Subject(s)
Humans , Stroke/drug therapy , Hypertension , Antihypertensive Agents , Arterial PressureSubject(s)
Brain Ischemia , Hypertension , Stroke , Humans , Stroke/therapy , Hypertension/complications , Hypertension/therapy , Blood PressureABSTRACT
Se reseñan los medicamentos evaluados y con dictamen positivo por comisión de expertos de la Agencia Española de Medicamentos y Productos Sanitarios o de la Agencia Europea del Medicamento hechos públicos de enero a marzo de 2022, y considerados de mayor interés para el profesional sanitario. Se trata de opiniones técnicas positivas que son previas a la autorización y puesta en el mercado del medicamento. (AU)
Subject(s)
Humans , Hepatitis B virus , Insulin , DNAABSTRACT
Se reseñan los medicamentos evaluados y con dictamen positivo por comisión de expertos de la Agencia Española de MedicamentosSe reseñan los medicamentos evaluados y con dictamen positivo por comisión de expertos de la Agencia Española de Medicamentosy Productos Sanitarios o de la Agencia Europea del Medicamento hechos públicos de septiembre a diciembre de 2021, y considerados de mayor interés para el profesional sanitario. Se trata de opiniones técnicas positivas que son previas a la autorización y puestaen el mercado del medicamento. (AU)
The drugs assessed by the Spanish Agency for Medicines and Health Products or European Medicines Agency made public fromSeptember to December of 2021, and considered of interest to the healthcare professional, are reviewed. These are positive technicalreports prior to the authorization and placing on the market of the product. (AU)
Subject(s)
Humans , Cytokines , Intercellular Signaling Peptides and Proteins , Dermatitis, Atopic , Nausea , Pharmaceutical Preparations , TherapeuticsABSTRACT
Mixed acute rejection is a clinicopathological entity that is difficult to accurately diagnose, and so may be under-reported. Allografts are lost more often than in either humoral or cellular rejection. The diagnosis requires both histological and immunological studies on renal biopsy and blood specimens from the transplant recipient to provide the required rescue therapy to abolish the allogeneic response against the graft. We present a clinical case report of an active mixed acute rejection driven by a de novo donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T-cells in a patient with a kidney transplant. The patient was diagnosed, treated, and followed up as per the local institution's procedure with a full recovery of graft function. Our case emphasises the challenge of a mixed acute rejection and supports the need to improve the post-transplant outcome of recipients and their grafts.
Subject(s)
Graft Rejection , Isoantibodies , CD8-Positive T-Lymphocytes , HLA Antigens , Humans , KidneyABSTRACT
Infections by germs of Listeria genus can occur sporadically or in epidemic outbreaks and have different clinical presentations. Abdominal origin is very unusual among them, especially in no immunocompromised patients or without concurrent liver illness. We present a young healthy man who is lacking in underlying diseases, suffering from focal peritonitis caused by Listeria monocytogenes. The patient had to be operated on, requiring immediate colectomy and evacuation of a retroperitoneal abscess. The postoperative evolution was favorable under antibiotic treatment with amoxicillin and clavulanic acid during 3 weeks. The clinical-epidemiological and therapeutic aspects of listeriosis are analysed in the discussion, giving special attention to abdominal infective episodes.
Subject(s)
Abdominal Abscess/diagnosis , Listeriosis/diagnosis , Peritonitis/microbiology , Abdominal Abscess/surgery , Adult , Colectomy , Humans , Male , Peritonitis/surgeryABSTRACT
Incrusted cystitis is an infrequent process characterized by precipitation an incrustation of salts on the vesical mucosa. An alkanine urine is required to this precipitation. The urinary infection with urolithic activity microorganisms can also be a very important factor. We present a case of incrusted cystitis after using Mitomicine as vesical chemotherapy.
