ABSTRACT
PURPOSE: Most studies assessing the value of the university admissions test (UAT) to predict academic performance at the end of a medical course were carried out on lecture-based medical courses. However, the association between performance in the UAT with academic achievement at the end of medical course in a problem-based learning (PBL) medical hybrid curriculum remains controversial. The aim of this study was to correlate marks in the UAT with those obtained in the Organized Structured Clinical Examination (OSCE), in the progress testing (PT), and in the final marks of the clerkship (FMC). METHODS: We used data from 48 medical students. A single and a multiple dependency studies were performed to assess bivariate and multiple correlation between the UAT or the essay scores (dependent variables) and the OSCE, PT, and FMC (independent variables). Pearson test, multiple linear regression, and ANOVA tests were used and a p-value < 0.05 was considered significant. RESULTS: In the bivariate analysis, only the UAT and FMC marks were correlated (r=0.34; p=0.02). However, the multiple dependency study showed a moderate correlation among UAT, OSCE, PT, and FMC marks (r=0.46; p=0.01). No correlation was found between the essay scores and PT, FMC, and OSCE scores. CONCLUSION: Our study shows that UAT marks, but not essay scores, can predict academic achievement, particularly in terms of clinical competence (FMC) at the end of a medical course in a PBL hybrid curriculum.
ABSTRACT
Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.
Subject(s)
Antineoplastic Agents , Cell Movement/drug effects , Cell Proliferation/drug effects , Curcumin , Stomach Neoplasms/drug therapy , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Curcumin/analogs & derivatives , Curcumin/chemistry , Curcumin/pharmacology , Dose-Response Relationship, Drug , Humans , Neoplasm Invasiveness , Stomach Neoplasms/metabolism , Stomach Neoplasms/pathologyABSTRACT
Foram analisados os dados dos exames periódicos realizados nos servidores da Universidade de São Paulo, no Serviço de Medicina do Trabalho, no período de novembro de 1997 a outubro de 1998. Foram consultados 8356 prontuários médicos e anotados os seguintes dados: função, faixa etária, sexo, parâmetros vitais, exames laboratoriais, radiológicos e gráficos, hábitos de fumo e álcool, doenças pré-existentes e diagnosticads na consulta do exame periódico. As alterações mais freqüents foram dislipidemia, obesidade, hipertensão arterial e diabetes. Também foram analisadas 362 Comunicações de Acidentes do trabalho emitidas nesse período, das quais 164 correspondiam a doenças profissionais. As doenças osteoarticulares, relacionadas ao trabalho, e as perdas auditivas induzidas por ruído ocupacional, foram as mais notificadas
Subject(s)
Humans , Male , Female , Adult , Occupational Diseases , Epidemiologic Studies , Medical Examination , Occupational Health/statistics & numerical data , Weight Gain , Medical Examination , Occupational Health ServicesABSTRACT
Os autores relatam o caso de um paciente portador de fibrohistiocitoma maligno em membro inferior, cuja opção terapêutica foi a ressecção cirúrgica e radioterapia local. Esta opção terapêutica é a mais adotada nos melhores serviços e é a que apresenta, segundo a literatura, menores taxas de amputação e recidiva local do tumor (au)
Subject(s)
Humans , Female , Middle Aged , Histiocytoma, Benign Fibrous/therapy , Perna , Histiocytoma, Benign Fibrous/surgery , Histiocytoma, Benign Fibrous/diagnosisABSTRACT
Os autores apresentam um caso de peritonite pós-operatória causada por hipersensibilidade ao amido da luva cirúrgica. Chamam a atençäo para as dificuldades de ordem diagnóstica e alertam os cirurgiöes para esta possibilidade ressaltando as medidas de ordem profilática
