[Infectious complications in 159 consecutive kidney transplant recipients]. / Complicaciones infecciosas en 159 receptores de trasplante renal consecutivos.

INTRODUCTION: The incidence of infections has decreased in kidney transplant (KT) recipients owing to advances in the surgical techniques and clinical management of this population. Nevertheless, these complications continue to occur and the causes seem to be changing, in part because of the prophylactic strategies used. METHOD: Prospective, observational study investigating infections occurring during the first 2 years post-transplantation in KT recipients who underwent surgery between July 2003 and December 2005 at Hospital Universitario Virgen del Rocío. Univariate and multivariate regression analysis was performed to determine risk factors associated with the development of infection. RESULTS: The incidence of infection was 1.11 episodes per patient over 510+/-234 days. The most common infections were urinary tract infection (UTI) (46.6%), cytomegalovirus (CMV) infection (22.7%), and surgical site infection (8%). The causes were bacterial (50.4%), viral (45.9%), and fungal (3.6%) agents. The most frequent pathogens were CMV (36%), Escherichia coli (28%), extended-spectrum beta-lactamase (ESBL)-producers (26%), and coagulase-negative staphylococci (6.3%). Seventy-nine percent of infection episodes occurred in the 4 months following KT. One recipient died 30 days after the infection episode. In the infection group, patient and graft survival at the end of follow-up was 98% and 89%, respectively. CONCLUSIONS: The most frequent syndromes were UTI, CMV infection and surgical site infection. The infections were mainly produced by bacteria, in particular gram-negative rods, and there was a high rate of ESBL E. coli.

Complicaciones infecciosas en 159 receptores de trasplante renal consecutivos / Infectious diseases in 159 consecutive kidney transplant recipients

Introducción gracias a los avances en la técnica quirúrgica y en el manejo clínico de los receptores de trasplante renal (TR), las infecciones han disminuido su incidencia. Sin embargo, continúan siendo frecuentes y cambiantes en función, en parte, de la profilaxis y la etiología local. Método estudio prospectivo y observacional de las infecciones en pacientes con TR realizado entre julio de 2003 y diciembre de 2005, durante los 2 primeros años postrasplante. Se ha realizado un análisis univariado y multivariado de los factores de riesgo asociados al desarrollo de infecciones. Resultados la incidencia de infección fue de 1,1 episodios/paciente (..) (AU)

Introduction: The incidence of infections has decreased in kidney transplant (KT) recipients owing to advances in the surgical techniques and clinical management of this population. Nevertheless, these complications continue to occur and the causes seem to be changing, in part because of the prophylactic strategies used. Method: Prospective, observational study investigating infections occurring during the first 2 years post-transplantation in KT recipients who underwent surgery between July 2003 and December 2005 at (..) (AU)