): 636-41, 2015 May.
Article in English | MEDLINE | ID: mdl-25922457

ABSTRACT

The modified Smith-Petersen and Kocher-Langenbeck approaches were used to expose the lateral cutaneous nerve of the thigh and the femoral, obturator and sciatic nerves in order to study the risk of injury to these structures during the dissection, osteotomy, and acetabular reorientation stages of a Bernese peri-acetabular osteotomy. Injury of the lateral cutaneous nerve of thigh was less likely to occur if an osteotomy of the anterior superior iliac spine had been carried out before exposing the hip. The obturator nerve was likely to be injured during unprotected osteotomy of the pubis if the far cortex was penetrated by > 5 mm. This could be avoided by inclining the osteotome 45° medially and performing the osteotomy at least 2 cm medial to the iliopectineal eminence. The sciatic nerve could be injured during the first and last stages of the osteotomy if the osteotome perforated the lateral cortex of ischium and the ilio-ischial junction by > 10 mm. The femoral nerve could be stretched or entrapped during osteotomy of the pubis if there was significant rotational or linear displacement of the acetabulum. Anterior or medial displacement of < 2 cm and lateral tilt (retroversion) of < 30° were safe margins. The combination of retroversion and anterior displacement could increase tension on the nerve. Strict observation of anatomical details, proper handling of the osteotomes and careful manipulation of the acetabular fragment reduce the neurological complications of Bernese peri-acetabular osteotomy.


Subject(s)
Hip/innervation , Intraoperative Complications/prevention & control , Osteotomy , Peripheral Nerve Injuries/prevention & control , Acetabulum , Adolescent , Adult , Cadaver , Humans , Male , Middle Aged , Osteotomy/methods , Risk Management , Young Adult
6.
Dis Esophagus ; 28(4): 305-11, 2015.
Article in English | MEDLINE | ID: mdl-24612509

ABSTRACT

Antireflux surgery with a magnetic sphincter augmentation device (MSAD) restores the competency of the lower esophageal sphincter with a device rather than a tissue fundoplication. As a regulated device, safety information from the published clinical literature can be supplemented by tracking under the Safe Medical Devices Act. The aim of this study was to examine the safety profile of the MSAD in the first 1000 implanted patients. We compiled safety data from all available sources as of July 1, 2013. The analysis included intra/perioperative complications, hospital readmissions, procedure-related interventions, reoperations, and device malfunctions leading to injury or inability to complete the procedure. Over 1000 patients worldwide have been implanted with the MSAD at 82 institutions with median implant duration of 274 days. Event rates were 0.1% intra/perioperative complications, 1.3% hospital readmissions, 5.6% endoscopic dilations, and 3.4% reoperations. All reoperations were performed non-emergently for device removal, with no complications or conversion to laparotomy. The primary reason for device removal was dysphagia. No device migrations or malfunctions were reported. Erosion of the device occurred in one patient (0.1%). The safety analysis of the first 1000 patients treated with MSAD for gastroesophageal reflux disease confirms the safety of this device and the implantation technique. The overall event rates were low based on data from 82 institutions. The MSAD is a safe therapeutic option for patients with chronic, uncomplicated gastroesophageal reflux disease.


Subject(s)
Esophageal Sphincter, Lower/surgery , Gastroesophageal Reflux/surgery , Magnetic Field Therapy/instrumentation , Prostheses and Implants/statistics & numerical data , Deglutition Disorders/epidemiology , Deglutition Disorders/etiology , Device Removal/statistics & numerical data , Equipment Failure Analysis , Equipment Safety , Humans , Patient Readmission/statistics & numerical data , Postoperative Complications/epidemiology , Prostheses and Implants/adverse effects , Reoperation/statistics & numerical data
7.
Bone Joint J ; 96-B(1): 5-18, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24395304

ABSTRACT

The use of joint-preserving surgery of the hip has been largely abandoned since the introduction of total hip replacement. However, with the modification of such techniques as pelvic osteotomy, and the introduction of intracapsular procedures such as surgical hip dislocation and arthroscopy, previously unexpected options for the surgical treatment of sequelae of childhood conditions, including developmental dysplasia of the hip, slipped upper femoral epiphysis and Perthes' disease, have become available. Moreover, femoroacetabular impingement has been identified as a significant aetiological factor in the development of osteoarthritis in many hips previously considered to suffer from primary osteoarthritis. As mechanical causes of degenerative joint disease are now recognised earlier in the disease process, these techniques may be used to decelerate or even prevent progression to osteoarthritis. We review the recent development of these concepts and the associated surgical techniques.


