Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Phys Chem B ; 128(16): 3910-3918, 2024 Apr 25.
Article in English | MEDLINE | ID: mdl-38607690

ABSTRACT

Viscosity, at the subcellular level, plays a crucial role as a physicochemical factor affecting microenvironment homeostasis. Abnormal changes in mitochondrial viscosity often lead to various diseases in the organism. Based on the twisted intramolecular charge transfer mechanism, four hemicyanine dye fluorescent probes (HT-SA, HT-SA-S, HT-Bzh, and HT-NA) were designed and synthesized for viscosity response. The single bond between the nitrogen-containing heterocycle and the carbon-carbon double in the structure of the probe bond served as the viscosity response site. Finally, the probe HT-Bzh was screened as the optimal mitochondrial viscosity probe according to its responsiveness, targeting, and interference resistance. The fluorescence intensity of the probe HT-Bzh increased 22-fold when the viscosity was increased from 13.75 to 811.2 cP. In summary, all four viscosity probes we have developed can be used in different applications depending on the external environment, providing a valuable reference for the design of potential tools to address viscosity monitoring in biological systems.


Subject(s)
Carbocyanines , Fluorescent Dyes , Mitochondria , Fluorescent Dyes/chemistry , Fluorescent Dyes/chemical synthesis , Viscosity , Carbocyanines/chemistry , Mitochondria/metabolism , Mitochondria/chemistry , Humans , HeLa Cells , Molecular Structure , Optical Imaging
SELECTION OF CITATIONS
SEARCH DETAIL
...