Developmental impacts of heavy metals and undernutrition.

A recent Lancet series highlighted enormous loss to young children's developmental potential in developing countries, from exposure to sociocultural and health risks. The possibility that nutritional deficiencies might exacerbate the adverse impact of environmental exposures to developmental toxicants such as heavy metals and pesticides has not been explored. While both arsenic and manganese exposures have known neurotoxicity in adults, systematic investigation in young children has only recently begun. Five hundred and ninety 6- and 10-year-old Bangladeshi children participated in three overlapping studies. Well-water arsenic and manganese were measured from home wells; urine and blood samples were provided; and sociodemographic and household characteristics obtained. For new analyses, 'stunting' was defined as 2 or more standard deviations below the Centers for Disease Control and Prevention gender-specific height-for-age norms. Developmental assessments employed culturally adapted variants of the WISC-III (age 10) or WPPSI-III (age 6). In prior analyses, after adjusting for social factors, well-water arsenic and manganese were both significantly associated with poorer developmental scores at age 10; associations for water arsenic at 6 years were significant, but attenuated. Negative associations with metal exposures held up in newer analyses, and stunting was significantly associated with lower intellectual functioning in analyses considering either metal. There were no significant stunting-by-metal interactions. Developmental risks often co-occur. Millions in South Asia are exposed to naturally occurring arsenic and manganese through household wells. Stunting affects more than 25% of young children in developing countries. The combined neurocognitive loss from both risks, although rarely jointly studied, represents a substantial loss of global potential.

Setting priorities in global child health research investments: assessment of principles and practice.

This article reviews theoretical and practical approaches for setting priorities in global child health research investments. It also provides an overview of previous attempts to develop appropriate tools and methodologies to define priorities in health research investments. A brief review of the most important theoretical concepts that should govern priority setting processes is undertaken, showing how different perspectives, such as medical, economical, legal, ethical, social, political, rational, philosophical, stakeholder driven, and others will necessarily conflict each other in determining priorities. We specially address present research agenda in global child health today and how it relates to United Nation's (UN) Millennium Development Goal 4, which is to reduce child mortality by two-thirds between 1990 and 2015. The outcomes of these former approaches are evaluated and their benefits and shortcomings presented. The case for a new methodology for setting priorities in health research investments is presented, as proposed by Child Health and Nutrition Research Initiative, and a need for its implementation in global child health is outlined. A transdisciplinary approach is needed to address all the perspectives from which investments into health research can be seen as priorities. This prioritization requires a process that is transparent, systematic, and that would take into account many perspectives and build on advantages of previous approaches.

Child development: risk factors for adverse outcomes in developing countries.

Poverty and associated health, nutrition, and social factors prevent at least 200 million children in developing countries from attaining their developmental potential. We review the evidence linking compromised development with modifiable biological and psychosocial risks encountered by children from birth to 5 years of age. We identify four key risk factors where the need for intervention is urgent: stunting, inadequate cognitive stimulation, iodine deficiency, and iron deficiency anaemia. The evidence is also sufficient to warrant interventions for malaria, intrauterine growth restriction, maternal depression, exposure to violence, and exposure to heavy metals. We discuss the research needed to clarify the effect of other potential risk factors on child development. The prevalence of the risk factors and their effect on development and human potential are substantial. Furthermore, risks often occur together or cumulatively, with concomitant increased adverse effects on the development of the world's poorest children.

A randomized controlled trial of a home-visiting intervention on cognition and behavior in term low birth weight infants.

OBJECTIVES: To determine whether early psychosocial intervention with low birth weight term (LBW-T) infants improved cognition and behavior and to compare LBW-T with normal birth weight (NBW) infants. STUDY DESIGN: A randomized controlled trial was carried out in Kingston, Jamaica, with 140 LBW-T infants (weight<2500 g). The intervention comprised weekly home visits by paraprofessionals for the first 8 weeks of life aimed at improving maternal-child interaction. LBW-T and 94 matched NBW (weight 2500 to 4000 g) infants were recruited from the main maternity hospital. Main outcome measures were problem solving (2 means-end tests: cover and support) and 4 behavior ratings at 7 months. Analyses used were the t test for intervention effects and multiple regression to compare LBW and NBW infants. RESULTS: LBW-T intervened infants had higher scores than LBW-T control infants on the cover test (P<.05) and were more cooperative (P<.01) and happy (P<.05). LBW-T control infants had poorer scores on both the cover (P<.001) and support tests (P<.01), vocalized less (P<.02), and were less cooperative (P<.001), happy (P<.02), and active (P<.02) than NBW infants. LBW-T intervened infants had lower scores than NBW infants only on the support test (P<.05). CONCLUSIONS: Early low-cost intervention can improve cognition and behavior of LBW-T infants in developing countries.

Perceptions and experiences of violence among secondary school students in urban Jamaica.

