Characterization, mathematical modeling of moisture sorption isotherms and bioactive compounds of Andean root flours.

Andean roots can be used as an alternative to gluten-free food. The objective of this study was to enhance the technological and nutritional properties of Andean root flours to promote their industrial applicability. The water content and activity of the flour were lower than those required to prevent mold growth. The bulk density of the flour was comparable to that of wheat flour. The flour of Ipomoea batatas (L.) Lam. exhibited the lowest water absorption capacity of the tested samples. However, both this flour and Tropaeolum tuberosum Ruiz & Pavón showed a higher fat absorption capacity. The samples exhibited type-II isotherms, indicating that the flours were highly hygroscopic. The Guggenheim, Anderson, and de Boer GAB model showed a higher coefficient of determination in mathematical modeling. The chroma of T. tuberosum Ruiz & Pavón flour was higher than the other samples, which was related to total carotenoids and lycopene. Furthermore, I. batatas (L.) Lam. exhibited the highest phenol value.

Thermoluminescent glow curve of Gd1-xRExAlO3 (RE=Dy or Pr) beta irradiated phosphors.

Phosphors composed of Gd1-xRExAlO3 (0≤x ≤ 5 RE = Dy or Pr) stoichiometries were synthesized using the reverse coprecipitation pathway. The thermoluminescent responses of all phosphors were studied under beta radiation exposure. Doping the gadolinium aluminate host improved the thermoluminescent response of the phosphors, with the phosphors composed of Gd0.99Dy0.01AlO3 and Gd0.95Pr0.05AlO3 being the most sensitive. The Dy3+ ions produced a higher improvement of the thermoluminescent signal than the Pr3+ ions. Additionally, a proportional relationship between the similarity of the atomic numbers of the dopant and replaced ions and the sensitivity to thermoluminescence was confirmed. Besides, a slight shift of the thermoluminescent peaks toward lower temperatures was detected for doped phosphors. In the repeatability tests applied to the phosphor composed of Gd0.99Dy0.01AlO3, an anomalous increase in sensitization was observed. The observed sensitization was associated with the formation of electron trap clusters resulting from the continuous exposure to beta radiation. Furthermore, another sensitization phenomenon was detected in the phosphor with Gd0.95Pr0.05AlO3 stoichiometry when it was heated at low temperatures. The aforementioned striking behavior was related to quasi-continuous distributions of electron traps and the tunneling effect. In regard to linearity, the phosphor composed of Gd0.99Dy0.01AlO3 exhibited a linear response with the dose across the entire range of beta doses. However, the response of the Gd0.95Pr0.05AlO3 phosphor lost linearity beyond 26.4 Gy of beta dose. The results obtained through the use of the Tmax-Tstop method and deconvolutions suggested an enhancement in the efficiency of the thermoluminescent mechanisms due to the incorporation of activators.

Thyroid Fine Needle Aspiration, the Bethesda System, and the BRAFV600E Mutation in Papillary Thyroid Carcinoma: Association and Prediction for Biopsy.

INTRODUCTION: BRAFV600E mutations have been associated with papillary thyroid carcinoma (PTC) histological types including tall-cell and classical, peritumoral infiltration, and nuclear signs, whereas cytological features such as plump cells and sickle nuclei have also been associated with favorable thyroid fine needle aspiration (FNA) results for this tumor. BRAF and RAS are considered early driver mutations that contribute to the development of BRAF-like PTCs and RAS-like PTCs. Our aim was to assess the possible association between all Bethesda System cytological features and thyroid FNAs for PTC and their potential predictive value for future BRAFV600E-related biopsies. METHODS: Our study analyzed 63 cases of PTCs operated on at our hospital over a 5-year period between 2005 and 2017 that had previously undergone FNA and had been classified by the Bethesda System. BRAFV600E was identified by pyrosequencing paraffin-embedded tissues and comparing the cytological signs with the Bethesda System. In addition, a statistical and predictive study of the diagnostic factors "non-follicular," "non-round nuclei," and "non-clear chromatin" was performed to discriminate BRAF-like signs from other hypothetical RAS-like follicular signs. RESULTS: BRAFV600E was detected in 43/63 cases (68.2%). Histological types were significant (p < 0.001), with the classical variant being the most prevalent 31/63 (49.2%) and independent by multivariate analysis odds ratio of 10.58 [2.67; 41.97]. Follicular cytological signs are negatively associated with BRAFV600E: follicular structure (p < 0.001), round nuclei (p = 0.015), and clear chromatin (p = 0.049), while the diagnostic factors: "non-follicular" (positive predictive value [PPV] 82.9, sensitivity 79.1, negative predictive value [NPV] 59.1, specificity 65.0), "non-round nuclei" (PPV 76.6, sensitivity 83.7, NPV 56.3, specificity 45.0), and "non-clear chromatin" (PPV 75.6, sensitivity 79.1, NPV 50.0, specificity 45.0) have predictive value for the mutation. There was no individual significance for the remaining cytological features. CONCLUSIONS: Our study found no association between cytomorphological signs of thyroid FNA and BRAFV600E mutation. Considering the Bethesda System, there is an association (p = 0.045) with numerous cases of mutated PTC in categories V and VI. Our results indicate, however, that the presence of signs referred to as "non-follicular," "non-round nuclei," and "non-clear chromatin" in biopsy of papillary thyroid carcinoma is predictive of BRAF type mutation, whereas follicular signs indicate a RAS type PTC, according to published literature. These results need to be confirmed or modified by further research.