Subject(s)
Alkylating Agents/adverse effects , Cystitis/chemically induced , Mitomycin/adverse effects , Alkylating Agents/administration & dosage , Cystitis/pathology , Cystitis/surgery , Humans , Male , Middle Aged , Mitomycin/administration & dosage , Treatment Outcome , Urinary Bladder/drug effects , Urinary Bladder/pathology , Urinary Bladder/surgery , Urologic Surgical ProceduresABSTRACT
La cistitis incrustante o incrustada es un proceso frecuente que se caracteriza por la precipitación de sales en la mucosa vesical. La presencia de orinas alcalinas parece ser un factor fundamental para dicho depósito. Las infecciones urinarias por gérmenes urealíticos también parece ser un factor importante. Presentamos un caso de cistitis incrustante tras el uso de Mitomicina C como quimioterápico intravesical (AU)
Incrusted cystitis is an infrecuent process characterized by precipitation an incrustation of salts on the vesical mucosa. An alkanine urine is required to this precipitation. The urinary infection with urolithic activity microorganisms can also be a very important factor. We present a case of incrusted cystitis after using Mitomicine as vesical chemotherapy (AU)
Subject(s)
Male , Middle Aged , Humans , Mitomycin/adverse effects , Cystitis/chemically induced , Urinary Bladder Neoplasms/complications , Administration, Intravesical , Risk Factors , Neoplasm Recurrence, Local/drug therapyABSTRACT
CandidaDB is a database dedicated to the genome of the most prevalent systemic fungal pathogen of humans, Candida albicans. CandidaDB is based on an annotation of the Stanford Genome Technology Center C.albicans genome sequence data by the European Galar Fungail Consortium. CandidaDB Release 2.0 (June 2004) contains information pertaining to Assembly 19 of the genome of C.albicans strain SC5314. The current release contains 6244 annotated entries corresponding to 130 tRNA genes and 5917 protein-coding genes. For these, it provides tentative functional assignments along with numerous pre-run analyses that can assist the researcher in the evaluation of gene function for the purpose of specific or large-scale analysis. CandidaDB is based on GenoList, a generic relational data schema and a World Wide Web interface that has been adapted to the handling of eukaryotic genomes. The interface allows users to browse easily through genome data and retrieve information. CandidaDB also provides more elaborate tools, such as pattern searching, that are tightly connected to the overall browsing system. As the C.albicans genome is diploid and still incompletely assembled, CandidaDB provides tools to browse the genome by individual supercontigs and to examine information about allelic sequences obtained from complementary contigs. CandidaDB is accessible at http://genolist.pasteur.fr/CandidaDB.
Subject(s)
Candida albicans/genetics , Databases, Genetic , Genome, Fungal , Candida albicans/pathogenicity , Fungal Proteins/chemistry , Fungal Proteins/genetics , Fungal Proteins/physiology , Genomics , Internet , User-Computer InterfaceABSTRACT
INTRODUCTION: The risk of cerebral embolism following angioplasty-stent placement (AGP) is higher than that observed after a carotid endarterectomy (CE) using transcranial Doppler ultrasonography. Nevertheless, no studies have been conducted to compare the two revascularisation procedures with the latest neuroimaging techniques. AIMS: To analyse the presence and repercussion of acute cerebral ischemia detected by diffusion-weighted magnetic resonance imaging (DMR) following carotid revascularisation procedures. PATIENTS AND METHODS: Our prospective study included a sample of 20 consecutive patients with atherosclerotic stroke and symptomatic carotid stenosis > 70% according to NASCET criteria and treated by CE (n = 10) or AGP (n = 10). Patients were submitted to a DMR during the 48 hours prior to revascularisation and another within the 72 hours following the intervention in order to evaluate the existence of new acute cerebral ischemic lesions. Patients were explored by a neurologist before and after the intervention. RESULTS: DMR allowed new areas of cerebral ischemia to be detected in 10% of the CE and in 40% of the AGP patients. 50% of the post-AGP ischemic lesions were multiple and 10% of the lesions in each therapeutic group presented some clinical correlation in the form of transient neurological focal signs. No significant differences were observed with respect to the pattern of risk of complications between the two therapeutic groups and no factors associated to a higher risk of new ischemic lesions were detected by DMR in patients submitted to AGP. CONCLUSIONS: Carotid AGP is linked to a higher frequency of new ischemic lesions in the brain than in the case of CE. Nevertheless, these ischemic lesions detected by DMR are usually silent. Symptomatic complications were similar in the two procedures.
