Subject(s)
Esophageal Neoplasms , Lymphoma, AIDS-Related , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Adult , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Esophageal Neoplasms/diagnosis , Esophageal Neoplasms/diagnostic imaging , Esophageal Neoplasms/drug therapy , Female , Humans , Lymphoma, AIDS-Related/diagnosis , Lymphoma, AIDS-Related/diagnostic imaging , Lymphoma, AIDS-Related/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnostic imaging , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Prednisone/administration & dosage , Remission Induction , Tomography, X-Ray Computed , Vincristine/administration & dosageABSTRACT
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Subject(s)
Female , Adult , Humans , Acquired Immunodeficiency Syndrome/complications , Lymphoma, AIDS-Related/diagnosis , Esophageal Neoplasms/etiology , Acquired Immunodeficiency Syndrome/diagnosis , Acquired Immunodeficiency Syndrome/drug therapy , Anti-Retroviral Agents , Esophageal Neoplasms/diagnosisABSTRACT
Fundamento y objetivo: Con el aumento de la esperanza de vida en pacientes con infección por el virus de la inmunodeficiencia humana (VIH) tras el tratamiento antirretroviral de gran actividad (TARGA), las causas de hospitalización han cambiado. Predominan ahora comorbilidades como la hepatopatía crónica, la patología cardiovascular o los efectos secundarios de los tratamientos. Nuestro objetivo es determinar las características clinicoepidemiológicas actuales de estos pacientes. Material y métodos: Estudio descriptivo y retrospectivo. Revisamos las historias clínicas de los ingresos de pacientes con infección por el VIH hospitalizados en los servicios médicos de nuestro hospital en el transcurso de un año. Resultados: Hubo 125 ingresos de 82 pacientes, un 77% varones y un 71% con infección por el virus de la hepatitis C (VHC). La edad media fue de 42 años. En el 64% la vía de transmisión fue la drogadicción parenteral. Un 36% recibían TARGA y un 51% reunían criterios sida. Los motivos de ingreso más frecuentes fueron la patologia respiratoria (32%) y las enfermedades definitorias de sida (EDS) con un 22%, de las que la tuberculosis (TBC) fue la más frecuente. Un 10% fueron ingresados en la Unidad de Cuidados Intensivos (UCI). La mortalidad fue del 11% pacientes/año. Conclusiones: La mayoría de los pacientes fueron varones, con coinfección por el VHC y usuarios de drogas vía parenteral, siendo las causas de ingreso más frecuentes las patologías respiratorias y las enfermedades oportunistas. La TBC permanece siendo la EDS más frecuente
Background and objetive: With the increasing life expectancy in human immunodeficiency virus (HIV) infected patients since the highly active antiretroviral therapy (HAART), other underlying comorbilities such as chronic liver patology, cardiovascular diseases or side effects of treatment may lead to hospitalization. The purpose of this study is to determine the clinical and epidemiological characteristics of these patients. Material and methods: A descriptive-retrospective study. We reviewed the clinical records of patients with HIV infection admitted in our medical departments through a year. Results: There were 125 hospitalizations of 82 patients. 77% were males and 71% had hepatitis C virus (HCV) infection. The median age was 42 years. 64% HIV infection had been acquired by sharing material for intravenous drug use. A 36% were receiving HAART and 51% had AIDS. The respiratory tract patology (32%) and AIDS-defining illnesses (22%) were the most frequent causes of hospitalization, and the main opportunistic disease was tuberculosis (TBC). Ten per cent were admitted in the Intensive Care Unit. Mortality rate was 11% patients/year. Conclusions: Most of the patients were male, drug users and HCV positive, and the admissions to hospital were mostly due to respiratory patology and opportunistic diseases. TBC remains like the most frequent AIDS-defining illness
Subject(s)