Smart Mobility and Smart Climate: An Illustrative Case in Seville, Spain.

In recent years, smart city projects and initiatives have surged around the globe. Yet, a wide range of factors determine the success or failure of such initiatives and there is still a long road ahead in terms of effective governance and innovation management. In such a context, this study explores the specific case of PCT Cartuja (science and technology park in Seville, Spain)-analyzing several smart-mobility and smart-climate solutions from a Triple Helix Model standpoint. The authors tap into multiple information sources to describe the case and key implications of smart initiatives for both theory and management are discussed. This paper shows the current progress as well as the remaining challenges to illustrate how public-private partnerships and conflict can be effectively managed.

Thermoluminescence analysis of beta particle irradiated Gd1-xEuxAlO3 phosphors.

The suitable choice of an activator and host combination is essential for synthesizing very sensitive thermoluminescence phosphors. In addition, conspicuous synthesis variables must be optimized to achieve the maximal response. The research presented herein shows that the most recommendable conditions to improve the thermoluminescence response of beta irradiated Gd1-xEuxAlO3 phosphors were: x = 0.02 for europium stoichiometry and 1500 °C for the calcination temperature. The glow curve recorded for the most sensitive phosphor was partially erased by photo-bleaching, and thus, should yield optically stimulated luminescence.

Anti-Zic4 paraneoplastic cerebellar degeneration in a patient with EGFR-mutated NSCLC: a case report.

Paraneoplastic cerebellar degeneration (PCD) is one of the most prevalent neurological paraneoplastic syndromes, typically associated with small cell lung cancer (SCLC). PCD is thought to be caused by proteins expressed by tumor cells which trigger an antibody-mediated immune response. Despite PCD being commonly associated with anti-Yo, anti-Hu and anti-Tr/DNER antibodies, PCD is the most prevalent paraneoplastic syndrome in patients harboring anti-Zic4 antibodies. We report what, to our knowledge, is the first known case of anti-Zic4 mediated PCD in a patient with EGFR-mutated metastatic non-small cell lung cancer (NSCLC). Our patient was in complete response (CR) to targeted therapy and presented to the emergency room with drowsiness, unsteady gait and memory lapses. The diagnostic work-up revealed a diffuse cerebellar atrophy in the MRI, ruling out brain metastasis and leptomeningeal carcinomatosis. A body-CT scan showed no signs of recurrent disease. The cerebrospinal fluid (CSF) was within normal parameters. An onconeural antibody panel was conducted in a peripheral blood sample, detecting high levels of anti-Zic4 antibody by indirect immunofluorescence (IFI), results later confirmed by immunoblot testing. With the suspected diagnosis of an anti-Zic4 PCD, the case was discussed with the neurology department and treatment with high dose methylprednisolone was initiated. Considering the lack of substantial clinical benefit, the patient was then treated with intravenous immunoglobulins (IVIG) for 5 days, showing modest improvement. At this time, the patient presented minor disease relapse in the form of a sub-centimetric pulmonary nodule. Despite one cycle of chemotherapy, the patient's neurological condition deteriorated leading to fatal pneumonia secondary to progressive dysphagia. There is scarce evidence of paraneoplastic syndromes in EGFR-mutated NSCLC. Further research is warranted to stablish a possible association between anti-Zic4 and the EGFR molecular pathway.

