Shape-Memory Three-Dimensional Evaporators with High Portability for Efficient Solar-Driven Freshwater Production.

Solar-driven water evaporation can alleviate the severe water scarcity situation in a nonpolluting and sustainable manner. Although the design of integrated three-dimensional (3D) solar evaporators has been proven to be effective in achieving ultrahigh evaporation rates and energy efficiency, their scalable application is still hindered by complex manufacturing processes and poor portability. Herein, we report a highly portable shape-memory 3D solar evaporator by depositing MXene on low-cost lignin-cellulosic sponges for freshwater production. When not in use, the 3D evaporator can be compressed into a thin film with up to 89.3% volume reduction, ensuring minimal space occupation and high portability. When needed, due to the shape-memory effect, the 3D structure can be rapidly restored by swelling the compressed film in water, resulting in an efficient 3D solar evaporator. This 3D evaporator exhibits not only a high evaporation rate of 2.48 kg m-2 h-1 under 1 sun illumination but also excellent long-term stability and recyclability. In addition, the 3D evaporator itself can serve as a water reservoir without requiring a continuous water supply during evaporation, showing remarkable application flexibility. This work opens a new perspective for manufacturing highly portable and efficient 3D solar evaporators and may facilitate their progress from the laboratory to commercial applications.

Ti3C2Tx MXene-Based Multifunctional Tactile Sensors for Precisely Detecting and Distinguishing Temperature and Pressure Stimuli.

Although skin-like sensors that can simultaneously detect various physical stimuli are of fair importance in cutting-edge human-machine interaction, robotic, and healthcare applications, they still face challenges in facile, scalable, and cost-effective production using conventional active materials. The emerging two-dimensional transition metal carbide, Ti3C2Tx MXene, integrated with favorable thermoelectric properties, metallic-like conductivity, and a hydrophilic surface, is promising for solving these problems. Herein, skin-like multifunctional sensors are designed to precisely detect and distinguish temperature and pressure stimuli without cross-talk by decorating elastic and porous substrates with MXene sheets. Because the combination of the thermoelectric and conductive MXene with the thermally insulating, elastic, and porous substrate integrates efficient Seebeck and piezoresistive effects, the resultant sensor exhibits not only an ultralow detection limit (0.05 K), high signal-to-noise ratio, and excellent cycling stability for temperature detection but also high sensitivity, fast response time, and outstanding durability for pressure detection. Based on the impressive dual-mode sensing properties and independent temperature and pressure detections, a multimode input terminal and an electronic skin are created, exhibiting great potential in robotic and human-machine interaction applications. This work provides a scalable fabrication of multifunctional tactile sensors for precisely detecting and distinguishing temperature and pressure stimuli.

TMAO promotes dementia progression by mediating the PI3K/Akt/mTOR pathway.

BACKGROUND: Dementia poses a serious threat to the daily and social abilities of patients, and trimethylamine-N-oxide (TMAO) is a metabolite of the gut microbiota involved in regulating the inflammatory response. However, the role of TMAO in dementia needs further investigation. This study aimed to investigate the effects and possible mechanisms of TMAO on dementia, which may provide ideas for the treatment of dementia. MATERIALS AND METHODS: Dementia mice were induced by D-galactose + AlCl3, and the changes in learning memory capacity, histopathology, inflammatory factors, and PI3K/Akt/mTOR in mice treated with TMAO were analyzed to determine the mechanism of TMAO action on dementia. In addition, the effect of TMAO+PI3K inhibitor treatment on mice was also analyzed to further determine the mechanism of TMAO effect on dementia. RESULTS: The results revealed that the dementia group had significantly higher TMAO levels and a significant hippocampal injury and inflammatory response. TMAO treatment promoted hippocampal injury and promoted the level of inflammatory cytokines. Further study of PI3K/Akt/mTOR signaling pathway showed that the expression of p-PI3K, p-Akt, and p-mTOR was significantly increased in the dementia group, and it was more obvious after TMAO treatment. And hippocampal injury, inflammatory response, and increase of p-PI3K, p-Akt, p-mTOR were reversed by TMAO+PI3K inhibitor. CONCLUSIONS: This study determined that TMAO promotes dementia through the PI3K/Akt/mTOR signaling pathway, suggesting that TMAO may be a potential target for dementia.

