Linfoma de Hodgkin esternal / Hodgkin's sternal lymphoma

El linfoma de Hodgkin (LH) puede afectar a múltiples órganos y encontrarse en diferentes localizaciones anatómicas. Una localización poco frecuente es el sistema esquelético. Los linfomas primarios óseos son un grupo heterogéneo de patologías que abarcan los LH y los linfomas no Hodgkin (LNH) y que conforman del 3 al 5% de los linfomas de localización extraganglionar. Se presenta un caso clínico de linfoma esternal con afectación mediastínica y su tratamiento posterior en una mujer de 43 años (AU)

Hodgkin's lymphoma can affect multiple organs and be found in several anatomical locations. A rare location is in the skeletal system. Primary bone lymphomas are a heterogeneous group of tumors, including Hodgkin's lymphoma and non-Hodgkin's lymphoma, these accounting for 3-5% of the lymphomas having an extranodal location. A clinical case is presented of a lymphoma involving the sternum, with mediastinal involvement and its subsequent treatment in a 43-year old woman (AU)

[Radiation induced tumors]. / Tumores radioinducidos.

Radiations at cellular level produce different effects, depending on type of radiation and irradiated tissue. The radiation-induced cancers are associated to non-letals genetics mutations, and to classify like radiation induced tumors is necessary that appear in the treatment volume, a long latency period (years), histolo-different to the primary lesion, enough doses quantitatively and that exists a greater incidence in the irradiated populations. The genetics mutations affect at tumoral suppressors gen(Gen RB I, p53, BRCA I, BRCA 2) and repressors gen (hMSH 2, hMLH I,...), they could be longer and multifocals mutations, and produce lack of cellular control and a greater predisposition to develop tumors and a probable risk of increment of radiosensitivity. We present some of the more representatives studies about radiation-induced tumors.

A multivariant study of pituitary adenoma, obtainment of two logistic regression equations as an auxiliary support in the diagnosis of these tumors.

A multivariant analysis was carried out in 120 patients with pituitary adenoma (prolactinoma, HGH-secreting adenoma and nonfunctional adenoma) and an equation was obtained concerning the prolactinoma (whose independent variables were age, galactorrhea, impotence, stage, and pretreatment secretion of ACTH) and another one concerning the nonfunctional adenoma (with age evolution time, visual disturbance evolution and galactorrhea as independent variables). These equations are useful in the differential diagnosis. The internal validity of both equations was obtained by calculating the ROC curve and determining sensibility, specificity and predictive values at the "optimum point" of this curve.