Blood Biomarkers of Response to Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of non-small cell lung cancer (NSCLC), either used in monotherapy or in combination with chemotherapy. While some patients achieve durable responses, some will not get benefit from this treatment. Early identification of non- responder patients could avoid unnecessary treatment, potentially serious immune-related adverse events and reduce treatment costs. PD-L1 expression using immunohistochemistry is the only approved biomarker for the selection of patients that can benefit from immunotherapy. However, application of PD-L1 as a biomarker of treatment efficacy shows many deficiencies probably due to the complexity of the tumor microenvironment and the technical limitations of the samples. Thus, there is an urgent need to find other biomarkers, ideally blood biomarkers to help us to identify different subgroups of patients in a minimal invasive way. In this review, we summarize the emerging blood-based markers that could help to predict the response to ICIs in NSCLC.

Public healthcare costs associated with long-term exposure to mixtures of persistent organic pollutants in two areas of Southern Spain: A longitudinal analysis.

BACKGROUND: Polychlorinated biphenyls and organochlorine pesticides are persistent organic pollutants (POPs) that had been banned or restricted in many countries, including Spain. However, their ubiquity still poses environmental and human health threats. OBJECTIVE: To longitudinally explore public healthcare costs associated with long-term exposure to a mixture of 8 POPs in a cohort of residents of two areas of Granada Province, Southern Spain. METHODS: Longitudinal study in a subsample (n = 385) of GraMo adult cohort. Exposure assessment was performed by analyzing adipose tissue POP concentrations at recruitment. Average primary care (APC) and average hospital care (AHC) expenditures of each participant over 14 years were estimated using the data from their medical records. Data analyses were performed by robust MM regression, weighted quantile sum regression (WQS) and G-computation analysis. RESULTS: In the adjusted robust MM models for APC, most POPs showed positive beta coefficients, being Hexachlorobenzene (HCB) significantly associated (ß: 1.87; 95% Confidence interval (95%CI): 0.17, 3.57). The magnitude of this association increased (ß: 3.72; 95%CI: 0.80, 6.64) when the analyses were restricted to semi-rural residents, where ß-HCH was also marginally-significantly associated to APC (ß: 3.40; 95%CI: -0.10, 6.90). WQS revealed a positive but non-significant mixture association with APC (ß: 0.14; 95%CI: -0.06, 0.34), mainly accounted for by ß-HCH (54%) and HCB (43%), that was borderline-significant in the semi-rural residents (ß: 0.23; 95%CI: -0.01, 0.48). No significant results were observed in G-Computation analyses. CONCLUSION: Long-term exposure to POP mixtures might represent a modifiable factor increasing healthcare costs, thus affecting the efficiency of the healthcare systems. However, and owing the complexity of the potential causal pathways and the limitations of the present study, further research is warranted to fully elucidate ascertain whether interventions to reduce human exposure should be considered in healthcare policies.

Marcelino Weiss y Gramatges, su legado en la formación de los estomatólogos de Sancti Spíritus / Marcelino Weiss y Gramatges, his legacy in the training of stomatologists in Sancti Spíritus

RESUMEN Fundamento: Marcelino Weiss fue un reconocido estomatólogo que luchó para que el dentista fuera un médico especializado. Objetivo: Describir la vida personal y profesional de Marcelino Weiss y Gramatges y su legado a la estomatología de Sancti Spíritus. Metodología: Se realizó un estudio relacionado con la historia en ciencias de la salud, sobre la vida de Marcelino Weiss y Gramatges desde su nacimiento en Sancti Spíritus 1877 hasta su fallecimiento en La Habana en 1927, para lo cual se confeccionó una estrategia de búsqueda de la información, se consultaron bases de datos disponibles en el portal de Infomed. Se emplearon métodos del nivel teórico y métodos empíricos. Conclusiones: La vida y obra del Dr. Marcelino Weiss y Gramatges constituye un paradigma a seguir para las actuales y futuras generaciones de profesionales de la estomatología espirituana. Por sus valores, destacada labor patriótica, notable trayectoria asistencial, docente e investigativa, logró el reconocimiento y la admiración de todos.

