Subject(s)
Humans , Female , Middle Aged , Daptomycin/adverse effects , Daptomycin/therapeutic use , Inappropriate ADH Syndrome/chemically induced , Inappropriate ADH Syndrome/complications , Inappropriate ADH Syndrome/therapy , Magnetic Resonance Imaging/methods , Inappropriate ADH Syndrome/drug therapy , Inappropriate ADH Syndrome/physiopathology , Osmolar ConcentrationABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Catatonia/etiology , Bipolar Disorder/complications , Diagnosis, DifferentialABSTRACT
No disponible
Subject(s)
Humans , Diabetes Mellitus/therapy , Diabetes Mellitus/complications , Insulin/administration & dosage , Clinical Protocols , Hospitalization/trendsABSTRACT
No disponible
Subject(s)
Adult , Female , Male , Middle Aged , Humans , Hypertension/diagnosis , Hypertension/therapy , Primary Prevention/standards , Primary Prevention/organization & administration , Antihypertensive Agents/therapeutic use , Hypertension/epidemiology , Hypertension/mortality , Primary Prevention/classification , Primary Prevention/statistics & numerical dataSubject(s)
Blood-Borne Pathogens , Malaria, Falciparum/transmission , Plasmodium falciparum , Transfusion Reaction , Aged , Animals , Female , HumansABSTRACT
We report two cases of hyperthyroidism clinically associated to edema, in which no usual causes for the latter were found. Correction of the hyperthyroidism state was associated with complete resolution of edema. The fact that one of the cases consisted of a farmacologically induced hyperthyroidism points to a direct effect of the thyroid hormone itself as the origin of this complication. The de novo occurrence of edema can be due to thyroid hyperfunction as the only underlying cause, the presence of other associated factors such as heart failure, hypoproteinemia or dermopathy not being necessary for its development.
Subject(s)
Edema/etiology , Hyperthyroidism/complications , Female , Humans , Middle AgedABSTRACT
This study is a double-blind, placebo-controlled, randomised clinical trial to evaluate the clinical and microbiological efficacy and safety of single dose ofloxacin for acute diarrhoea. Eligible patients were 16 years of age or older with a history of acute diarrhoea lasting no more than 48 h; 117 patients were randomised and 97.4% (114/117) were evaluable for efficacy. Of these, 58% were suspected to have ingested contaminated foods. Enteric pathogens were isolated in 61.5% of the patients, Salmonella enteritidis being reported in 87.5%. The patients received either a single 400 mg dose of ofloxacin, or placebo. The average duration of diarrhoea was 2.56 +/- 2.21 days in the ofloxacin group and 3.41 +/- 2.5 in the placebo group (P = 0.117). The average duration of fever was 0.63 +/- 0.95 days in the ofloxacin group and 1.05 +/- 0.96 in the placebo group (P = 0.02). Symptoms remained unchanged for more than 48 h in only 7% of the patients who received ofloxacin, compared with 12% in the placebo group (P = 0.485). Only 32% of patients in the ofloxacin group remained culture positive after 48 h compared with 59% in the placebo group (P = 0.0018). These represent a relative risk reduction (RRR) for stool clearance of 45.5% and absolute risk reduction (ARR) of 27% (95% Cl, 8-44.7), with a number of patients needed to treat (NNT) of 3.7 (95%, 2.7-11.3). After 15 days, 23.3% of patients in the ofloxacin group had a positive culture compared with 28.9% in the placebo (P = 0.63). This represents an RRR of 19%, an ARR of 5.6% and a NNT of 17.8. Adverse events in the ofloxacin group were observed in only one patient who reported headache and in one patient in the placebo group who developed a rash. In summary, empirical treatment with a single dose of ofloxacin in acute diarrhoea did not reduce the intensity or duration of symptoms (except possibly length of fever). It was notable however that stool cultures became negative for S. enteritidis by 48 h, with no relapse after 2 weeks of follow-up.