Subject(s)
Bone Diseases, Developmental/surgery , Hip Joint/surgery , Arthroscopy/methods , Bone Diseases, Developmental/diagnostic imaging , Femur Head/surgery , Femur Neck/surgery , Hip Dislocation, Congenital/diagnostic imaging , Hip Dislocation, Congenital/surgery , Humans , Legg-Calve-Perthes Disease/surgery , Osteoarthritis, Hip/prevention & control , Osteotomy/methods , Radiography , Slipped Capital Femoral Epiphyses/diagnostic imaging , Slipped Capital Femoral Epiphyses/surgery
8.
Osteoarthritis Cartilage ; 21(4): 544-50, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23337290

ABSTRACT

OBJECTIVES: Femoroacetabular impingement is proposed to cause early osteoarthritis (OA) in the non-dysplastic hip. We previously reported on the prevalence of femoral deformities in a young asymptomatic male population. The aim of this study was to determine the prevalence of both femoral and acetabular types of impingement in young females. METHODS: We conducted a population-based cross-sectional study of asymptomatic young females. All participants completed a set of questionnaires and underwent clinical examination of the hip. A random sample was subsequently invited to obtain magnetic resonance images (MRI) of the hip. All MRIs were read for cam-type deformities, increased acetabular depths, labral lesions, and impingement pits. Prevalence estimates of cam-type deformities and increased acetabular depths were estimated, and relationships between deformities and signs of joint damage were examined using logistic regression models. RESULTS: The study included 283 subjects, and 80 asymptomatic females with a mean age of 19.3 years attended MRI. Fifteen showed some evidence of cam-type deformities, but none were scored to be definite. The overall prevalence was therefore 0% [95% confidence interval (95% CI) 0-5%]. The prevalence of increased acetabular depth was 10% (95% CI 5-19). No association was found between increased acetabular depth and decreased internal rotation of the hip. Increased acetabular depth was not associated with signs of labral damage. CONCLUSIONS: Definite cam-type deformities in women are rare compared to men, whereas the prevalence of increased acetabular depth is higher, suggesting that femoroacetabular impingement has different gender-related biomechanical mechanisms.


Subject(s)
Femoracetabular Impingement/epidemiology , Acetabulum/pathology , Adolescent , Cross-Sectional Studies , Female , Femoracetabular Impingement/diagnosis , Femoracetabular Impingement/pathology , Femoracetabular Impingement/physiopathology , Hip Joint/physiopathology , Humans , Magnetic Resonance Imaging , Male , Prevalence , Range of Motion, Articular , Sex Factors , Switzerland/epidemiology , Young Adult
9.
Dis Esophagus ; 26(8): 755-65, 2013.
Article in English | MEDLINE | ID: mdl-22882487

ABSTRACT

Gastroesophageal reflux disease (GERD) can be difficult to diagnose - symptoms alone are often not enough, and thus, objective testing is often required. GERD is a manifestation of pathologic levels of reflux into the esophagus of acidic, nonacidic, and/or bilious gastric content. However, in our current evidence-based knowledge approach, we only have reasonable outcome data in regards to acid reflux, as this particular type of refluxate predictably causes symptoms and mucosal damage, which improves with medical or surgical therapy. While there are data suggesting that nonacid reflux may be responsible for ongoing symptoms despite acid suppression in some patients, outcome data about this issue are limited. Therefore, this working group believes that it is essential to confirm the presence of acid reflux in patients with 'refractory' GERD symptoms or extraesophageal symptoms thought to be caused by gastroesophageal reflux before an escalation of antireflux therapy is considered. If patients do not have pathologic acid reflux off antisecretory therapy, they are unlikely to have clinically significant nonacid or bile reflux. Patients who do not have pathologic acid gastroesophageal reflux parameters on ambulatory pH monitoring then: (i) could attempt to discontinue antisecretory medications like proton pump inhibitors and H2-receptor antagonists (which are expensive and which carry risks - i.e. C. diff, etc.); (ii) may undergo further evaluation for other causes of their esophageal symptoms (e.g. functional heartburn or chest pain, eosinophilic esophagitis, gastroparesis, achalasia, other esophageal motor disorders); and (iii) can be referred to an ear, nose, and throat/pulmonary/allergy physician for assessment of non-GERD causes of their extraesophageal symptoms.


