Subject(s)
Arteriosclerosis/diagnostic imaging , Breast Diseases/diagnostic imaging , Breast/blood supply , Calcinosis/diagnostic imaging , Macular Degeneration/diagnosis , Mammography , Aged , C-Reactive Protein/metabolism , Female , Homocysteine/blood , Humans , Middle Aged , Tomography, Optical CoherenceABSTRACT
BACKGROUND: To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors. METHODS: Dynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2. RESULTS: Homogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (