Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Molecules ; 21(2): 158, 2016 Jan 28.
Article in English | MEDLINE | ID: mdl-26828470

ABSTRACT

Dental caries, mainly caused by the adhesion of Streptococcus mutans to pellicle-coated tooth surfaces, is an important public health problem worldwide. A synthetic peptide (p1025) corresponding to residues 1025-1044 of the adhesin can inhibit this binding. Peptides are particularly susceptible to the biological environment; therefore, a p1025 peptide-loaded liquid crystalline system (LCS) consisting of tea tree oil as the oil phase, polyoxypropylene-(5)-polyoxyethylene-(20)-cetyl alcohol as the surfactant, and water or 0.5% polycarbophil polymer dispersions as the aqueous phase was employed as a drug delivery platform. This system exhibited anticaries and bioadhesive properties and provided a protective environment to p1025 at the site of action, thereby modulating its action, prolonging its contact with the teeth, and decreasing the frequency of administration. LCSs were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), and rheological, texture, and bioadhesive tests. PLM and SAXS revealed the presence of hexagonal liquid crystalline phases and microemulsions. Rheological analyses demonstrated that the addition of polymer dispersions favored characteristics such as shear thinning and thixotropy, hence improving buccal application. Bioadhesion tests showed that polymer dispersions contributed to the adhesion onto the teeth. Taken together, LCS could provide a novel pharmaceutical nanotechnology platform for dental caries treatment.


Subject(s)
Adhesins, Bacterial/chemistry , Dental Caries/drug therapy , Liquid Crystals/chemistry , Peptides/chemical synthesis , Saliva/drug effects , Dental Caries/microbiology , Drug Delivery Systems , Drug Design , Humans , Nanotechnology , Peptides/chemistry , Peptides/pharmacology , Rheology , Scattering, Small Angle , Streptococcus mutans/drug effects , Surface-Active Agents/chemistry , X-Ray Diffraction
SELECTION OF CITATIONS
SEARCH DETAIL
...