ABSTRACT
El cáncer colorrectal (CCR) es la tercera neoplasia más frecuente a un nivel mundial. El riesgo de CCR depende de factores genéticos y ambientales que interactúan en el proceso de carcinogénesis mediante mecanismos epigenéticos. Aunque sólo el 25 % de los CCR presenta agregación familiar, en todos los casos de CCR entre los que se incluyen los esporádicos se producen mutaciones genéticas que desencadenan tres tipos distintos de vías moleculares de carcinogénesis que influyen en un comportamiento tumoral diferente. El conocimiento de los genes y las vías moleculares implicados en el desarrollo del CCR tiene unas aplicaciones clínicas debido a que ayuda a definir el pronóstico, a elaborar un consejo genético en caso de síndromehereditario y a diseñar un plan terapéutico más específico de acuerdo a las características moleculares del tumor. Por otro lado, según la teoría de las células madre, una célula madre del epitelio colónico con una acumulación de aberraciones genéticas puede ser la célula origen del CCR. El diseño de nuevos fármacos dirigidos contra marcadores de las células madre del CCR pueden potenciar la respuesta de la quimioterapia convencional y disminuir las recurrencias locales y metástasis a distancia (AU)
Colorectal cancer is the third most common cancer wordlwide. Relative CRC risk is defined by genetic and environmental factors contributing to carcinogenesis by epigenetic mechanisms. Though only a 25 % CRC has been determined to have a familiar agregation with an important genetic component, all cases of CRC including sporadic ones present genetic aberrations that initiate three distinct molecular pathways of carcinogenesis implicating in different tumoral behaviours. Investigations about genes and molecular pathways implicated in the development of CRC have clinic aplications due to it could contribute to determine prognosis, elaborate a genetic conseling in case of familiar agregation and design therapeutic strategies according with molecular characteristics of tumor. On the other hand, A stem cell located in colonic epithelium with an acumulation of genetic mutations could be the cell that initiates the origin of CRC. The design of stem cell-targeted drugs could enhance reponsiveness to traditional therapeutic strategies and reduce local recurrence and metástasis (AU)
Subject(s)
Humans , Colorectal Neoplasms/genetics , Colorectal Neoplasms, Hereditary Nonpolyposis/genetics , Genetic Markers , Genetic Predisposition to Disease , Epigenesis, Genetic , Stem Cells/pathologyABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Adolescent , Aged , Pancreatitis/parasitology , Echinococcosis/diagnosis , Acute DiseaseSubject(s)
Echinococcosis/diagnosis , Pancreatitis/parasitology , Acute Disease , Adolescent , Aged , Anthelmintics/therapeutic use , Cholangiography , Cholangiopancreatography, Endoscopic Retrograde , Cholecystectomy , Cholestasis, Extrahepatic/complications , Cholestasis, Extrahepatic/parasitology , Combined Modality Therapy , Drainage , Echinococcosis/diagnostic imaging , Echinococcosis/surgery , Echinococcosis, Hepatic/complications , Echinococcosis, Hepatic/diagnosis , Echinococcosis, Hepatic/drug therapy , Echinococcosis, Hepatic/surgery , Female , Humans , Male , Pancreatitis/diagnosis , Pancreatitis/diagnostic imaging , Pancreatitis/etiology , Pancreatitis/surgery , Radiography, Interventional , Sphincterotomy, EndoscopicABSTRACT
A clinical study on the incidence of malnutrition among hospital patients with digestive system surgical disease is presented. Eighty-one patients were admitted into this trial and underwent preoperative nutritional assessment, which permitted classifying the type and intensity of malnutrition, in order to develop the appropriate postoperative nutritional support. There was high malnutrition incidence among both cancer and non-cancer patients, reaching levels of 80%.
Subject(s)
Nutritional Status , Protein-Energy Malnutrition/epidemiology , Stomach Diseases/complications , Adult , Aged , Cohort Studies , Female , Humans , Male , Middle Aged , Preoperative Care , Protein-Energy Malnutrition/etiologyABSTRACT
Presentation of the first results obtained from our study, the objective of which is to discover a benefit in the nutritional state following the administration of a greater amount of branched chain amino-acids in parenteral solutions using the peripheral method, during the first 7 days of the postoperative period, in neoplastic patients subjected to surgery of the digestive tract.
