Subject(s)
Hemiplegia/complications , Leprosy, Lepromatous/diagnosis , Aged , Humans , Leprosy, Lepromatous/complications , MaleABSTRACT
A case of a 68-year-old male is presented, with a history of asymptomatic slight scaling, infiltrated patches with an atrophic central portion, of 3 months of evolution on the face and trunk. A chest X-ray showed an oat cell lung carcinoma, with the same evolution time as the cutaneous lesions. Several cutaneous biopsies showed typical sarcoid granulomas, with profuse giant cells. An immunohistochemical study showed B-cell-positive granulomas. The patient was treated with cytostatic drugs and prednisone, leading to cutaneous, radiological and clinical complete regression of the lesions. We think that this case corresponds to a tumor-related cutaneous sarcoid granuloma reaction.
Subject(s)
Carcinoma, Small Cell/pathology , Granuloma/pathology , Lung Neoplasms/pathology , Skin Diseases/pathology , Aged , B-Lymphocytes/pathology , Carcinoma, Small Cell/complications , Fatal Outcome , Giant Cells/pathology , Granuloma/complications , Humans , Immunohistochemistry , Lung Neoplasms/complications , Male , Paraneoplastic Syndromes/pathology , Remission Induction , Skin Diseases/complicationsABSTRACT
We report a 26-year-old housemaid whose partner was an intravenous drug abuser with undiagnosed pulmonary tuberculosis. The patient presented with a painless chin ulcer with an elevated irregular border and a firm, nontender submandibular adenopathy. The lesion had been present for 2 months and did not respond to antibiotic therapy. The tuberculin test was positive, and a biopsy and Löwenstein culture confirmed the diagnosis of cutaneous chancre. The patient was treated with rifampicin, isoniazid and pyrazinamide and, after 6 months of treatment, she developed scrofuloderma which had to be surgically removed. After 1 year of follow-up, the lesions had totally cleared.