Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders.

Background: MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth. Objective: The aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. Results: In total, 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43, p = 0.021) points at 3 months of age. Conclusion: In this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions.

Percepção de oportunidades de aprendizado de funcionários técnico-administrativos no âmbito universitário / Perception learning opportunities of technical-administrative staff in the university scope / Percepción del personal técnico y administrativo sobre las oportunidades de aprendizaje en las universidades

Resumo Este estudo tem por objetivo identificar a percepção de oportunidades de aprendizagem e sua relação com o estilo de liderança exercido pelos funcionários técnico-administrativos no âmbito universitário, a intenção de rotatividade e capital psicológico no trabalho. Foi realizado um estudo transversal, com 102 funcionários técnico-administrativos, por meio de um questionário de autopreenchimento contendo dados referentes a idade, escolaridade, tempo de serviço na instituição e se o respondente exercia um cargo de liderança. Foram aplicadas escalas relacionadas à percepção de oportunidades de aprendizagem, avaliação do estilo gerencial, intenção de rotatividade e capital psicológico no trabalho. Os resultados revelam que os funcionários identificam oportunidades de aprendizado e a presença de três estilos gerenciais no âmbito universitário. Também se observou que os funcionários se identificam como capitais psicológicos no trabalho e possuem baixa intenção de rotatividade. Assim, este trabalho buscou ampliar a literatura ainda escassa envolvendo funcionários técnico-administrativos em âmbito universitário. (AU)

Abstract This study aimed to identify the perception of learning opportunities and its association with the leadership style of the administrative-technical staff within the university scope, the turnover intention, and the psychological capital at work. For that, this cross-sectional study was conducted with data on age, education level, length of service in the institution, and leadership position of 102 administrative and technical employees, collected by means of a self-administered questionnaire. Perceived learning opportunities, management style, turnover intention, and psychological capital at work were evaluated using scales. The results show that the administrative-technical staff identifies the three management styles and learning opportunities within the university scope. Moreover, they identify themselves as psychological capitals at work and possess low turnover intention. This study is expected to expand the (still scarce) literature on administrative and technical staff in the university context. (AU)

Resumen Este estudio tuvo como objetivo identificar las oportunidades de aprendizaje y su relación con el estilo de liderazgo adoptado por el personal técnico y administrativo en las universidades, la intención de rotación y el capital psicológico en el trabajo. Este es un estudio transversal realizado con 102 personales técnicos y administrativos mediante la aplicación de un cuestionario de autoinforme con datos sobre la edad, la educación, el tiempo de servicio en la institución y si ejercían cargo de liderazgo. Se aplicaron las escalas en cuanto a la percepción de las oportunidades de aprendizaje, la evaluación del estilo de gestión, la intención de rotación y el capital psicológico en el trabajo. Los resultados muestran que el personal identifica oportunidades de aprendizaje y la presencia de tres estilos de gestión en la universidad. También se observó que ellos se identifican como capital psicológico en el trabajo y tienen la intención de baja rotación. Por lo tanto, este estudio trató de ampliar la literatura todavía escasa, con la participación del personal técnico y administrativo en el ámbito universitario. (AU)

The T102C polymorphism of 5HT2A receptor in oral epithelial dysplasia: A pilot case-control study.

OBJECTIVE: investigate the T102C polymorphism of 5HT2A receptor in dysplasia in oral potentially malignant lesions and its association with smoking and alcohol habits. METHODS: case-control study that included patients with oral potentially malignant lesions (OPML) histopathologically diagnosed with dysplasia and healthy controls, and within these group patients with and without smoking and alcohol consumption habits. Cell samples from the oral lesions were collected with the patients previously anesthetized using disposable cytological brushes. Deoxyribonucleic acid (DNA) extraction was performed and the T102C polymorphism (rs6313) was genotyped in a real-time polymerase chain reaction (PCR) allelic discrimination assays. RESULTS: 110 individuals were included in this study (38 with dysplasia and 72 controls). The genotype (p = 0.016), allele (p = 0.020) and smoking habits (<0.001) distribution differed significantly between dysplasia and control group, where the CT and TT (C - cytosine/ T - thymine) genotype and the T allele showed a higher frequency in dysplasia (65.6, 18.8 and 84.4 %, respectively) than in controls (55.7, 4.9 and 60.7). Concerning smoking habits, the higher frequency was in the dysplasia group. The multivariate logistic regression analysis, associating variables of interest and the presence of dysplasia, showed that individuals with smoking habits present 7.58 increase risk to develop dysplasia than non-smokers; and individuals carrying the T allele for the T102C polymorphism have a 4.6 increased risk to develop oral dysplasia in OPML. CONCLUSIONS: the T102C polymorphism is associated with oral dysplasia in OPML, however, failed to show association with smoking and alcohol habits in OPML dysplasia.