Self-Powered Resilient Porous Sensors with Thermoelectric Poly(3,4-ethylenedioxythiophene):Poly(styrenesulfonate) and Carbon Nanotubes for Sensitive Temperature and Pressure Dual-Mode Sensing.

Portable and wearable dual-mode sensors that can simultaneously detect multiple stimuli are essential for emerging artificial intelligence applications, and most efforts are devoted to exploring pressure-sensing devices. It is still challenging to integrate temperature and pressure-sensing functions into one sensor without the requirement for complex decoupling processes. Herein, we develop a self-powered and multifunctional dual-mode sensor by dip-coating melamine sponge with both poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and carboxylated single-walled carbon nanotubes (CNTs). By integrating thermoelectric and conductive PEDOT:PSS/CNT components with the hydrophilic and resilient porous sponge, the resultant sensor is efficient in independently detecting temperature and pressure changes. The temperature and pressure stimuli can be independently converted to voltage and electrical resistance signals on the basis of the Seebeck and piezoresistive effects, respectively. The sensor exhibits a high Seebeck coefficient of 35.9 µV K-1 with a minimum temperature detection limit of 0.4 K and a pressure sensitivity of -3.35% kPa-1 with a minimum pressure detection limit of 4 Pa. Interestingly, the sensor can also be self-powered upon illumination. These multi-functionalities make the sensor a promising tool for applications in electronic skin, soft robots, solar energy conversion, and personal health monitoring.

Analysis of risk factors for the development of cognitive dysfunction in patients with cerebral small vessel disease and the construction of a predictive model.

Background: Cognitive dysfunction in cerebral small vessel disease (CSVD) is a common cause of vascular dementia. The purpose of this study was to find independent risk factors for the development of cognitive dysfunction in patients with CSVD and establish a risk prediction model, in order to provide a reference for clinical diagnosis and treatment of such patients. Methods: In this study, clinical data of patients with CSVD admitted to the Department of Neurology in Gansu Provincial Hospital from December 2019 to December 2021 were collected, and 159 patients were finally included after strict screening according to the inclusion and exclusion criteria. There were 43 patients with normal function and 116 patients with cerebral small vessel disease cognitive impairment (CSVDCI). The logistic multivariable regression model was used to screen out the independent risk factors of cognitive dysfunction in patients with CSVD, and the nomogram of cognitive dysfunction in patients with CSVD was constructed based on the results of the logistic multivariable regression analysis. Finally, the accuracy of the prediction model was evaluated by C-index, calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA). Results: The results of multivariable logistic regression analysis showed that hypertension (OR = 2.683, 95% CI 1.119-6.432, P = 0.027), homocysteine (Hcy) (OR = 1.083, 95% CI 1.026-1.143, P = 0.004), total CSVD MRI Score (OR = 1.593, 95% CI 1.025-2.475, P = 0.039) and years of schooling (OR = 0.883, 95% CI 0.798-0.978, P = 0.017) were independent risk factors for the development of cognitive dysfunction in patients with CSVD. The C-index of this prediction model was 0.806 (95% CI 0.735-0.877), and the calibration curve, ROC curve, and DCA curve all showed good predictive power in the nomogram. Conclusions: The nomogram constructed in this study has high accuracy and clinical utility in predicting the occurrence of cognitive dysfunction in patients with CSVD. For patients with CSVD with the above risk factors, active clinical intervention and prevention are required during clinical consultation and disease management to avoid cognitive impairment as much as possible.

Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis.

BACKGROUND: We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). METHODS: We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package. RESULTS: Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10-20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml). CONCLUSION: There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10-20 ng/ml).