ABSTRACT Background: Marcelino Weiss was a renowned stomatologist who fought for the dentist to be a specialized physician. Objective: To describe the personal and professional life of Marcelino Weiss y Gramatges and his legacy to stomatology in Sancti Spíritus. Methodology: A study related to the history of health sciences was conducted on Marcelino´s Weiss y Gramatges life from his birth in Sancti Spíritus in 1877 to his death in Havana in 1927, for that, an information search strategy was prepared, some databases available on the Infomed site were consulted. Theoretical and empirical methods were used. Conclusions: The life and work of Dr. Marcelino Weiss y Gramatges is a paradigm to be followed by current and future generations from Sancti Spíritus dental professionals. For his values, outstanding patriotic work, and remarkable care, teaching and research career, he achieved total recognition and admiration.

FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) unmasked by withdrawal of immunosuppression for Crohn's disease?

A 31-year-old pregnant woman presented with headache, fever and left-sided focal motor seizures, which progressed to bilateral tonic-clonic seizures. Her medical history included Crohn's disease treated with azathioprine and adalimumab, which were discontinued when she became pregnant. Her cerebro-spinal fluid was entirely normal and viral PCR negative. Extensive testing for infectious, autoimmune or malignant causes of encephalitis were non-revealing. MRI head showed unilateral cortical FLAIR-hyperintensity which on interval scans was seen bilaterally. Anti-myelin-oligodendrocyte glycoprotein (MOG)-IgG was positive leading to a diagnosis of cortical FLAIR-hyperintense lesions in Anti-MOG-associated Encephalitis with seizures (FLAMES).

Endocrine and Growth Abnormalities in 4H Leukodystrophy Caused by Variants in POLR3A, POLR3B, and POLR1C.

CONTEXT: 4H or POLR3-related leukodystrophy is an autosomal recessive disorder typically characterized by hypomyelination, hypodontia, and hypogonadotropic hypogonadism, caused by biallelic pathogenic variants in POLR3A, POLR3B, POLR1C, and POLR3K. The endocrine and growth abnormalities associated with this disorder have not been thoroughly investigated to date. OBJECTIVE: To systematically characterize endocrine abnormalities of patients with 4H leukodystrophy. DESIGN: An international cross-sectional study was performed on 150 patients with genetically confirmed 4H leukodystrophy between 2015 and 2016. Endocrine and growth abnormalities were evaluated, and neurological and other non-neurological features were reviewed. Potential genotype/phenotype associations were also investigated. SETTING: This was a multicenter retrospective study using information collected from 3 predominant centers. PATIENTS: A total of 150 patients with 4H leukodystrophy and pathogenic variants in POLR3A, POLR3B, or POLR1C were included. MAIN OUTCOME MEASURES: Variables used to evaluate endocrine and growth abnormalities included pubertal history, hormone levels (estradiol, testosterone, stimulated LH and FSH, stimulated GH, IGF-I, prolactin, ACTH, cortisol, TSH, and T4), and height and head circumference charts. RESULTS: The most common endocrine abnormalities were delayed puberty (57/74; 77% overall, 64% in males, 89% in females) and short stature (57/93; 61%), when evaluated according to physician assessment. Abnormal thyroid function was reported in 22% (13/59) of patients. CONCLUSIONS: Our results confirm pubertal abnormalities and short stature are the most common endocrine features seen in 4H leukodystrophy. However, we noted that endocrine abnormalities are typically underinvestigated in this patient population. A prospective study is required to formulate evidence-based recommendations for management of the endocrine manifestations of this disorder.

Targeting KRAS in Non-Small Cell Lung Cancer.

Kirsten Rat Sarcoma viral oncogene homolog (KRAS) is the most frequently altered oncogene in Non-Small Cell Lung Cancer (NSCLC). KRAS mutant tumors constitute a heterogeneous group of diseases, different from other oncogene-derived tumors in terms of biology and response to treatment, which hinders the development of effective drugs against KRAS. Therefore, for decades, despite enormous efforts invested in the development of drugs aimed at inhibiting KRAS or its signaling pathways, KRAS was considered to be undruggable. Recently, the discovery of a new pocket under the effector binding switch II region of KRAS G12C has allowed the development of direct KRAS inhibitors such as sotorasib, the first FDA-approved drug targeting KRAS G12C, or adagrasib, initiating a new exciting era. However, treatment with targeted KRAS G12C inhibitors also leads to resistance, and understanding the possible mechanisms of resistance and which drugs could be useful to overcome it is key. Among others, KRAS G12C (ON) tricomplex inhibitors and different combination therapy strategies are being analyzed in clinical trials. Another area of interest is the potential role of co-mutations in treatment selection, particularly immunotherapy. The best first-line strategy remains to be determined and, due to the heterogeneity of KRAS, is likely to be based on combination therapies.