Subject(s)
Angioplasty, Balloon/adverse effects , Brain Ischemia/etiology , Endarterectomy, Carotid/adverse effects , Intracranial Embolism/etiology , Aged , Arteriosclerosis/pathology , Arteriosclerosis/surgery , Brain Ischemia/pathology , Carotid Stenosis/surgery , Diffusion Magnetic Resonance Imaging , Humans , Intracranial Embolism/pathology , Male , Middle Aged , Prospective Studies , Risk Factors , Stents/adverse effectsABSTRACT
Introducción. El riesgo de embolismo cerebral tras una angioplastia-endoprótesis (AGP) es superior al encontrado tras la endarterectomía carotídea (EC) mediante estudio Doppler transcraneal. Sin embargo, no existen estudios comparativos entre ambos procedimientos de revascularización con las técnicas recientes de neuroimagen. Objetivo. Analizar la presencia y repercusión de la isquemia cerebral aguda detectada mediante resonancia magnética por difusión (RMD) tras procedimientos de revascularización carotídea. Pacientes y métodos. Se incluyeron, de forma prospectiva, 20 pacientes consecutivos con ictus aterosclerótico y estenosis carotídea sintomática superior al 70 por ciento según los criterios NASCET y tratados con EC (n = 10) o AGP (n = 10). Se les practicó una RMD en las 48 horas previas a la revascularización y otra dentro de las 72 horas posteriores, para evaluar la existencia de nuevas lesiones isquémicas cerebrales agudas. El neurólogo exploró a los pacientes antes y después del procedimiento terapéutico. Resultados. Se detectaron nuevas áreas de isquemia cerebral con RMD en un 10 por ciento de las EC y en un 40 por ciento de las AGP. El 50 por ciento de las lesiones isquémicas tras la AGP fue múltiple. El 10 por ciento de las lesiones en cada grupo terapéutico presentó una correlación clínica en forma de focalidad neurológica transitoria. No se observaron diferencias significativas respecto al perfil de riesgo de complicaciones entre los grupos terapéuticos, ni se detectaron factores asociados a un mayor riesgo de lesiones isquémicas nuevas por RMD en los pacientes sometidos a AGP. Conclusión. La AGP carotídea se asocia a nuevas lesiones isquémicas cerebrales con más frecuencia que la EC; sin embargo, estas lesiones isquémicas detectadas mediante RMD son, habitualmente, silentes. Las complicaciones sintomáticas en ambos procedimientos fueron similares (AU)
Introduction. The risk of cerebral embolism following angioplasty-stent placement (AGP) is higher than that observed after a carotid endarterectomy (CE) using transcranial Doppler ultrasonography. Nevertheless, no studies have been conducted to compare the two revascularisation procedures with the latest neuroimaging techniques. Aims. To analyse the presence and repercussion of acute cerebral ischemia detected by diffusion-weighted magnetic resonance imaging (DMR) following carotid revascularisation procedures. Patients and methods. Our prospective study included a sample of 20 consecutive patients with atherosclerotic stroke and symptomatic carotid stenosis > 70% according to NASCET criteria and treated by CE (n = 10) or AGP (n = 10). Patients were submitted to a DMR during the 48 hours prior to revascularisation and another within the 72 hours following the intervention in order to evaluate the existence of new acute cerebral ischemic lesions. Patients were explored by a neurologist before and after the intervention. Results. DMR allowed new areas of cerebral ischemia to be detected in 10% of the CE and in 40% of the AGP patients. 50% of the post-AGP ischemic lesions were multiple and 10% of the lesions in each therapeutic group presented some clinical correlation in the form of transient neurological focal signs. No significant differences were observed with respect to the pattern of risk of complications between the two therapeutic groups and no factors associated to a higher risk of new ischemic lesions were detected by DMR in patients submitted to AGP. Conclusions. Carotid AGP is linked to a higher frequency of new ischemic lesions in the brain than in the case of CE. Nevertheless, these ischemic lesions detected by DMR are usually silent. Symptomatic complications were similar in the two procedures (AU)
Subject(s)
Aged , Male , Humans , Middle Aged , Intracranial Embolism , Angioplasty, Balloon , Arteriosclerosis , Stents , Risk Factors , Prospective Studies , Endarterectomy, Carotid , Carotid Stenosis , Diffusion Magnetic Resonance Imaging , Brain IschemiaABSTRACT