Subject(s)
Anti-Infective Agents/therapeutic use , Gastroenteritis/drug therapy , Ofloxacin/therapeutic use , Acute Disease , Adult , Anti-Infective Agents/administration & dosage , Anti-Infective Agents/adverse effects , Diarrhea/drug therapy , Diarrhea/microbiology , Double-Blind Method , Feces/microbiology , Female , Follow-Up Studies , Gastroenteritis/microbiology , Humans , Male , Ofloxacin/administration & dosage , Ofloxacin/adverse effects , Risk , Salmonella enteritidis/isolation & purification , Treatment OutcomeABSTRACT
Within the numerous complications of AIDS, we want to point out the appearance of inadequate ADH secretion syndrome (IADHSS) in 9 out of; patients, which constitutes a higher percentage than in the general population. In all cases IADHSS was associated to lung or central nervous system pathology. In one patient, IADHSS preceded the appearance Pneumocystis carinii pneumonitis. Therefore, if hyponatremia is founding AIDS patients, the existence of adrenal pathology or IADHSS should be suspected.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Inappropriate ADH Syndrome/complications , Adult , Female , Humans , Male , Middle AgedSubject(s)
Escherichia coli Infections/diagnosis , Escherichia coli/isolation & purification , Klebsiella Infections/diagnosis , Klebsiella pneumoniae/isolation & purification , Pneumonia/microbiology , Adult , Chronic Disease , Diagnosis, Differential , Humans , Male , Pneumonia/diagnosis , Tuberculosis, Pulmonary/diagnosisABSTRACT
The onset of a pneumonia by P. carinii in AIDS patients have force scientist to look for others therapies against this parasite. It is more necessary when the first line treatment which is cotrimoxazol produced secondary effects or not therapeutic effects. Pentamidine which is an agent usually used to treat leishmaniasis and trypanosomiasis, but it is an alternative for P. carinii infection. The problems are the frequent and severe secondary effects when administered by continuous infusions and less when it is inhaled. Between those effects are the changes in carbohydrate metabolism which are 9% of them. It is frequent observe hypoglycemia during infusion following by hyperglycemia in 5% of the cases which convert the patients in diabetic insulinodependent. A case of a patient who developed diabetes mellitus insulinodependent, 10 days after the end of pentamidine treatment, without previous episodes of hypoglycemia, is presented. The medical literature is reviewed.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Diabetes Mellitus, Type 1/chemically induced , Pentamidine/adverse effects , Adult , Humans , Male , Pentamidine/therapeutic use , Pneumonia, Pneumocystis/complications , Pneumonia, Pneumocystis/drug therapyABSTRACT
Spinal fluid from 53 HIV infected patients has been reviewed. A diagnosis was made exclusively from the spinal fluid exam in 15 cases while in 15 others it contributed to diagnosis together with other exams. The exam did not contribute any positive data in 23 cases. AIDS diagnosis was obtained in 11 patients by the spinal fluid exam. The most frequently occurring disease was infectious meningitis (10 cases) being 3 of them HIV aseptic meningitis. In our experience, a spinal fluid exam in HIV infected patients and fever of unknown origin did contribute useful data for the diagnosis of AIDS in a large number of cases.
Subject(s)
Acquired Immunodeficiency Syndrome/cerebrospinal fluid , Nervous System Diseases/cerebrospinal fluid , Acquired Immunodeficiency Syndrome/complications , Adult , Female , Humans , Male , Middle Aged , Nervous System Diseases/diagnosis , Nervous System Diseases/epidemiology , Nervous System Diseases/etiology , Spinal PunctureABSTRACT
28 cases of tuberculosis in patients infected with HIV, 22 of them having AIDS criteria (CDC 87), are presented. Tuberculosis was the first diagnosis criteria in 34% of the cases 68% were I.V.U., 25% homosexuals and 7% heterosexual. Half of the patients had disseminated tuberculosis and the other half had localised disease with a high frequency of pulmonary setting. The most frequent symptoms were fever and constitutional syndrome (92% and 91%). The patient's chest X-rays showed few cavitations and infiltrates and frequently had mediastinal and/or hilar (22%) lymphatic gland enlargement. The study of lymphocyte populations showed levels of CD4 lower than 400 in 79% of the cases. The response to treatment was favorable in 16 patients and only 3 died of tuberculosis.