Psycho-physiological responses to perceptually-regulated interval runs in hypoxia and normoxia.

We investigated whether perceptually-regulated high-intensity intervals in hypoxia are associated with slower running velocities versus normoxia, when physiological responses and exercise-related sensations remain the same. Nineteen trained runners (33.4 ±â€¯9.1 years) completed a high-intensity interval running protocol (4 × 4-min intervals at a clamped perceived rating exertion of 16 on the 6-20 Borg scale, 3-min passive recoveries) in either hypoxic (HYP; FiO2 15.0%) or normoxic (NOR; FiO2 20.9%) conditions. Participants adjusted to a progressively slower running velocity from interval 1-4 (-7.0%), and more so in HYP vs. NOR for intervals 2, 3 and 4 (-4.6%, -6.4% and - 7.9%, respectively; p < .01). Heart rate increased from interval 1-4 (+4.8%; p < .01), independent of condition. Arterial oxygen saturation was lower in HYP vs. NOR (86.0% vs. 94.8%; p < .01). Oxyhemoglobin (-23.7%) and total hemoglobin (-77.0%) decreased, whilst deoxyhemoglobin increased (+44.9%) from interval 1-4 (p < .01), independent of condition. Perceived recovery (-41.6%) and motivation (-21.8%) were progressively lower from interval 1-4, and more so in HYP vs. NOR for intervals 2, 3 and 4 (recovery: -8.8%, -24.2% and - 29.3%; motivation: -5.3%, -20.3% and - 22.4%, respectively; p < .01). Perceived breathlessness (+18.6%), limb discomfort (+44.0%) and pleasure (-32.2%) changed from interval 1-4, with significant differences (+21.8%, +11.3% and - 31.3%, respectively) between HYP and NOR (p < .01). Slower interval running velocities in hypoxia achieve similar heart rate and muscle oxygenation responses to those observed in normoxia when perceptually-regulated, yet at the expense of less favourable exercise-related sensations.

Normobaric hypoxic conditioning to maximize weight loss and ameliorate cardio-metabolic health in obese populations: a systematic review.

Normobaric hypoxic conditioning (HC) is defined as exposure to systemic and/or local hypoxia at rest (passive) or combined with exercise training (active). HC has been previously used by healthy and athletic populations to enhance their physical capacity and improve performance in the lead up to competition. Recently, HC has also been applied acutely (single exposure) and chronically (repeated exposure over several weeks) to overweight and obese populations with the intention of managing and potentially increasing cardio-metabolic health and weight loss. At present, it is unclear what the cardio-metabolic health and weight loss responses of obese populations are in response to passive and active HC. Exploration of potential benefits of exposure to both passive and active HC may provide pivotal findings for improving health and well being in these individuals. A systematic literature search for articles published between 2000 and 2017 was carried out. Studies investigating the effects of normobaric HC as a novel therapeutic approach to elicit improvements in the cardio-metabolic health and weight loss of obese populations were included. Studies investigated passive (n = 7; 5 animals, 2 humans), active (n = 4; all humans) and a combination of passive and active (n = 4; 3 animals, 1 human) HC to an inspired oxygen fraction ([Formula: see text]) between 4.8 and 15.0%, ranging between a single session and daily sessions per week, lasting from 5 days up to 8 mo. Passive HC led to reduced insulin concentrations (-37 to -22%) in obese animals and increased energy expenditure (+12 to +16%) in obese humans, whereas active HC lead to reductions in body weight (-4 to -2%) in obese animals and humans, and blood pressure (-8 to -3%) in obese humans compared with a matched workload in normoxic conditions. Inconclusive findings, however, exist in determining the impact of acute and chronic HC on markers such as triglycerides, cholesterol levels, and fitness capacity. Importantly, most of the studies that included animal models involved exposure to severe levels of hypoxia ([Formula: see text] = 5.0%; simulated altitude >10,000 m) that are not suitable for human populations. Overall, normobaric HC demonstrated observable positive findings in relation to insulin and energy expenditure (passive), and body weight and blood pressure (active), which may improve the cardio-metabolic health and body weight management of obese populations. However, further evidence on responses of circulating biomarkers to both passive and active HC in humans is warranted.

Cognitive function in hot environments: a question of methodology.

The physiological responses of thermal stress and its consequences on health have been well documented. However, the effect on cognitive function remains equivocal despite a substantial number of studies conducted in the area. Methodological discrepancies across different studies have made it difficult to conclude whether or not heat exposure per se has an adverse effect upon cognitive function and under what specific environmental and physiological conditions these alterations appear. This article gives an overview of the different confounding factors that have made it difficult to make conclusive interpretations. In addition, the current state of knowledge is presented and discussed with reference to the Global Workspace theory. Although previously presented conclusions are promising, much remains to be completed before understanding the mechanisms that could explain the relationship between heat exposure and cognitive function. Finally, recommendations are presented for further research in this area.

Hyperthermia impairs short-term memory and peripheral motor drive transmission.

The aims of this study were to determine (i) the effect of passive hyperthermia on motor drive and cognitive function, and (ii) whether head cooling can limit the hyperthermia-induced alterations. Sixteen subjects were randomly exposed for 2 h to three different conditions: control (Con, 20 degrees C), hot (Hot, 50 degrees C) and hot head cool (HHC--where cold packs were applied to the head under Hot conditions). Three cognitive tests measuring attention and two measuring memory were performed. Neuromuscular testing included electrically evoked muscle action potentials (M-waves) and reflex waves (H-reflex) at rest and during brief (4-5 s) and sustained (120 s) maximal voluntary contractions (MVC) of the plantar flexors. All the tests were performed in the environmental room. During brief MVC, torque was significantly lower in both Hot and HHC as compared to Con (P < 0.05). The decrease in muscle activation was significant in Hot (P < 0.05) but not in HBC (P = 0.07). This was accompanied by peripheral failures in the transmission of the neural drive at both spinal (significant decrements in H-reflexes and V-waves, P < 0.05) and neuromuscular junction (significant decrements in M-waves, P < 0.05) levels. During sustained MVC, muscle activation was further depressed (P < 0.05) without any concomitant failures in M-waves, suggesting neural activation adjustments occurring probably at the supraspinal level. Cerebral perturbations were confirmed by significant decrements in both memory tests in Hot as compared with Con (P < 0.05) but not in simple tests (attention tests) that were not affected by hyperthermia. The decrement in memory capacity suggested the existence of frontal lobe activity impairments. Thus, HHC preserved memory capacity but not the visual memory.