ABSTRACT
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Subject(s)
Humans , Carcinoma/pathology , Adenocarcinoma/pathology , Colonic Neoplasms/pathology , Prognosis , Diagnosis, DifferentialABSTRACT
Lymphoepithelioma-like colon carcinoma (LELC) is rare. The Epstein-Barr virus (EBV) hasn´t been implicated in the pathogenesis of LELC of the colon, but they may in fact be more strongly associated with MSI. Its treatment is identical to adenocarcinoma. However, lymphocyte infiltration and microsatellite instability have been associated with better prognosis.
Subject(s)
Adenocarcinoma/pathology , Carcinoma/pathology , Colonic Neoplasms/pathology , Killer Cells, Natural/pathology , T-Lymphocytes/pathology , Adenocarcinoma/virology , Carcinoma/virology , Colonic Neoplasms/virology , Herpesvirus 4, Human , Humans , Lymphocytes, Tumor-Infiltrating/pathology , PrognosisABSTRACT
Introducción: el objetivo de este trabajo es presentar un caso de empalamiento a través de la región inguinal. Las heridas por empalamiento son infrecuentes y, en ocasiones, de extrema gravedad, necesitan de una actuación rápida del personal médico de urgencias y del cirujano. Caso clínico: se presenta el caso de un varón de 40 años que sufrió un accidente laboral con empalamiento de un hierro de ferralla a través de la región inguinal derecha, el cuerpo extraño penetró en la cavidad abdominal. Se expone ampliamente el caso clínico, así como los procedimientos realizados en el diagnóstico y el tratamiento de este tipo de lesiones. Conclusiones: las heridas por empalamiento son infrecuentes y suponen un reto para el personal médico que atiende al afectado desde el primer momento, tanto por lo complejas que pueden ser, como por la necesidad de una actuación rápida, sin poder conocer a priori, en muchas de las situaciones, la extensión verdadera de las lesiones, que se evidenciará durante el posible acto operatorio(AU)
Introduction: the objective of this paper was to present a case of impalement through the inguinal region. The impalement injuries are infrequent and sometimes extremely serious. These injuries require prompt action of the emergency medical personnel and surgeon. Clinical case: a forty-year old man, who had an occupational accident resulting in impalement of an iron rebar through the right inguinal region and penetrating abdominal cavity. The clinical case and the procedures performed in the diagnosis and treatment of these injuries were presented in detail. Conclusions: The impalement injuries are rare and represent a challenge to the medical staff that treat the patient from the very beginning, because they can be very complex and require fast action and treatment. In many cases, the real dimension and severity of lesions at first is unknown and can only be assessed during surgery(AU)
Subject(s)
Humans , Male , Adult , Abdominal Injuries/diagnosis , Accidents, Occupational , Emergencies , Inguinal Canal/injuries , Wounds, Stab/surgery , Abdominal Injuries/therapyABSTRACT
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Subject(s)
Humans , Male , Middle Aged , Liver Failure, Acute/etiology , Simplexvirus/pathogenicity , Hepatitis, Viral, Human/diagnosis , Diagnosis, Differential , Cholecystitis, Acute/diagnosisABSTRACT
AIMS: Liver cirrhosis is a risk factor for osteoporosis. However, the pathogenesis of the bone mass loss in patients with alcohol-induced cirrhosis (AC) is not well understood. Serum concentrations of soluble tumour necrosis factor receptor (sTNF-R55), neopterin and soluble interleukin 2 receptor (sIL-2R), activation markers of cellular immunity, correlate with clinical activity and severity of the AC. The aim of this study is to evaluate the association of these soluble markers with the development of osteoporosis in patients with AC. METHODS: We studied 33 consecutive patients with AC and 24 healthy volunteers. Bone mineral density (BMD) was measured by X-ray absorptiometry in the lumbar spine (LS) and femoral neck (FN). Neopterin was measured by radioimmunoassay. Serum concentrations of sTNF-R55 and sIL-2R were measured by enzyme immunoassay. We also determined serum levels of osteocalcin and bone alkaline phosphatase as biochemical markers of bone formation, and deoxypyridinoline urinary excretion (D-Pyr) as marker of bone resorption. RESULTS: Patients with AC had reduced BMD (expressed as z-score) in all sites (LS: P < 0.001 and FN: P < 0.05). Serum concentrations of sTNF-R55 were significantly higher in patients with both AC and osteoporosis than in those with only AC (P < 0.001). Serum levels of sTNF-R55 positively correlated with D-Pyr urinary excretion (r = 0.354; P = 0.01). Serum levels of sIL-2R were significantly higher in patients with both AC and osteoporosis than in those with only AC (P < 0.05). CONCLUSIONS: There is a relation between activation of the cellular immunity and osteoporosis in AC. Bone mass loss could be related to the increased bone resorption found in these patients.