Impact of 68Ga-PSMA PET/CT in the treatment of prostate cancer: Initial experience in Spain.

AIM: To evaluate whether positron-emission tomography/computed tomography with 68Ga-PSMA (68Ga-PSMA PET/CT) influences the therapeutic management of patients with primary or recurrent prostate cancer (PCa). BACKGROUND: Although 68Ga-PSMA PET/CT is one of the best options for staging or restaging patients with PCa, its availability is still very limited in Spain. The present study reports the results of the first group of patients in Spain who underwent 68Ga-PSMA PET/CT imaging. MATERIALS AND METHODS: All patients (n = 27) with a histological diagnosis of PCa who underwent 68Ga-PSMA PET/CT prior to the definitive treatment decision at the only centre with this technology in Spain during 2017-2018 were included. Two nuclear medicine physicians and a radiologist reviewed the imaging studies. The clinical impact was assessed from a theoretical perspective, based on the treatment that would have been applied if no data from the 68Ga-PSMA PET/CT were available. RESULTS: Most patients (n = 26; 96%) had persistent disease or biochemical recurrence after radical prostatectomy, radiotherapy, or combined treatment. One patient underwent 68Ga-PSMA PET/CT imaging to stage high-risk PCa. Overall, 68Ga-PSMA PET/CT was positive in 19 patients (70.4%). In 68.75% of these patients, none of the other imaging tests-MRI, CT, or bone scans-performed prior to the 68Ga-PSMA PET/CT were able to detect the presence of cancerous lesions. Overall, the findings of the 68Ga-PSMA PET/CT led to a modification of the therapeutic approach in 62.96% of the patients in the study. CONCLUSIONS: 68Ga-PSMA PET/CT alters the therapeutic approach in a substantial proportion of patients with PCa.

Praxis induction and its relationship with cognition in genetic generalized epilepsy.

INTRODUCTION: Praxis induction (PI) is a reflex trait defined as the precipitation of epileptic discharges (ED) or seizures by cognition-guided tasks that often involve visuomotor coordination and decision-making. This is a characteristic of genetic generalized epilepsy (GGE), and especially of juvenile myoclonic epilepsy (JME). Additionally, several studies have described dysexecutive traits in these patients. Our objective was to analyze PI in the different syndromes of GGE and explore the relationship between PI and cognitive performance. METHODS: Sixty-one adult patients with GGE underwent video-electroencephalograph (EEG) during which a neuropsychological activation protocol (NPAP) was performed: reading, writing, calculations, crosswords, and tangram. Praxis induction was defined by the presence of ED during the NPAP with a persistence of at least twice seen on the basal EEG. All patients also underwent a comprehensive cognitive evaluation. RESULTS: We observed PI in 22 out of 61 patients (36%). Grouped by syndrome, PI was more frequent in adult patients with persistent childhood or juvenile absence epilepsy (JAE, 60%), followed by JME (42.1%) and in a lesser grade in patients with only tonic-clonic generalized seizures (9%). Patients classified as having PI did not obtain worse results in the cognitive evaluation. The presence of ED during the performance of a test was associated with a trend to lower results in that specific test. SIGNIFICANCE: Our study showed a relevant presence of PI in patients whose absence epilepsy persists into adulthood, and not only in JME, the syndrome classically associated with PI. According to our results, PI as a reflex trait does not imply necessarily a poorer cognitive phenotype, but the induction of frequent ED during the tasks could be associated with transient cognitive impairment.

Development of Thyroid Carcinoma During Treatment With Pembrolizumab in a Lung Cancer Patient.

Pembrolizumab, a programmed death 1 inhibitor, has been shown to have clinically significant efficacy in different types of cancer, providing long-term survival benefit for patients with lung cancer. Herein, we report the development of a primary thyroid cancer in a lung cancer patient that was being treated with pembrolizumab. Primary thyroid malignancy (and not only metastatic disease or immunotherapy-induced thyroiditis) should be considered in patients with lung cancer being treated with immune checkpoint inhibitors who develop new incidental thyroid lesions on imaging studies.