Subject(s)
Advisory Committees , Esophageal pH Monitoring/instrumentation , Gastroesophageal Reflux/diagnosis , Esophageal Motility Disorders/diagnosis , Esophagus/physiopathology , Gastroesophageal Reflux/drug therapy , Humans , Hydrogen-Ion Concentration , Proton Pump Inhibitors/therapeutic use , Wireless Technology/instrumentation
10.
Eur Cell Mater ; 21: 243-58, 2011 Mar 15.
Article in English | MEDLINE | ID: mdl-21409754

ABSTRACT

Hip resurfacing arthroplasty (HRA) is a concept of hip replacement that allows treating young active patients with a femoral bone preserving procedure. The proposed advantages of resuming an active lifestyle with increased frequency and duration of sports activities have been shown to be realistic. The 30-year cost-effectiveness in young male patients has been shown to be higher in resurfacing compared to conventional total hip replacement (THA). However, prognosticators of an inferior outcome have also been identified. The most important patient related factors are secondary osteoarthritis as the indication for surgery such as post-childhood hip disorders or AVN, female gender, smaller component sizes and older age (>65 years for males and >55 years for females). In addition, surgical technique (approach and cementing technique) and component design are also important determinant factors for the risk of failure. Moreover, concerns have surfaced with respect to high metal ion concentrations and metal ion hypersensitivities. In addition, the presumed ease of revising HRA has not reflected in improved or equal survivorship in comparison to a primary THA. This highlights the importance of identifying patient-, surgery-, and implant-related prognosticators for success or failure of HRA. Rather than vilifying the concept of hip resurfacing, detailed in depth analysis should be used to specify indications and improve implant design and surgical techniques.


Subject(s)
Arthroplasty, Replacement, Hip/trends , Hip Prosthesis , Humans , Prosthesis Failure , Quality of Life , Treatment Outcome
12.
Clin Orthop Relat Res ; 469(6): 1728-34, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21128036

ABSTRACT

BACKGROUND: The iliocapsularis muscle is a little known muscle overlying the anterior hip capsule postulated to function as a stabilizer of dysplastic hips. Theoretically, this muscle would be hypertrophied in dysplastic hips and, conversely, atrophied in stable and well-constrained hips. However, these observations have not been confirmed and the true function of this muscle remains unknown. QUESTIONS/PURPOSES: We quantified the anatomic dimensions and degree of fatty infiltration of the iliocapsularis muscle and compared the results for 45 hips with deficient acetabular coverage (Group I) with 40 hips with excessive acetabular coverage (Group II). PATIENTS AND METHODS: We used MR arthrography to evaluate anatomic dimensions (thickness, width, circumference, cross-sectional area [CSA], and partial volume) and the amount of fatty infiltration. RESULTS: We observed increased thickness, width, circumference, CSA, and partial volume of the iliocapsularis muscle in Group I when compared with Group II. Additionally, hips in Group I had a lower prevalence of fatty infiltration compared with those in Group II. The iliocapsularis muscle typically was hypertrophied, and there was less fatty infiltration in dysplastic hips compared with hips with excessive acetabular coverage. CONCLUSION: These observations suggest the iliocapsularis muscle is important for stabilizing the femoral head in a deficient acetabulum. This muscle serves as an anatomic landmark when performing a periacetabular osteotomy. Additionally, preoperative evaluation of morphologic features of the muscle can be used as an adjunct for decision making when treating patients with borderline hip dysplasia or femoroacetabular impingement.


Subject(s)
Arthroplasty, Replacement, Hip/instrumentation , Hip Dislocation, Congenital/surgery , Hip Prosthesis , Muscle, Skeletal/physiopathology , Adolescent , Adult , Arthrography/methods , Female , Hip Dislocation, Congenital/diagnosis , Hip Dislocation, Congenital/physiopathology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Muscle, Skeletal/surgery , Prosthesis Design , Treatment Outcome , Young Adult
13.
Osteoarthritis Cartilage ; 18(3): 365-71, 2010 Mar.
Article in English | MEDLINE | ID: mdl-19833251