INTRODUCTION: Less than half of all subjects display a normal configuration of the Circle of Willis, according to anatomical studies. Variations of the middle cerebral artery (MCA) such as duplication or accessory MCA are infrequent but nevertheless have important clinical implications. We report the case of two patients with these variations of the MCA and their repercussions in the management of acute stroke are discussed. CASE REPORTS: Case 1: a 53 year old male with a 2 hour history of sensory motor syndrome; a transcranial Doppler (TCD) scan revealed asymmetrical speeds in the MCA. Spontaneous perforation of the MCA was suspected and we therefore decided to perform a magnetic resonance angiography scan before administering fibrinolytics. The magnetic resonance angiography scan showed an accessory MCA lying ipsilateral to the lesion. We interpreted the anomalies in blood flow detected in the TCD recording as being secondary to this anatomical variation and not due to reperfusion. Following the magnetic resonance angiography study, the possibility of fibrinolysis was ruled out. The patient recovered the neurological deficit in a matter of hours. Case 2: a 21 year old female with headaches and transient hemiparesis, who was diagnosed as suffering from migraine with aura. Later, following another stroke, it was shown that the previous clinical symptoms had been secondary to intracranial dissection with embolism in the lenticulostriate arteries and ischemic infarction in that territory. A magnetic resonance angiography scan showed duplication of the ipsilateral MCA. CONCLUSIONS: The double vascularisation of the hemisphere in cases of anatomical duplication can give rise to strokes with a better progression and prognosis, despite the occlusion of one of the MCA. The presence of anatomical variations of the MCA can lead to mistaken interpretations of the transcranial Doppler scan and may affect decision making as regards the therapy to be employed in patients with acute stroke.
Subject(s)
Brain Ischemia/diagnosis , Cerebral Infarction/diagnosis , Diagnostic Errors , Middle Cerebral Artery/anatomy & histology , Migraine with Aura/diagnosis , Acute Disease , Adult , Aortic Dissection/complications , Aortic Dissection/diagnosis , Blood Flow Velocity , Brain Ischemia/etiology , Cerebral Infarction/etiology , Cerebrovascular Circulation , Contraindications , Female , Fibrinolytic Agents , Genetic Variation , Headache/etiology , Humans , Intracranial Aneurysm/complications , Intracranial Aneurysm/diagnosis , Intracranial Embolism/diagnosis , Intracranial Embolism/etiology , Magnetic Resonance Angiography , Male , Middle Aged , Middle Cerebral Artery/embryology , Paresis/etiology , Prognosis , Ultrasonography, Doppler, TranscranialABSTRACT
Introducción. La conformación normal del polígono de Willis aparece en menos de la mitad de los sujetos, según estudios anatómicos. Las variantes de la arteria cerebral media (ACM) como la duplicidad o la ACM accesoria son infrecuentes, aunque con implicaciones clínicas importantes. Se presentan dos pacientes con estas variantes de la ACM y se discute su repercusión en el manejo del ictus agudo. Casos clínicos. Caso 1: varón de 53 años, con síndrome sensitivo motor de dos horas de evolución, cuya ecografía Doppler transcraneal (EDTC) mostró una asimetría de velocidades en la ACM. Ante la sospecha de reperfusión espontánea de la ACM, se decidió practicar una angiorresonancia antes de administrar fibrinolíticos. La angiorresonancia mostró una ACM accesoria ipsilateral a la lesión. Se interpretó que las anomalías de flujo detectadas en la EDTC eran secundarias a esta variante anatómica y no a reperfusión. Tras el estudio de angiorresonancia se desestimó la fibrinólisis. El paciente recuperó el déficit neurológico en el plazo de horas. Caso 2: mujer de 21 años, con cefalea y hemiparesia transitoria diagnosticada de migraña con aura. Posteriormente, a raíz de otro ictus, se demostró que el cuadro clínico previo había sido secundario a disección intracraneal con embolismo de las arterias lenticuloestriadas e infarto isquémico en dicho territorio. La angiorresonancia demostró una duplicidad de la ACM ipsilateral. Conclusiones. La doble vascularización hemisférica en casos de duplicidad anatómica puede ocasionar ictus de mejor evolución y pronóstico, a pesar de la oclusión de una de las ACM. La presencia de variantes anatómicas de la ACM puede dar lugar a interpretaciones erróneas del estudio Doppler transcraneal y afectar a la decisión terapéutica en pacientes con ictus agudo (AU)
