Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Chemotherapy ; 61(5): 249-55, 2016.
Article in English | MEDLINE | ID: mdl-26950478

ABSTRACT

New compounds with antituberculosis activity and their combination with classic drugs have been evaluated to determine possible interactions and antagonism. The aim of this study was to evaluate the in vitro activity of Casiopeínas® copper-based compounds (CasIIIia, CasIIIEa, and CasIIgly) alone and combined with isoniazid (INH), rifampicin, or ethambutol (EMB) against resistant and susceptible Mycobacterium tuberculosis. Seventeen clinical M. tuberculosis isolates (5 multi-drug resistant and 2 resistant to INH and/or EMB) were subjected to determination of the minimal inhibitory concentration (MIC) by the resazurin microtiter assay and combination assessment by the resazurin drug combination microtiter assay. The Casiopeínas® alone showed a remarkable effect against resistant isolates with MIC values from 0.78 to 12.50 µg/ml. Furthermore, a synergistic effect mainly with EMB is shown for both resistant and susceptible clinical isolates. Casiopeínas® are promising candidates for future investigation into the development of antituberculosis drugs, being one of the first examples of essential metal-based drugs used in this field.


Subject(s)
Antitubercular Agents/pharmacology , Coordination Complexes/pharmacology , Copper/chemistry , Mycobacterium tuberculosis/drug effects , Tuberculosis/microbiology , Antitubercular Agents/chemistry , Antitubercular Agents/therapeutic use , Coordination Complexes/chemistry , Coordination Complexes/therapeutic use , Drug Resistance, Bacterial/drug effects , Drug Synergism , Ethambutol/pharmacology , Ethambutol/therapeutic use , Humans , Isoniazid/pharmacology , Isoniazid/therapeutic use , Macrophages/cytology , Macrophages/drug effects , Macrophages/microbiology , Microbial Sensitivity Tests , Mycobacterium tuberculosis/isolation & purification , Rifampin/pharmacology , Rifampin/therapeutic use , Tuberculosis/drug therapy
SELECTION OF CITATIONS
SEARCH DETAIL
...