ABSTRACT
Protease activities in serum and urine of 116 children with glomerulonephritis and 16 healthy children were tested using chromogenic peptide substrates Z-Dala_Leu-Arg-pNA and Glp-Ala-ALa-Leu-pNa. We found the dependence between activity of serine proteinases and clinical, morphological forms of primary glomerulonephritis and hypertension.
Subject(s)
Chymotrypsin/metabolism , Glomerulonephritis/enzymology , Trypsin/metabolism , Adolescent , Child , Child, Preschool , Chymotrypsin/blood , Chymotrypsin/urine , Glomerulonephritis/blood , Glomerulonephritis/complications , Humans , Hypertension/complications , Hypertension/enzymology , Substrate Specificity , Trypsin/blood , Trypsin/urineABSTRACT
The investigation of the effectiveness of a diet supplemented with n-3 PUFA in children with glomerulonephritis was done. Patients receiving "Polyen" achieved better clinical remission, more rapid decrease of hypercholesterolemia, and hypercoagulation than the patients from the control group. We can recommend "Polyen" usage in the treatment of glomerulonephritis in children.
Subject(s)
Child Nutritional Physiological Phenomena , Fatty Acids, Omega-3/therapeutic use , Fish Oils , Glomerulonephritis/diet therapy , Capsules , Child , Child, Preschool , Cholesterol/blood , Dietary Supplements , Energy Intake , Erythrocyte Membrane/chemistry , Fatty Acids, Nonesterified/blood , Fatty Acids, Omega-3/administration & dosage , Fatty Acids, Unsaturated/blood , Glomerulonephritis/blood , Glomerulonephritis/drug therapy , Humans , Membrane Lipids/blood , PediatricsABSTRACT
The effects of supplementation of basic diets with 'Polyen' in daily doses of 2.5-4.0 g during 30-40 days together with antioxidants were studied in patients with kidney diseases (diet No7, n = 14), different allergies (hypoallergenic diet, n = 37) and in control children (n = 12). It was shown positive dynamics in fatty acid contents in plasma and red blood cell membranes, in humoral and cell immunity indicators and in improving of clinical symptoms of diseases. 'Polyen' is recommended for wide use in pediatric practice.