Male , Female , Adult , Humans , Morbidity Surveys , Liver Diseases/complications , HIV Infections/epidemiology , HIV Infections/mortality , Comorbidity , Opportunistic Infections/complications , Opportunistic Infections/epidemiology , Liver Diseases/epidemiology , Liver Diseases/mortality , Retrospective Studies , Respiratory Tract Diseases/complications , Respiratory Tract Diseases/epidemiology , Respiratory Tract Diseases/mortality , Acquired Immunodeficiency Syndrome/epidemiology , Acquired Immunodeficiency Syndrome/mortality , Myocardial Ischemia/complications , Myocardial Ischemia/epidemiologyABSTRACT
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No disponible
Subject(s)
Male , Adult , Humans , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/therapy , Phenytoin/adverse effects , Embolization, Therapeutic/methods , Dipyrone/therapeutic use , Diagnosis, Differential , Valproic Acid/therapeutic use , Clavulanic Acid/therapeutic use , Anticonvulsants/adverse effects , Anticonvulsants/therapeutic use , Fever/complications , Exanthema/complications , Dermatitis, Exfoliative/complications , Dermatitis, Exfoliative/diagnosisABSTRACT
BACKGROUND AND OBJECTIVE: With the increasing life expectancy in human immunodeficiency virus (HIV) infected patients since the highly active antiretroviral therapy (HAART), other underlying comorbilities such as chronic liver pathology, cardiovascular diseases or side effects of treatment may lead to hospitalization. The purpose of this study is to determine the clinical and epidemiological characteristics of these patients. MATERIAL AND METHODS: A descriptive-retrospective study. We reviewed the clinical records of patients with HIV infection admitted in our medical departments through a year. RESULTS: There were 125 hospitalizations of 82 patients. 77% were males and 71% had hepatitis C virus (HCV) infection. The median age was 42 years. 64% HIV infection had been acquired by sharing material for intravenous drug use. A 36% were receiving HAART and 51% had AIDS. The respiratory tract pathology (32%) and AIDS-defining illnesses (22%) were the most frequent causes of hospitalization, and the main opportunistic disease was tuberculosis (TBC). Ten per cent were admitted in the Intensive Care Unit. Mortality rate was 11% patients/year. CONCLUSIONS: Most of the patients were male, drug users and HCV positive, and the admissions to hospital were mostly due to respiratory patology and opportunistic diseases. TBC remains like the most frequent AIDS-defining illness.
Subject(s)
AIDS-Related Opportunistic Infections/epidemiology , HIV Infections/epidemiology , HIV-1 , Adult , Anti-Retroviral Agents/therapeutic use , Cause of Death , Female , HIV Infections/drug therapy , Hospital Mortality , Humans , Inpatients/statistics & numerical data , Male , Morbidity , Retrospective Studies , Spain/epidemiologySubject(s)
Acquired Immunodeficiency Syndrome/complications , Cerebral Infarction/microbiology , HIV-1 , Neurosyphilis/complications , Paresis/etiology , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/drug therapy , Acquired Immunodeficiency Syndrome/diagnosis , Anti-Bacterial Agents/therapeutic use , Cerebral Infarction/diagnosis , Cerebral Infarction/drug therapy , Humans , Magnetic Resonance Angiography , Male , Middle Aged , Neurosyphilis/diagnosis , Neurosyphilis/drug therapy , Paresis/diagnosis , Paresis/therapy , Penicillin G/therapeutic use , Treatment OutcomeSubject(s)
Abscess/microbiology , Fever/microbiology , Neck Pain/microbiology , Streptococcal Infections/pathology , Streptococcus pyogenes/isolation & purification , Abscess/diagnostic imaging , Abscess/therapy , Aged , Anti-Bacterial Agents/therapeutic use , Drainage/methods , Female , Fever/diagnostic imaging , Fever/therapy , Humans , Neck Pain/diagnostic imaging , Neck Pain/therapy , Streptococcal Infections/diagnostic imaging , Streptococcal Infections/therapy , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
