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1.
Rev. mex. anestesiol ; 44(1): 66-69, ene.-mar. 2021.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1347718

ABSTRACT

Resumen: Se presenta el caso de paciente masculino, de 60 años, programado para resección transuretral de próstata. Como antecedentes destacan enfermedad de Steinert e implantación de marcapasos. La enfermedad de Steinert es el antecedente principal que guiará nuestra práctica anestésica y, tras valorar el tipo de intervención prevista, se decide anestesia locorregional, dadas las potenciales complicaciones que pueden presentar estos pacientes con la anestesia general. La conducta anestésica de los pacientes con enfermedad de Steinert supone un reto para el anestesiólogo tanto por la gran cantidad de complicaciones que pueden aparecer en el intra- y en el postoperatorio, como por la baja frecuencia de esta enfermedad. Además, el estrés quirúrgico y las técnicas utilizadas pueden interferir en el curso de la enfermedad. Por todo ello, el abordaje y los cuidados intra- y postoperatorios se deben planificar y seleccionar con cuidado con el fin de obtener los mejores resultados y extremar la seguridad del paciente.


Abstract: A 60-year-old man with prostatic hypertrophy was scheduled for transurethral resection of the prostate. Steinert's disease and implantation of a pacemaker were his previous pathology. Being Steinert's disease the most relevant clinical characteristic and the type of intervention urologist has planned, we decide locoregional anesthesia technique, avoiding the potential complications that these patients may present with general anesthesia. The anesthetic management of Steinert's disease patients is a challenge for the anesthesiologist both due to the large number of complications that may appear during intra- and postoperative time as well as the low frequency of this pathology. In addition, surgical stress and the techniques we use can interfere with the course of the disease. Therefore, the approach and immediate intra-and postoperative care should be carefully planned and selected in order to obtain the best results and maximize patient safety.

2.
J Emerg Med ; 44(1): 269-79, 2013 Jan.
Article in English | MEDLINE | ID: mdl-23026366

ABSTRACT

BACKGROUND: Although anterior shoulder dislocation is common in everyday practice in Emergency Departments, bilateral presentation is a rare entity. OBJECTIVES: The aim of this article is to report two additional cases of this rare injury and to introduce a new mechanism that can produce it. We made an exhaustive review of the literature and found 68 cases in printed publications. Also, we analyzed the mechanism of injury and the presence of predisposing factors, and propose a new etiological-mechanical classification. CASE REPORT: One case occurred after a trivial fall, and the other was produced by a mechanism not previously reported: the patient pushed strongly forward, expecting a resistance and finding none, his arms kept the forward movement and the shoulders dislocated. DISCUSSION: This lesion has a bimodal distribution, affecting mainly men (70%) with a mean age of 33.5 years, whereas in women, the average age is 57 years. The most common cause is trauma (50%), followed by muscle contractions (37%) due to seizures of different causes (epileptic, hypoglycemia, toxic, or hypoxic) or electrocution. In 15.7% of the cases, the diagnosis of bilateral anterior dislocation was not acute (<3 weeks), and in virtually all of these cases it was not traumatic. CONCLUSION: The bilateral anterior shoulder dislocation may not be as rare as previously thought and must be taken into account in emergency services. The authors propose a new etiological-mechanical classification. Also, the importance of radiologic diagnosis must be highlighted.


Subject(s)
Shoulder Dislocation/etiology , Adolescent , Aged , Female , Humans , Male , Radiography , Shoulder Dislocation/diagnostic imaging , Shoulder Dislocation/pathology
3.
J Immunol ; 170(4): 2147-52, 2003 Feb 15.
Article in English | MEDLINE | ID: mdl-12574387

ABSTRACT

CXCL12 (stromal cell-derived factor-1) is a potent CXC chemokine that is constitutively expressed by stromal resident cells. Although it is considered a homeostatic rather than an inflammatory chemokine, CXCL12 has been immunodetected in different inflammatory diseases, but also in normal tissues, ant its potential functions and regulation in inflammation are not well known. In this study, we examined the cellular sources of CXCL12 gene expression and the mechanism and effects of its interactions with endothelial cells in rheumatoid arthritis synovium. We show that CXCL12 mRNA was not overexpressed nor induced in cultured rheumatoid synoviocytes, but it specifically accumulated in the rheumatoid hyperplastic lining layer and endothelium. CXCL12 gene expression was restricted to fibroblast-like synoviocytes, whereas endothelial cells did not express CXCL12 mRNA, but displayed the protein on heparitinase-sensitive factors. CXCL12 colocalized with the angiogenesis marker alpha(v)beta(3) integrin in rheumatoid endothelium and induced angiogenesis in s.c. Matrigel plugs in mice. The angiogenic activity of rheumatoid synovial fluid in vivo was abrogated by specific immunodepletion of CXCL12. Our results indicate that synoviocyte-derived CXCL12 accumulates and it is immobilized on heparan sulfate molecules of endothelial cells, where it can promote angiogenesis and inflammatory cell infiltration, supporting a multifaceted function for this chemokine in the pathogenesis of rheumatoid arthritis.


Subject(s)
Arthritis, Rheumatoid/immunology , Arthritis, Rheumatoid/physiopathology , Chemokines, CXC/biosynthesis , Endothelium, Vascular/immunology , Neovascularization, Pathologic/immunology , Synovial Membrane/immunology , Synovial Membrane/metabolism , Animals , Arthritis, Rheumatoid/metabolism , Cell Line , Cells, Cultured , Chemokine CXCL12 , Chemokines, CXC/physiology , Collagen , Diffusion Chambers, Culture , Drug Combinations , Endothelium, Vascular/cytology , Endothelium, Vascular/metabolism , Female , Humans , Laminin , Mice , Mice, Inbred BALB C , Neovascularization, Pathologic/metabolism , Organ Specificity/immunology , Proteoglycans , Receptors, CXCR4/biosynthesis , Skin/blood supply , Skin/immunology , Skin/physiopathology , Synovial Fluid/immunology , Synovial Membrane/cytology
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