ABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Collagen Diseases/diagnosis , Collagen Diseases/genetics , Collagen Diseases/pathology , Hand Dermatoses/etiology , Hand Dermatoses/therapy , Hand Dermatoses/genetics , Keratosis/pathologySubject(s)
Collagen Diseases/pathology , Hand Dermatoses/pathology , Skin Diseases, Papulosquamous/pathology , Adult , Collagen Diseases/complications , Collagen Diseases/genetics , Female , Hand Dermatoses/complications , Hand Dermatoses/genetics , Humans , Skin Diseases, Papulosquamous/complications , Skin Diseases, Papulosquamous/geneticsSubject(s)
Facial Neoplasms/diagnosis , Forehead/pathology , Neoplasms, Multiple Primary/diagnosis , Nevus, Blue/diagnosis , Skin Neoplasms/diagnosis , Facial Neoplasms/pathology , Female , Humans , Melanocytes/pathology , Middle Aged , Neoplasms, Multiple Primary/pathology , Nevus, Blue/pathology , Skin Neoplasms/pathologySubject(s)
Facial Dermatoses/etiology , Tattooing/adverse effects , Adult , Female , Humans , Sarcoidosis/etiologyABSTRACT
No disponible
No disponible
Subject(s)
Humans , Female , Adult , Tattooing/adverse effects , Sarcoidosis/diagnosis , Prednisone/therapeutic useABSTRACT
No disponible
No disponible
Subject(s)
Humans , Female , Aged , Tomography, Emission-Computed/methods , Immunohistochemistry/methods , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Large B-Cell, Diffuse/diagnosis , Antibodies, Monoclonal/therapeutic use , Diagnosis, Differential , Bone Marrow/microbiology , Biomarkers/analysis , Skin Neoplasms/classification , Skin Neoplasms/complications , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Antigens, CD20Subject(s)
Lymphoma, Large B-Cell, Diffuse/diagnosis , Skin Neoplasms/diagnosis , Aged , Aged, 80 and over , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Murine-Derived , Antineoplastic Agents/therapeutic use , Biomarkers, Tumor/analysis , Female , Humans , Leg , Lymphoma, Large B-Cell, Diffuse/chemistry , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/pathology , Neoplasm Proteins/analysis , Rituximab , Skin Neoplasms/chemistry , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Treatment FailureABSTRACT
No disponible
Subject(s)
Male , Middle Aged , Humans , Pyoderma Gangrenosum/diagnosis , Myelodysplastic Syndromes/complications , Skin Ulcer/diagnosis , Biopsy , Adrenal Cortex Hormones/therapeutic useABSTRACT
An 86-year-old woman presented with a 3-year history of an erythematous axillary lesion, which was histologically confirmed to be extramammary Paget's disease (EMPD) confined to the epidermis and adnexa. Surprisingly, spontaneous clinical regression occurred in the lesion, but Paget's cells persisted within the epidermis and adnexa on histologic examination. One year of intermittent topical chemotherapy with 5-fluorouracil resulted in ulcers that were interpreted as EMPD and completely excised. Histologic examination showed a complete absence of Paget's cells. To our knowledge, only one previous report investigated apparent spontaneous clinical resolution with histologic persistence of EMPD. We emphasize that topical 5-fluorouracil cannot be considered a safe treatment modality for EMPD, but it may be useful in certain cases in which the extent of the lesions, or the general condition of the patient, advise against surgery or radiotherapy.
Subject(s)
Antimetabolites, Antineoplastic/therapeutic use , Fluorouracil/therapeutic use , Paget Disease, Extramammary/drug therapy , Paget Disease, Extramammary/physiopathology , Skin Neoplasms/drug therapy , Skin Neoplasms/physiopathology , Administration, Topical , Aged , Aged, 80 and over , Female , Humans , Remission, SpontaneousABSTRACT
Widespread cutaneous necrosis (WCN) associated with antiphospholipid antibodies is rare. Its mechanisms have yet to be elucidated, and there are no well-established guidelines for its management. We describe a woman who had two episodes of WCN related to surgical manipulation for urinary tract obstruction and urinary tract infection. Lupus anticoagulant was always positive. In the second episode anticardiolipin antibodies were elevated, and protein C levels were temporarily decreased. We found only ten previously reported cases of WCN associated with antiphospholipid antibodies, none of which were related to surgical manipulation.
