ABSTRACT
Anomalous origin of the left coronary artery from the opposite sinus of Valsalva with an intramural aortic course is a rare congenital anomaly with a poor prognosis. We report the case of a 14-year-old soccer player who briefly lost consciousness while sprinting. He had exertional chest pain, syncope, ischemic changes on his electrocardiogram, and elevated cardiac troponin levels. Computed tomographic angiograms showed an anomalous origin of the left coronary artery from the right sinus of Valsalva and a course through the aortic wall toward the left coronary sinus. A surgically created neo-ostium in the left coronary sinus relieved the patient's ischemia, and he resumed playing soccer after cardiac rehabilitation.
Subject(s)
Athletes , Coronary Vessels/diagnostic imaging , Electrocardiography , Sinus of Valsalva/abnormalities , Adolescent , Cardiac Surgical Procedures/methods , Coronary Angiography , Coronary Vessel Anomalies , Coronary Vessels/surgery , Humans , Male , Sinus of Valsalva/diagnostic imaging , Sinus of Valsalva/surgery , Tomography, X-Ray ComputedABSTRACT
Cardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity. Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiac profile could reflect differences in cardiac function and structure in obese and non-obese rats with myocardial infarction (MI). Whether these changes can also be reflected in a specific plasma miRNA signature as markers of cardiac damage was also evaluated. Rats were fed with either standard (3.5% fat) or high fat diet (35% fat) for 6 weeks before the induction of MI and sacrificed 4 weeks later. MI showed cardiac lipotoxicity independently of the presence of obesity, although obese and non-obese rats did not present the same cardiac lipid profile at mitochondrial level. Several cardiac lipid species in mitochondria, including cardiolipins and triglycerides, were associated with myocardial fibrosis, with mitochondrial triglyceride levels being independently associated with it; this supports that lipotoxicity can affect cardiac function. MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. This could support that lipotoxicity could affect heart function by modulating plasma miRNAs.
Subject(s)
Cardiomyopathies/genetics , Lipids/analysis , MicroRNAs/genetics , Obesity/genetics , Signal Transduction/genetics , Animals , Cardiolipins/analysis , Cardiomyopathies/metabolism , Cardiomyopathies/physiopathology , Diet, High-Fat/adverse effects , Fibrosis , Gene Expression Profiling/methods , Male , MicroRNAs/blood , Myocardial Infarction/etiology , Myocardial Infarction/genetics , Myocardial Infarction/metabolism , Myocardium/metabolism , Myocardium/pathology , Obesity/physiopathology , Rats, Wistar , Triglycerides/analysisABSTRACT
No disponible