Vascular Cognitive Impairment Caused by Cerebral Small Vessel Disease Is Associated with the TLR4 in the Hippocampus.

BACKGROUND: Cerebral small vessel disease (CSVD) can lead to leukodystrophy and cognitive impairment. The inflammatory response mediated by Toll-like receptor 4 (TLR4) is involved in the pathological process of CSVD, but the roles of TLR4 in vascular cognitive impairment (VCI) following CSVD are not clear. OBJECTIVE: To explore the roles and mechanisms of TLR4 in the development of VCI. METHODS: Male spontaneous hypertension rats (SHR) and Wistar Kyoto rats (WKY) were monitored for blood pressure (BP). The spatial learning and memory were assessed every 6 weeks using Morris water maze (MWM). Blood samples from femoral artery were collected and serum was isolated. Cerebral white matter damage was evaluated using a 3.0T magnetic resonance imaging (MRI) every 12 weeks. After 35 weeks, all rats were decapitated, and the expression of TLR4 in the hippocampus was determined using western blot. The number of positive cells of TLR4, active astrocyte and microglia in hippocampus were measured using immunohistochemistry and immunofluorescence. RESULTS: Compared with WKY, the BP of SHR was maintained at a high level. Spatial learning and memory declined. IL-1ß and TNF-α levels were elevated. Cranial coronal scanning with T2-weighted MRI showed high signal intensity in corpus callosum and external capsule of SHR. Furthermore, in SHR, the expression of TLR4, GFAP, and Iba1 in the hippocampus were increased. CONCLUSION: Hypertension can cause small vascular damage and partial white matter degeneration in the brain. SHR showed cognitive impairment with increasing age. High expression of TLR4 and glial cell response in hippocampus is one of the key mechanisms of this disease.

Effect of cerebral small vessel disease on cognitive function and TLR4 expression in hippocampus.

The aim of this study was to explore the differences in cognitive and neurological functions between cerebral small vessel disease (CSVD) rats and normal rats, as well as to study the Toll- like receptor 4 (TLR4) expression in the hippocampus of CSVD rats to understand its role in this brain structure. Forty male, 12-week old, specific pathogen-free (SPF), spontaneously hypertensive rats (SHRs) were used as the observation group, while 20 12-week old, SPF, Wistar male rats were used as the control group. After each measurement, 10 rats in the observation group and 5 in the control group were decapitated to collect samples for determining the expression of TLR4 in the hippocampus. At T1, difference in the latency of rats in the observation group showed no statistically significance (p = 0.836), while at T2, T3 and T4, the observation group showed longer latency than did the control group (p < 0.001). In addition, the latency of SHRs at T1 was the shortest (p < 0.05) compared to the follow-ups (T2-T4) and were followed sequentially by T2, T3, and T4 (p < 0.05). The latency was shorter than those at T1 and T2, and the shortest latency was found at T4 (p < 0.05). CSVD rats exhibited poor cognitive and neurological functions compared to normal rats and high expression of TLR4 in the hippocampus. Based on these results, we suggest that TLR4 affects the cognitive function of CSVD rats, and, thus, may be a valuable target in the treatment of CSVD.

Effectiveness of rituximab in neuromyelitis optica: a meta-analysis.