BACKGROUND: Analysis of the main infections complications in drug-dependents and their relation between the way of consumption and sexual activity; the detoxification treatments used are taken into consideration. MATERIAL AND METHODS: We studied the patients admitted to the HDU (Hospital Detoxification Unit) between 1991 and 1995 revising their Clinical Histories with a protocol made for the occasion; the statistical calculations were subjected to the SPSS program, applying the Fisher's and Chi-square tests. RESULTS: 458 patients were included (males = 365); drug were taken intravenously in 290 cases (distribution from 1991 to 1995: 61, 92, 72, 88-p = 0.05), smoked in 120 cases (distribution: 18, 57, 60, 67-p = 0.01), inhaled in 29 cases (2, 16, 4, 6-p = 0.01) and taken orally 176 cases (29, 50, 46, 50). The Hepatitis B Virus (HBV) was positive in 186 of 403; the Hepatitis C Virus (HCV) was positive in 259 of 374 (known = 115/discovered = 144) and incidence with respect to the human immunodeficiency virus (HIV) has p < 0.000001; HIV was positive in 85 (known = 69). Sexually Transmitted Diseases (STD) were present in 94 patients, 27 of whom were women (p = 0.03), HBV(+) = 38, HCV(+) = 49 and HIV(+) = 52 (p = 0.02). Candida infections is present in 31 HIV(+). Phlebitis antecedents are found in 79 (424), 48 of whom were HBV(+) (p = 0.00003), 60 were HCV(+) (p = 0.000008) and 29 HIV(+) (p = 0.00003). The patients were mainly treated with Clonidina (450) and tricyclic antidepressants (242). CONCLUSIONS: In our study, we observe the increase of intravenous drug users, being phlebitis the most frequent antecedent in HBV(+), HCV(+) and HIV(+); we have also detected a higher number of STD both in these groups and in women as well.
Subject(s)
HIV Infections/epidemiology , Hepatitis, Viral, Human/epidemiology , Substance-Related Disorders/epidemiology , Female , HIV Infections/complications , Hepatitis B/complications , Hepatitis B/epidemiology , Hepatitis C/complications , Hepatitis C/epidemiology , Hepatitis, Viral, Human/complications , Humans , Male , Spain/epidemiology , Substance Abuse, Intravenous/complications , Substance Abuse, Intravenous/epidemiology , Substance-Related Disorders/complicationsABSTRACT
Three cases of AIDS in patients older than 60 years of age are presented and are characterized by the delay in diagnosis even in the face of suggestive clinical manifestations because of the lack of suspicion leading to fatal short term evolution in all the cases. The importance of HIV infection and its characteristics at this age are discussed. Transfusion is the most frequent method of transmission. The clinical manifestations do not differ from those of other ages with neurological and psychiatric manifestations being significant as a form of presentation. Evolution is usually rapidly progressive. The need to suspect HIV infection is emphasized in elderly patients when presenting typical AIDS pathology or atypical dementia or rapid evolution specially if pertaining to a risk group.
Subject(s)
Acquired Immunodeficiency Syndrome/diagnosis , HIV-1 , AIDS Dementia Complex/diagnosis , Acquired Immunodeficiency Syndrome/transmission , Aged , Animals , Coccidiosis/diagnosis , Cryptosporidiosis/diagnosis , Diagnosis, Differential , Diagnostic Errors , Female , Humans , Isospora , Male , Middle Aged , Opportunistic Infections/diagnosis , Pneumonia, Pneumocystis/diagnosis , Time Factors , Tuberculosis, Lymph Node/diagnosisABSTRACT
We report a patient with cholestasis associated with prostatic carcinoma. When metastasic hepatic occupation, bile tract obstruction and other causes were ruled out, cholestasis was attributed to carcinoma itself as a paraneoplastic syndrome. This possibility has been previously reported as exceptional in prostatic carcinoma and in other tumors. We review cholestasis associated with tumors and we discuss its possible etiological and pathogenetical mechanisms.