ABSTRACT

OBJECTIVE: To determine the performance of a newly developed examination chair as compared with the clinical standard of assessing internal rotation (IR) of the flexed hip with a goniometer. METHODS: The examination chair allowed measurement of IR in a sitting position simultaneously in both hips, with hips and knees flexed 90 degrees, lower legs hanging unsupported and a standardized load of 5 kg applied to both ankles using a bilateral pulley system. Clinical assessment of IR was performed in supine position with hips and knees flexed 90 degrees using a goniometer. Within the framework of a population-based inception cohort study, we calculated inter-observer agreement in two samples of 84 and 64 consecutive, unselected young asymptomatic males using intra-class correlation coefficients (ICC) and determined the correlation between IR assessed with examination chair and clinical assessment. RESULTS: Inter-observer agreement was excellent for the examination chair (ICC right hip, 0.92, 95% confidence interval [CI] 0.89-0.95; ICC left hip, 0.90, 95% CI 0.86-0.94), and considerably higher than that seen with clinical assessment (ICC right hip, 0.65, 95% CI 0.49-0.77; ICC left hip, 0.69, 95% CI 0.54-0.80, P for difference in ICC between examination chair and clinical assessment

Subject(s)
Hip Joint/physiology , Hip/anatomy & histology , Osteoarthritis, Hip/physiopathology , Range of Motion, Articular , Biomechanical Phenomena , Equipment Design , Equipment and Supplies , Humans , Male , Reference Values , Rotation , Switzerland , Young Adult
14.
Orthopade ; 38(5): 394-401, 2009 May.
Article in German | MEDLINE | ID: mdl-19407990

ABSTRACT

Femoroacetabular impingement (FAI), a recently proposed mechanical concept regarding the development of osteoarthritis (OA) of the hip, is gaining increased acceptance. Both osseous deformity and use of the hip may result in hip damage. Osseous deformities are seen on the acetabular (pincer) or the femoral (cam) side of the hip, leading to characteristic alterations of the acetabular rim. Cam FAI is found in 20-30-year-old athletic men, revealing deep cartilage avulsions from the acetabular rim while the labrum is frequently intact. In pincer FAI, found in 30-40-year-old women, the labrum is frequently significantly destroyed with only minor damage to the acetabular rim. Professional or athletic impact activities can trigger even mild FAI deformities to become symptomatic. For some FAI deformities, the etiologies are known, but for most of them the exact causes are unknown. An improved understanding of the etiology of FAI and its role in the development of hip OA might lead to a reduction in the prevalence of so-called primary OA of the hip.


Subject(s)
Acetabulum/pathology , Hip Joint/pathology , Joint Diseases/diagnosis , Joint Diseases/therapy , Osteoarthritis, Hip/diagnosis , Osteoarthritis, Hip/therapy , Humans , Joint Diseases/etiology , Osteoarthritis, Hip/complications
15.
Osteoarthritis Cartilage ; 17(4): 539-46, 2009 Apr.
Article in English | MEDLINE | ID: mdl-18838280

ABSTRACT

OBJECTIVE: Outcome in osteochondral allografting is limited by the immunological incompatibility of the grafted tissue. Based on a resistance of chondrocytes to photodynamic therapy in cell culture it is proposed that 5-aminolevulinic acid-based photodynamic therapy (5-ALA-PDT) might be used to inactivate bone while maintaining viability of chondrocytes and thus immunomodulate bone selectively. METHODS: Chondrocytes and osteoblasts from porcine humeral heads were either isolated (cell culture) or treated in situ (tissue culture). To quantify cytotoxic effects of 5-ALA-PDT (0-20 J/cm(2), 100 mW/cm(2)) an (3-(4,5-dimethylthiazol-2-yl)-2,5-di-phenyltetrazolium bromide) (MTT)-assay was used in cell culture and in situ hybridization in tissue culture to assess metabolic active cells (functional osteoblasts: col alpha(1)(I) mRNA, functional chondrocytes: col alpha(1)(II) mRNA). RESULTS: In cell culture, survival after 5-ALA-PDT was significantly higher for chondrocytes (5 J/cm(2): 87+/-12% compared to untreated cells) than for osteoblasts (5J/cm(2): 12+/-11%). In tissue culture, the percentage of functional chondrocytes in cartilage showed a decrease after 5-ALA-PDT (direct fixation: 92+/-2%, 20 J/cm(2): 35+/-15%; P<0.0001). A significant decrease in the percentage of bone surfaces covered by functional osteoblasts was observed in freshly harvested (31+/-3%) compared to untreated tissues maintained in culture (11+/-4%, P<0.0001), with no further decrease after 5-ALA-PDT. CONCLUSION: Chondrocytes were more resistant to 5-ALA-PDT than osteoblasts in cell culture, while in tissue culture a loss of functional chondrocytes was observed after 5-ALA-PDT. Since osteoblasts - but not chondrocytes - were sensitive to the tissue culture conditions, devitalized bone with functional cartilage might already be achieved by applying specific tissue culture conditions even without 5-ALA-PDT.