Subject(s)
Antiphospholipid Syndrome/complications , Postoperative Complications , Skin/pathology , Urinary Tract Infections/complications , Antibodies, Anticardiolipin/analysis , Female , Humans , Lupus Coagulation Inhibitor/analysis , Middle Aged , Necrosis , Recurrence , Urinary Tract/surgeryABSTRACT
The clinical, histological, immunophenotypic, and genotypic characteristics of two cases of cutaneous genuine histiocytic lymphoma are described. Both cases presented as cutaneous lesions. Both patients remain alive and free of disease at 26 and 10 months after the diagnosis and after having been treated with polychemotherapy. Neither peripheral blood nor bone marrow infiltration was detected in either case. Histological and immunophenotypic examination showed dense, diffuse dermic infiltrates of mononuclear cells with positive macrophage-associated markers (CD11c, CD68), and negative T- or B-cell-associated antigens. A germline configuration of both T-cell receptor and immunoglobulin genes was observed in gene rearrangement studies. Although most of the cases that have been diagnosed as histiocytic lymphoma or malignant histiocytosis in the past turned out to be B- or T-large-cell lymphomas, a small number of cases (two in our consecutive series of 350 cases) show characteristics of monocyte-macrophage tumors. We stress the importance of the CD68 marker in the diagnosis of true histiocytic lymphoma, suggest a therapeutic approach based on similarities with monocytic leukemia, and propose the use of the term monocytic sarcoma for this clinicopathological presentation.
Subject(s)
Lymphoma, Large B-Cell, Diffuse/pathology , Skin Neoplasms/pathology , Female , Gene Rearrangement , Humans , Immunophenotyping , Infant , Lymphoma, Large B-Cell, Diffuse/genetics , Lymphoma, Large B-Cell, Diffuse/immunology , Male , Middle Aged , Skin Neoplasms/genetics , Skin Neoplasms/immunologyABSTRACT
A case of cutaneous cytotoxic/suppressor T-cell (CD8+, CD4-) lymphoma is reported. The tumor was characterized by its rapid growth and no response to polychemotherapy. This unusual immunophenotype seems to be associated, in this and other cases reported previously, with a more aggressive course than the classic indolent course of cutaneous T-cell lymphoma.
Subject(s)
Antigens, Differentiation, T-Lymphocyte/analysis , CD4 Antigens/analysis , Lymphoma, T-Cell, Cutaneous/pathology , Skin Neoplasms/pathology , CD8 Antigens , Humans , Immunophenotyping , Lymphoma, T-Cell, Cutaneous/drug therapy , Lymphoma, T-Cell, Cutaneous/immunology , Male , Middle Aged , Skin Neoplasms/immunologySubject(s)
Arthritis, Reactive/pathology , Psoriasis/pathology , Adult , Diagnosis, Differential , Humans , Male , Skin/pathologySubject(s)
Carcinoma, Squamous Cell/radiotherapy , Lip Neoplasms/radiotherapy , Radium/therapeutic use , Adult , Aged , Female , Humans , Male , Methods , Middle Aged , Radiation ProtectionABSTRACT
Clear cell acanthoma (CCA) is a benign skin tumour, seldom multiple, perfectly individualized both clinically and histologically. The tumour is more usually mistaken for a seborrheic keratosis. There are large amounts of glycogen within the epidermal cells as can see upon staining with the PAS reaction. Melanogenesis is decreased. The enzymes characteristic of eccrine sweat glands are also decreased. The authors report a 67 years old psoriatic female with 15 C.C.A. They emphasize the treatment with topic 5FU particularly interesting in the multiple forms.