BACKGROUND: Neuromyelitis optica (NMO) is a severe inflammatory autoimmune disorder of the central nervous system and often results in paralysis or blindness. Rituximab (RTX) is a mouse-human chimeric monoclonal antibody specific for the CD20 antigen on B lymphocytes and used to treat many autoimmune diseases. Disability and relapses were measured using the Expanded Disability Status Scale (EDSS) and annualized relapse rate (ARR) ratio to evaluate the effectiveness of RTX. This review performed a meta-analysis of the efficacy of RTX in NMO. METHODS: We searched through the databases of PubMed, Embase, and Cochrane Library. We compiled 26 studies, in which 18 used ARR ratio, 22 used EDSS score, and 14 used both variables. Differences in the ARR ratio and EDSS score before and after RTX therapy were used as the main efficacy measures. Publication bias was evaluated after the consistency test, and a sensitivity analysis was performed with mean difference (MD) of the efficacy of RTX. RESULTS: A meta-analysis of 26 studies with 577 participants was conducted. Antibodies against aquaporin-4 autoantibody were recorded in 435 of 577 (75.39%) patients with NMO. RTX therapy resulted in a mean (WMD) - 1.56 (95% CI, - 1.82 to - 1.29) reduction in the mean ARR ratio and a mean (WMD) - 1.16 (95% CI, - 1.36 to - 0.96) reduction in the mean EDSS score. A total of 330 of 528 patients (62.9%) reached the relapse-free state. A total of 95 of 577 (16.46%) patients had adverse reactions. CONCLUSIONS: RTX has acceptable tolerance, reduces the relapse frequency, and improves disability in most patients with NMO. Future studies should focus on reducing the health-care costs, improving the functional outcomes, and reducing the adverse effects associated with RTX treatment.

A study on role and mechanism of TLR4/NF-κB pathway in cognitive impairment induced by cerebral small vascular disease.

OBJECTIVE: To investigate the role and potential mechanism of Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway in cognitive impairment induced by cerebral small vascular disease (CSVD), so as to provide a reference for the clinical treatment of CSVD-induced cognitive impairment. METHODS: Mice with TLR4 gene knockout (n = 20) and those with wild-type TLR4 gene (n = 40) aged 8-10 weeks old were divided into blank control group (Control group, n = 20), wild-type + CSVD group (WT + CSVD group, n = 20) and TLR4 gene knockout + CSVD group (TLR4 KO + CSVD group, n = 20). Allogeneic thrombosis (particle diameter: 50-70 mm) was injected to the mouse's external carotid artery to create a model of learning and memory dysfunction. Step-down test and Y-type maze test were utilized to examine the learning and memory abilities of the mice. Reverse transcription-polymerase chain reaction (RT-PCR) and immunoblotting techniques were adopted to measure the levels of apoptosis-related genes [B-cell lymphoma/leukemia-2 (Bcl-2), Bcl-2-associated X protein (Bax), C-caspase-3 and T-caspase-3] in the brain tissues of mice. Terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) method was applied to detect the apoptosis of neuronal cells in the brain tissues. Meanwhile, the levels of oxidative stress markers, including superoxide dismutase (SOD), gp91 and malondialdehyde (MDA), were measured. Finally, the expression level of TLR4/NF-κB pathway was detected. RESULTS: The latency in the step-down test in the WT + CSVD group was remarkably longer than that in the Control group, and the number of errors was evidently larger than that in the Control group (p < 0.05). At the same time, in the WT + CSVD group, the expression levels of pro-apoptotic genes Bax and C-caspase-3 were up-regulated markedly, while the expression level of anti-apoptotic gene Bcl-2 declined notably (p < 0.05). TUNEL results showed that the number of apoptotic cells in the brain tissues in the WT + CSVD group was about 12 times that in the Control group (p < 0.05). Meanwhile, the SOD expression level was lowered, and the MDA expression level was elevated in the brain tissues in the WT + CSVD group. In addition, the TLR4/NF-κB pathway was prominently activated in the mice in the WT + CSVD group (p < 0.05). After TLR4 gene knockout, the cognitive functions of the mice were improved markedly, and the apoptosis of neuronal cells and oxidative stress in the brain tissues were suppressed significantly in the meantime. Moreover, the activation of the TLR4/NF-κB signaling pathway was also inhibited. CONCLUSION: The TLR4/NF-κB pathway is involved in the occurrence and development of CSVD-induced cognitive impairment through regulating oxidative stress and cell apoptosis.

Retinal status analysis method based on feature extraction and quantitative grading in OCT images.