Subject(s)
Aminolevulinic Acid/pharmacology , Chondrocytes/drug effects , Osteoblasts/drug effects , Photochemotherapy , Photosensitizing Agents/pharmacology , Animals , Cartilage, Articular/cytology , Cartilage, Articular/drug effects , Cartilage, Articular/radiation effects , Cell Survival/drug effects , Cell Survival/radiation effects , Cells, Cultured , Chondrocytes/radiation effects , Feasibility Studies , Osteoblasts/radiation effects , Sus scrofa , Tissue Culture Techniques
16.
Nervenarzt ; 80(4): 475-84, 2009 Apr.
Article in German | MEDLINE | ID: mdl-19039572

ABSTRACT

Dissociative seizures, albeit a psychiatric symptom, are encountered only rarely in psychiatric settings and more often in a neurologic context. Due to the clinical similarity of these dissociative states with neurological symptoms, optimal treatment is often hampered and lies on the border between psychiatric and neurologic approaches. Diagnostic work-up as well as the therapy may prove to be complex and tedious, partly due to the underlying psychopathology of these patients. Management by neurologists, psychiatrists, and primary care physicians should take into account specific therapeutic and diagnostic guidelines aimed at improving outcome and minimizing the negative social and occupational effect which often burden these patients.


Subject(s)
Dissociative Disorders/diagnosis , Dissociative Disorders/therapy , Neurology/trends , Psychiatry/trends , Seizures/diagnosis , Seizures/therapy , Diagnosis, Differential , Dissociative Disorders/complications , Humans , Seizures/complications
17.
Osteoarthritis Cartilage ; 16(9): 1032-8, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18602281

ABSTRACT

OBJECTIVE: Evaluation of the internal construct validity of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index adapted for use in patients with femoro-acetabular impingement (FAI) and osteoarthritis (OA) of the hip. METHODS: Distribution of a German version of WOMAC to patients upon first consultation. Patients with FAI [n=100, mean age 31.7 years, standard deviation (SD) 9.7] and OA (n=57, mean age 60.3 years, SD 11.7) and without comorbidities or prior hip surgery were included and compared to age- and gender-matched control population to FAI (n=200, mean age 32.6 years, SD 5.6). WOMAC data of 157 questionnaires were evaluated by Rasch analysis using RUMM2020 software. RESULTS: Summation of total WOMAC shows misfit to the Rasch model as well as multidimensionality. While the pain subset shows adequate fit and is unidimensional, item reduction is required to fit a unidimensional subset of functional items to the Rasch model. Summating the two fitting subsets yields again slight model misfit and multidimensionality requiring further item reduction. Finally, a 12-item version of the total WOMAC shows good model fit and unidimensionality, i.e., internal construct validity, for assessment of patients with FAI and OA without differential item functioning (DIF). A person separation index (PSI)=0.93 indicates a high internal consistency reliability for the 12-item subscale. Scores for FAI are significantly higher than control (P<0.001, effect size 0.71) and lower than OA group (P<0.001, effect size 0.45). Adequate statistical power is shown discriminating the three groups, therefore indicating some evidence also for external construct validity. CONCLUSIONS: The WOMAC as a total construct is multidimensional and summating the subsets into a total score is not valid. The reduced 12-item WOMAC is demonstrated to have internal construct validity for assessing patients with FAI and OA on the same scale and high internal consistency reliability. Discrimination of the groups with adequate statistical power also indicates external construct validity.


Subject(s)
Acetabulum/physiopathology , Femur Head/physiopathology , Osteoarthritis, Hip/physiopathology , Adult , Disability Evaluation , Evaluation Studies as Topic , Female , Humans , Male , Pain/physiopathology , Pain Measurement , Psychometrics , Quality of Life/psychology , Reproducibility of Results , Severity of Illness Index , Surveys and Questionnaires
18.
Orthopade ; 37(7): 659-66, 2008 Jul.
Article in German | MEDLINE | ID: mdl-18597069

ABSTRACT

After disastrous outcomes due to wear-induced osteolysis in the 1980s, hip resurfacing arthroplasty has undergone a renaissance, mainly because of the introduction of metal-on-metal bearings. However, there are still problems associated with this technique, such as femoral neck fractures, neck thinning, and aseptic loosening, and their causes are still being investigated. During the last years, increasing evidence has shown that both the frequently used posterior approach to the hip as well as preparation of the femoral epiphysis can impair blood supply to the femoral head. In the presence of mechanical stresses (impaction, heat development during cement polymerization) during the implantation, the epiphysis might not be able to compensate for this. This paper summarizes the current understanding of the blood supply to the femoral head and proposes a way to preserve the viability after hip resurfacing.


