ABSTRACT
Scedosporium apiospermum is a filamentous fungus that can cause cutaneous or extracutaneous disease. A large number of cases have been published over the last decades, mainly in patients immunocompromised as a result of their disease or treatment. These kinds of infections can progress rapidly and become disseminated, leading to very serious or even fatal complications. We report two new cases of skin infection by Scedosporium apiospermum from our hospital.
Subject(s)
Antifungal Agents/therapeutic use , Dermatomycoses/immunology , Immunocompromised Host , Naphthalenes/administration & dosage , Pyrimidines/administration & dosage , Scedosporium/isolation & purification , Triazoles/administration & dosage , Abscess/drug therapy , Abscess/surgery , Aged , Dermatomycoses/diagnosis , Dermatomycoses/drug therapy , Humans , Male , Scedosporium/drug effects , Terbinafine , VoriconazoleABSTRACT
BACKGROUND: Cardiovascular risk factors have been assessed with some skin diseases such as alopecia and psoriasis. Recently, a case-control study found that lichen planus (LP) was associated with dyslipidaemia in a large series of patients. However, no data were presented about lipid values in patients and controls. OBJECTIVE: The objective of this case-control study was to evaluate lipid levels in men and women with lichen planus and in healthy controls, excluding lichenoid drug eruption and treatment for LP such as systemic corticosteroids, retinoid acid or methotrexate. PATIENTS AND METHODS: This case-control study included 160 patients, 80 with LP (40 men and 40 women) and 80 controls consecutively admitted to the outpatient clinic in Dermatology department of San Cecilio Hospital, Granada, Spain. RESULTS: Patients with LP presented higher significant triglycerides values (145.9 vs. 101.5 mg/dL P = 0.0007), total cholesterol values (197.7 vs. 178.4 mg/dL P = 0.001), LDL-C values (120.8 vs. 100.9 mg/dL P < 0.0001) and lower HDL-C values (55.3 vs. 61.9 mg/dL P = 0.004) vs. controls. Adjusted OR for dyslipidaemia in patients with LP was 3.03 (95% confidence interval: 1.49-6.17, P = 0.002). CONCLUSION: The results obtained in this study indicate an association between LP and dyslipidaemia. Lipid levels screening in men or women with LP may be useful to detect individuals at risk and start preventive treatment against the development of cardiovascular disease.
Subject(s)
Lichen Planus/blood , Lipids/blood , Adult , Case-Control Studies , Female , Humans , Male , Middle AgedABSTRACT
Cutaneous leishmaniasis is a group of diseases with vast clinical polymorphism produced by protozoa of the genus Leishmania, that is acquired through the bite of sandflies. It is an endemic zoonosis in Spain, being the dog the main reservoir. In our country all forms of leishmaniasis are due to Leishmania infantum species, that usually produces mild lesions in uncovered areas, mainly in children. We report an imported case of cutaneous leishmaniasis in a Senegal patient that presented clinical characteristics unusually different from the typical lesions produced by L. infantum that we are used to evaluate. The lesions were multiple, large, very inflammatory and exudative; these differences may be attributed to the type of endemic leishmania in Senegal: L. major. Given the increase in immigrant population and travels abroad, it is essential for the dermatologist to become familiar with skin diseases of tropical areas that, in the near future, will be more common in daily clinical practice.
Subject(s)
Leishmaniasis, Cutaneous/pathology , Transients and Migrants , Adult , Humans , Male , Senegal/ethnology , SpainABSTRACT
Las leishmaniasis cutáneas son un grupo de enfermedades con gran polimorfismo clínico, producidas por protozoos del género Leishmania, que se adquieren a través de la picadura de mosquitos flebotomos. Se trata de una zoonosis endémica en España, actuando el perro como principal reservorio. Todas las formas de leishmaniasis en nuestro país se deben a la especie Leishmania infantum, que suele producir lesiones de carácter leve, en áreas descubiertas, afectando sobre todo a los niños. Se presenta el caso de una leishmaniasis cutánea importada, en un paciente de Senegal, que presentaba unas características clínicas algo distintas de las lesiones típicas producidas por L. infantum que estamos más habituados a ver en nuestro país, ya que las lesiones eran múltiples, de gran tamaño, muy inflamatorias y exudativas, diferencias que creemos pueden atribuirse al tipo de leishmania endémica en Senegal: L. major. Con el aumento de la población inmigrante y los viajes al extranjero, resulta indispensable para el dermatólogo el familiarizarse con cuadros de dermatología tropical que en un futuro muy próximo se harán habituales en la práctica clínica diaria
Cutaneous leishmaniasis is a group of diseases with vast clinical polymorphism produced by protozoa of the genus Leishmania, that is acquired through the bite of sandflies. It is an endemic zoonosis in Spain, being the dog the main reservoir. In our country all forms of leishmaniasis are due to Leishmania infantum species, that usually produces mild lesions in uncovered areas, mainly in children. We report an imported case of cutaneous leishmaniasis in a Senegal patient that presented clinical characteristics unusually different from the typical lesions produced by L. infantum that we are used to evaluate. The lesions were multiple, large, very inflammatory and exudative; these differences may be attributed to the type of endemic leishmania in Senegal: L. major. Given the increase in immigrant population and travels abroad, it is essential for the dermatologist to become familiar with skin diseases of tropical areas that, in the near future, will be more common in daily clinical practice
Subject(s)
Male , Adult , Humans , Leishmaniasis, Cutaneous/complications , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/therapy , Leishmania infantum/isolation & purification , Leishmania infantum/pathogenicity , Leishmania major/isolation & purification , Leishmania major/microbiology , Biopsy , Spain/epidemiology , Epidemiological Monitoring , Diagnosis, Differential , Meglumine/therapeutic useABSTRACT
No disponible
Subject(s)
Adult , Female , Humans , Parvovirus B19, Human , Erythema Infectiosum , Vasculitis, Leukocytoclastic, Cutaneous , Parvoviridae Infections , Purpura , Hand , FootABSTRACT
Sinus histiocytosis with massive lymphadenopathy is an entity that exceptionally appears as a purely cutaneous disease. We described 2 cases of this form with spontaneous involution. Histology showed a polymorphic infiltrate in the dermis and hypodermis composed of large histiocytes with lymphophagocytosis, neutrophils and plasma cells. Immunohistochemical stains demonstrated the positivity of histiocytes for protein S-100 and MAC 387.