BACKGROUND: Optical coherence tomography (OCT) is widely used in ophthalmology for viewing the morphology of the retina, which is important for disease detection and assessing therapeutic effect. The diagnosis of retinal diseases is based primarily on the subjective analysis of OCT images by trained ophthalmologists. This paper describes an OCT images automatic analysis method for computer-aided disease diagnosis and it is a critical part of the eye fundus diagnosis. METHODS: This study analyzed 300 OCT images acquired by Optovue Avanti RTVue XR (Optovue Corp., Fremont, CA). Firstly, the normal retinal reference model based on retinal boundaries was presented. Subsequently, two kinds of quantitative methods based on geometric features and morphological features were proposed. This paper put forward a retinal abnormal grading decision-making method which was used in actual analysis and evaluation of multiple OCT images. RESULTS: This paper showed detailed analysis process by four retinal OCT images with different abnormal degrees. The final grading results verified that the analysis method can distinguish abnormal severity and lesion regions. This paper presented the simulation of the 150 test images, where the results of analysis of retinal status showed that the sensitivity was 0.94 and specificity was 0.92.The proposed method can speed up diagnostic process and objectively evaluate the retinal status. CONCLUSIONS: This paper aims on studies of retinal status automatic analysis method based on feature extraction and quantitative grading in OCT images. The proposed method can obtain the parameters and the features that are associated with retinal morphology. Quantitative analysis and evaluation of these features are combined with reference model which can realize the target image abnormal judgment and provide a reference for disease diagnosis.

Effect of long-term weightlessness on retina and optic nerve in tail-suspension rats.

AIM: To evaluate the effect of long-term weightlessness on retina and optic nerve in tail-suspension (TS) rats. METHODS: A stimulated weightlessness model was established by suspending rats' tail. After 12wk, the ultrastructure and the number of optic nerve axons were observed by transmission electron microscope. The number of survival retinal ganglion cells (RGCs) was calculated by fluorescent gold retrograde labeling. Retina cells apoptosis was detected by TUNEL staining. The function of optic nerve and retina was evaluated by the visual evoked potential (VEP) and oscillatory potentials (Ops). RESULTS: The optic nerve axons were swollen and sparsely aligned, and the lamellar separation and myelin disintegration occurred after 12wk in TS rats. The density of optic nerve axons was 32.23±3.92 (vs 37.43±4.13, P=0.0145), the RGCs density was 1645±46 cells/mm(2) (vs 1867±54 cells/mm(2) P=0.0000), the incidence rate of retinal cells apoptosis was 5.38%±0.53% (vs 4.75%±0.54%, P=0.0238), the amplitude of VEP-P100 was 15.43±2.14 µV (vs 17.67±2.17 µV, P=0.0424), the latency of VEP-P100 was 69.05±5.34ms (vs 62.43±4.87ms P=0.0143) and the sum amplitude of Ops was 81.05±8.34 µV (vs 91.67±10.21 µV, P=0.0280) in TS group and the control group, respectively. CONCLUSION: Long-term weightlessness can induce the ultrastructural changes and functional depress of the optic nerve, as well as retinal cell damages in TS rats.

Influence of N(2)O(4) on multifocal electroretinogram in winstar mice.

AIM: To record multifocal electroretinogram from different dosage of N(2)O(4) injected mice. In order to provide a foundation for further study. METHODS: Normal winstar mice which were injected by different dosage of N(2)O(4) were studied for recording multifocal electroretinogram in the same time in the evening after N(2)O(4) injection. RESULTS: The latency and amplitude density of "b" wave of each ring of multifocal electroretinogram was studied. The latency of "b" wave of each ring of multifocal electroretinogram of each group varies to each other. But the difference of the amplitude of "b" wave of multifocal electroretinogram of each ring between each group had no significance. CONCLUSION: Recording multifocal electroretinogram of N(2)O(4) injected mice will give more support for further study in related science and clinic research.