Introduction. Less than half of all subjects display a normal configuration of the circle of Willis, according to anatomical studies. Variations of the middle cerebral artery (MCA) such as duplication or accessory MCA are infrequent but nevertheless have important clinical implications. We report the case of two patients with these variations of the MCA and their repercussions in the management of acute stroke are discussed. Case reports. Case 1: a 53-year-old male with a 2-hour history of sensory-motor syndrome; a transcranial Doppler (TCD) scan revealed asymmetrical speeds in the MCA. Spontaneous perforation of the MCA was suspected and we therefore decided to perform a magnetic resonance angiography scan before administering fibrinolytics. The magnetic resonance angiography scan showed an accessory MCA lying ipsilateral to the lesion. We interpreted the anomalies in blood flow detected in the TCD recording as being secondary to this anatomical variation and not due to reperfusion. Following the magnetic resonance angiography study, the possibility of fibrinolysis was ruled out. The patient recovered the neurological deficit in a matter of hours. Case 2: a 21-year-old female with headaches and transient hemiparesis, who was diagnosed as suffering from migraine with aura. Later, following another stroke, it was shown that the previous clinical symptoms had been secondary to intracranial dissection with embolism in the lenticulostriate arteries and ischemic infarction in that territory. A magnetic resonance angiography scan showed duplication of the ipsilateral MCA. Conclusions. The double vascularisation of the hemisphere in cases of anatomical duplication can give rise to strokes with a better progression and prognosis, despite the occlusion of one of the MCA. The presence of anatomical variations of the MCA can lead to mistaken interpretations of the TCD scan and may affect decision-making as regards the therapy to be employed in patients with acute stroke (AU)
Subject(s)
Humans , Middle Aged , Adult , Male , Female , Diagnostic Errors , Diagnostic Errors , Intracranial Embolism , Cerebral Infarction , Cerebrovascular Circulation , Ultrasonography, Doppler, Transcranial , Paresis , Middle Cerebral Artery , Magnetic Resonance Angiography , Intracranial Aneurysm , Prognosis , Headache , Genetic Variation , Blood Flow Velocity , Aortic Dissection , Acute Disease , Fibrinolytic Agents , Brain Ischemia , Migraine with Aura , Brain IschemiaSubject(s)
Lung Neoplasms/complications , Lymphoma, B-Cell/complications , Lymphoma, Non-Hodgkin/complications , Sjogren's Syndrome/complications , Diagnosis, Differential , Female , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis , Lung Neoplasms/diagnosis , Lymphoma, B-Cell/diagnosis , Lymphoma, Non-Hodgkin/diagnosis , Middle AgedABSTRACT
Cardiac rehabilitation programmes and secondary prevention programmes vary according to the type of cardiopathy, to the functional state and to the physical characteristics of the subject. On many occasions, they depend on the material resources and on the staff of the centre offering this type of therapeutic action. A summary of different ways of performing cardiac rehabilitation in our country is given.
Subject(s)
Myocardial Infarction/rehabilitation , Clinical Protocols , Exercise Therapy , Hospitalization , Humans , Myocardial Infarction/psychology , Patient Education as Topic , Self Care , SpainABSTRACT
A 12-year-old boy had a history of pain in the right knee for 2 months, mainly pain in extension. He could not recall any trauma to the knee. The radiograph suggested osteochondritis dissecans in the anterior spine. An arthroscopy was performed and a prominence in the tibial insertion of the anterior cruciate ligament in the anterointernal area was observed, and the fragment resected. The diagnosis of osteochondritis dissecans was confirmed by pathological study. As far as we are aware, this is the first case describing this new location.