Tumor maligno de la vaina del nervio periférico primario de mama / Malignant peripheral nerve sheath tumor of the breast

Los tumores malignos de la vaina del nervio periférico representan del 5 al 10% del total de tumores malignos de tejidos blandos y frecuentemente se asocian con la neurofibromatosis tipoI. Su presentación en la glándula mamaria es poco frecuente, y el diagnóstico es muy difícil por su rareza y por la ausencia de características clínicas y/o radiológicas específicas, siendo preciso una adecuada interpretación del estudio inmunohistoquímico y su correlación con los hallazgos morfológicos. Presentamos un caso clínico y su revisión bibliográfica

Malignant peripheral nerve sheath tumours represent 5-10% of all malignant soft tissue tumours and are frequently associated with neurofibromatosis typeI. Their presentation in the mammary gland is rare. Because of this rarity, as well as the absence of specific clinical and/or radiological features, their diagnosis very difficult. It is therefore essential to correctly interpret immunohistochemical analysis and its correlation with morphological findings. We present a clinical case and literature review

The cognitive phenotype of idiopathic generalized epilepsy.

OBJECTIVE: Dysexecutive traits have been described in idiopathic generalized epilepsy (IGE), but studies mainly focused on juvenile myoclonic epilepsy (JME). To better understand the neuropsychology of IGE, more research is needed on syndromes other than JME, controlling potential confounding factors as the cognitive effects of valproate and epileptic discharges (ED). We describe the neuropsychological profile of a group of patients with different syndromes of IGE including simultaneous video electroencephalography (EEG). METHODS: We performed a comprehensive cognitive and neuropsychiatric evaluation with video-EEG on 61 adults with IGE (JME 19; IGE with generalized tonic-clonic seizures [GTCS] alone [IGE-GTCS] 22; childhood absence epilepsy [CAE] or juvenile absences epilepsy [JAE] persisting in adulthood 20). We compared results between patients (globally and by syndrome) and a control group of 21 individuals (similar age, educational level); p-values were adjusted for multiple testing according to a 0.05 false discovery rate. RESULTS: Patients obtained significantly lower results than controls on visuospatial working memory, processing speed, cognitive flexibility and strategy, abstract visuospatial reasoning, arithmetic, and acquired knowledge. While CAE/JAE showed the lowest scores on cognitive assessment and highest anxiety index, IGE-GTCS showed the most favorable scores. Most tests were not influenced by valproate intake, and the dose did not correlate with cognitive performance in the test that yielded differences between patients and controls. Epileptic discharges during assessment were not frequent (10 patients, 1-4 tests). SIGNIFICANCE: Our findings suggest that patients with IGE have significantly lower abilities in various executive functions and acquired knowledge, compared to population of same age and education. The low frequency of ED on simultaneous video-EEG and absence of correlation of scores with valproate dose reinforce that the obtained results are due to a cognitive phenotype in IGE. This phenotype may be influenced by syndrome, and patients with CAE/JAE persisting in the adult may have a wider neuropsychiatric impairment.

Evaluación de la calidad de la atención estomatológica de dos servicios de Estomatología General Integral. Sancti Spíritus. 2018 / Evaluation of the quality of dental care of two General Comprehensive Stomatology services. Sancti Spíritus. 2018

RESUMEN Fundamento: La calidad de la atención estomatológica está caracterizada en el proceso y factores que intervienen en la prestación de los servicios, dirigidos a alcanzar buenos resultados en lo que a salud bucal se refiere. Objetivo: Evaluar la calidad de la atención estomatológica de dos servicios de Estomatología General Integral de la provincia Sancti Spíritus. Metodología: Se Realizó una investigación en sistema y servicio de salud en la provincia Sancti Spíritus de enero a noviembre del 2016. De las 21 unidades asistenciales que prestan el servicio de Estomatología General Integral, se eligieron dos, una de la zona urbana y otra de la zona rural. El muestreo aleatorio simple fue el proceder que se empleó para efectuar esta elección en cada zona. El Policlínico Tipo II del municipio Cabaiguán fue la unidad seleccionada en la zona urbana y la Clínica Estomatológica Banao del municipio Sancti Spíritus en la zona rural. La muestra fueron 388 pacientes y 24 estomatólogos. Las variables: calidad del servicio, estructura, proceso y resultado, se utilizaron métodos del nivel teórico, empírico (encuesta) y de la estadística descriptiva. Resultados: En el servicio rural los pacientes estuvieron satisfechos en un 57.8 % y en el urbano en un 51.9 %; los profesionales se mostraron medianamente satisfechos en ambos servicios con 50.0 % y 71.4 % respectivamente. Conclusiones: La calidad de la atención estomatológica en la zona urbana fue evaluada de bien y en la rural de regular. Algunos indicadores de las variables estructura y resultado se identificaron con dificultad (AU)