Subject(s)
Arthroplasty, Replacement, Hip/instrumentation , Arthroplasty, Replacement, Hip/methods , Femur Head/blood supply , Hip Prosthesis , Models, Anatomic , Models, Cardiovascular , Blood Flow Velocity , Femur Head/physiology , Femur Head/surgery , Humans , Regional Blood Flow
19.
Orthopade ; 36(8): 746-51, 2007 Aug.
Article in German | MEDLINE | ID: mdl-17541541

ABSTRACT

Chronic irritation of the iliopsoas tendon is a rare cause of persistent pain after total joint replacement of the hip. In the majority of cases, pain results from a mechanical conflict between the iliopsoas tendon and the anterior edge of the acetabular cup after total hip arthroplasty. Pain can be reproduced by active flexion of the hip and by active raising of the straightened leg. In addition, painful leg raising against resistance and passive hyperextension are suggestive of an irritation of the iliopsoas tendon. Symptoms evolve from a mechanical irritation of the iliopsoas tendon and an oversized or retroverted acetabular cup, screws penetrating into the inner aspect of the ilium, or from bone cement protruding beyond the anterior acetabular rim. The diagnosis may be assumed on conventional radiographs and confirmed by CT scans. Fifteen patients with psoas irritation after total hip replacement are reported on. Eleven patients were treated surgically. The acetabular cup was revised and reoriented with more anteversion in six patients, isolated screws penetrating into the tendon were cut and leveled in three patients, and prominent bone cement in conflict with the tendon was resected once. A partial release of the iliopsoas tendon only was performed in another patient. Follow-up examination (range: 11-89 months) revealed that nine patients were free of pain and two patient had mild residual complaints. Psoas irritation in combination with total hip replacement can be prevented by a correct surgical technique, especially with proper selection of the cup size and insertion of the acetabular cup avoiding a rim position exceeding the level of the anterior acetabular rim.


Subject(s)
Arthralgia/etiology , Arthralgia/prevention & control , Arthroplasty, Replacement, Hip/adverse effects , Arthroplasty, Replacement, Hip/methods , Hip Prosthesis/adverse effects , Tendinopathy/etiology , Tendinopathy/prevention & control , Aged , Aged, 80 and over , Arthralgia/diagnosis , Arthroplasty, Replacement, Hip/instrumentation , Device Removal , Female , Humans , Male , Middle Aged , Prosthesis Failure
20.
Hip Int ; 17 Suppl 5: S22-8, 2007.
Article in English | MEDLINE | ID: mdl-19197881

ABSTRACT

Common understanding of residual hip dysplasia of the adult characterizes it as a uniform, anterolateral insufficiency of femoral head coverage; the proximal femur may or may not have increased valgus and antetorsion. This view is reflected by the parameters used for quantification but also by the classic surgical approaches to compensate or correct the deformity. More than two decades of dedication to hip dysplasia and its surgical treatment, but also the application of modern diagnostic tools such as magnetic resonance arthrography have allowed us to portray hip dysplasia more polymorphically showing a number of additional aspects with pathophysiologic, therapeutic and prognostic valence. The rim in acetabular dysplasia shows a variety of pathomorphologies ranging from hypertrophy and tearing of the labrum including fatigue fracture of the rim to degeneration with ganglion formation within the labrum, the capsule or the acetabular bone. Such rim pathology may explain sudden onset of pain but also influences the prognosis of joint preserving surgery. It is a rather new understanding that the acetabular morphology in hip dysplasia is not uniform. Pure lateral and pure anterior deficiency of coverage are small but interesting subgroups. Together with the frequent retroversion of the acetabulum these morphological and spatial aspects require special attention for a precise individual correction of the deformity. Finally, minor morphological abnormalities of the antero-lateral head-neck junction have been found to favor impingement after correction of the acetabulum. Knowledge of this problem has prompted a routine check of internal rotation in flexion during surgery and eventual arthrotomy and osteochondroplasty of the impinging site of the head and neck junction.

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