ABSTRACT Background: The quality of dental care is characterized in the process and factors that interfere in the provision of services, aimed at achieving good results in terms of oral health. Objective: To evaluate the quality of dental care of two General Comprehensive Stomatology services in Sancti Spíritus province. Methodology: An investigation was carried out on the system and health service in Sancti Spíritus province from January to November 2016. From 21 health care units that provide General Comprehensive Stomatology service, two were chosen, one from the urban area and the other from the rural one. The procedure used to make this choice in each zone was the Simple random sample. The Type II Polyclinic in Cabaiguán was the selected unit from the urban area and the Dental Clinic Banao in Sancti Spíritus, from the rural one. The sample consisted of 388 patients and 24 dentists. The variables: quality of service, structure, process and result, methods of theoretical, empirical (survey) and descriptive statistics were used. Results: From the rural service the patient's satisfaction represents 57.8 % and from the urban one 51.9 %; the professional's satisfaction was moderately in both services which represent 50.0 % and 71.4 % respectively. Conclusions: The quality of dental care from the urban area was evaluated as good and from the rural area as regular. Some indicators of the structure and outcome variables were identified with difficulty.

Evaluación de la calidad de la atención estomatológica de dos servicios de Estomatología General Integral. Sancti Spíritus. 2018 / Evaluation of the quality of dental care of two General Comprehensive Stomatology services. Sancti Spíritus. 2018

RESUMEN Fundamento: La calidad de la atención estomatológica está caracterizada en el proceso y factores que intervienen en la prestación de los servicios, dirigidos a alcanzar buenos resultados en lo que a salud bucal se refiere. Objetivo: Evaluar la calidad de la atención estomatológica de dos servicios de Estomatología General Integral de la provincia Sancti Spíritus. Metodología: Se Realizó una investigación en sistema y servicio de salud en la provincia Sancti Spíritus de enero a noviembre del 2016. De las 21 unidades asistenciales que prestan el servicio de Estomatología General Integral, se eligieron dos, una de la zona urbana y otra de la zona rural. El muestreo aleatorio simple fue el proceder que se empleó para efectuar esta elección en cada zona. El Policlínico Tipo II del municipio Cabaiguán fue la unidad seleccionada en la zona urbana y la Clínica Estomatológica Banao del municipio Sancti Spíritus en la zona rural. La muestra fueron 388 pacientes y 24 estomatólogos. Las variables: calidad del servicio, estructura, proceso y resultado, se utilizaron métodos del nivel teórico, empírico (encuesta) y de la estadística descriptiva. Resultados: En el servicio rural los pacientes estuvieron satisfechos en un 57.8 % y en el urbano en un 51.9 %; los profesionales se mostraron medianamente satisfechos en ambos servicios con 50.0 % y 71.4 % respectivamente. Conclusiones: La calidad de la atención estomatológica en la zona urbana fue evaluada de bien y en la rural de regular. Algunos indicadores de las variables estructura y resultado se identificaron con dificultad.

ABSTRACT Background: The quality of dental care is characterized in the process and factors that interfere in the provision of services, aimed at achieving good results in terms of oral health. Objective: To evaluate the quality of dental care of two General Comprehensive Stomatology services in Sancti Spíritus province. Methodology: An investigation was carried out on the system and health service in Sancti Spíritus province from January to November 2016. From 21 health care units that provide General Comprehensive Stomatology service, two were chosen, one from the urban area and the other from the rural one. The procedure used to make this choice in each zone was the Simple random sample. The Type II Polyclinic in Cabaiguán was the selected unit from the urban area and the Dental Clinic Banao in Sancti Spíritus, from the rural one. The sample consisted of 388 patients and 24 dentists. The variables: quality of service, structure, process and result, methods of theoretical, empirical (survey) and descriptive statistics were used. Results: From the rural service the patient's satisfaction represents 57.8 % and from the urban one 51.9 %; the professional's satisfaction was moderately in both services which represent 50.0 % and 71.4 % respectively. Conclusions: The quality of dental care from the urban area was evaluated as good and from the rural area as regular. Some indicators of the structure and outcome variables were identified with difficulty.