OBJECTIVE: To obtain information on the perceptions and experiences of violence among secondary school students in Kingston, Jamaica, and its environs. METHODS: Data collection was carried out from September through December 1998. Two researchers administered questionnaires in 11 randomly selected secondary schools, to a total of 1 710 students who were in either grade 7 or grade 9 and who were aged 9-17 years old (mean of 13.2 years). Frequency distributions of the responses were compared by gender, age, grade level, socioeconomic status, and school type. RESULTS: Seventy-five percent of the students thought that someone who was reluctant to fight would be "picked on" more, 89% thought it generally wrong to hit other people, and 91% thought it wrong to insult other people. Eighty-four percent knew of students who carried knives or blades from such items as a scalpel or a utility knife to school, and 89% were worried about violence at school. Thirty-three percent had been victims of violence, and 60% had a family member who had been a victim of violence. Eighty-two percent thought that violent television shows could increase aggressive behavior. Factor analysis of selected responses was carried out, yielding five factors: neighborhood violence, school violence, perceptions of acceptable behaviors, level of concern about violence, and general experiences and perceptions of violence. The factors varied with gender, age, grade level, socioeconomic status, and school type. CONCLUSIONS: These results will help focus interventions aimed at reducing violence, provide a baseline for later comparisons of perceptions and experiences of violence, and offer a basis for comparing the experiences of young people in urban Jamaica with those of young persons elsewhere.

Perceptions and experiences of violence among secondary school students in urban Jamaica / Percepciones y experiencias en torno a la violencia en estudiantes de secundaria en la zona urbana de Jamaica

OBJECTIVE: To obtain information on the perceptions and experiences of violence among secondary school students in Kingston, Jamaica, and its environs. METHODS: Data collection was carried out from September through December 1998. Two researchers administered questionnaires in 11 randomly selected secondary schools, to a total of 1 710 students who were in either grade 7 or grade 9 and who were aged 9-17 years old (mean of 13.2 years). Frequency distributions of the responses were compared by gender, age, grade level, socioeconomic status, and school type. RESULTS: Seventy-five percent of the students thought that someone who was reluctant to fight would be "picked on" more, 89 percent thought it generally wrong to hit other people, and 91 percent thought it wrong to insult other people. Eighty-four percent knew of students who carried knives or blades from such items as a scalpel or a utility knife to school, and 89 percent were worried about violence at school. Thirty-three percent had been victims of violence, and 60 percent had a family member who had been a victim of violence. Eighty-two percent thought that violent television shows could increase aggressive behavior. Factor analysis of selected responses was carried out, yielding five factors: neighborhood violence, school violence, perceptions of acceptable behaviors, level of concern about violence, and general experiences and perceptions of violence. The factors varied with gender, age, grade level, socioeconomic status, and school type. CONCLUSIONS: These results will help focus interventions aimed at reducing violence, provide a baseline for later comparisons of perceptions and experiences of violence, and offer a basis for comparing the experiences of young people in urban Jamaica with those of young persons elsewhere.

Objetivo. Obtener información acerca de cuáles son las percepciones y experiencias en torno a la violencia de los estudiantes de secundaria en Kingston, Jamaica, y sus alrededores. Métodos. La recolección de datos tuvo lugar de septiembre a diciembre de 1998. En 11 escuelas secundarias elegidas aleatoriamente, dos investigadores administraron cuestionarios a un total de 1 710 estudiantes de séptimo o noveno grado entre las edades de 9 y 17 años (media de edad: 13,2 años). Las distribuciones de frecuencias de las contestaciones se compararon en función del sexo, la edad, el grado escolar, el estrato socioeconómico y el tipo de escuela del encuestado. Resultados. Setenta y cinco por ciento de los estudiantes opinaban que si uno no quiere pelear es más probable que sus pares lo acosen o se burlen; a 89% les parecía condenable pegarles a los demás, y 91% consideraban que es reprobable insultar a otros. Ochenta y cuatro por ciento de los encuestados conocían a estudiantes que llevaban cuchillos o navajas y 89% se sentían preocupados por la violencia en la escuela. Treinta y tres por ciento habían sido víctimas de actos violentos y 60% tenían algún pariente que también lo había sido. Ochenta y dos por ciento opinaban que los programas de televisión pueden empeorar la tendencia a comportarse de forma agresiva. Se efectuó un análisis factorial a partir de algunas respuestas y los factores identificados fueron cinco: la violencia en el vecindario, la violencia en la escuela, la percepción de que determinadas conductas son admisibles, el grado de preocupación por la violencia y las experiencias y percepciones generales que se tienen en torno a la violencia. Estos factores variaron en función del sexo, la edad, el grado escolar, el estrato socioeconómico y el tipo de escuela del encuestado. Conclusiones. Los presentes resultados ayudarán a focalizar adecuadamente las intervenciones encaminadas a reducir la violencia, proporcionarán la base para futuras comparaciones de las percepciones y experiencias de los jóvenes en torno a la violencia, y servirán para comparar las experiencias de la juventud en la zona urbana de Jamaica con las de la juventud en otros lugares

Caregiver knowledge, attitudes, and practices regarding childhood diarrhea and dehydration in Kingston, Jamaica.

OBJECTIVE: To study the knowledge, attitudes, and practices of caregivers in Kingston, Jamaica, regarding childhood diarrhea and dehydration in order to determine if limited caregiver knowledge about the prevention and treatment of diarrhea and dehydration puts children at increased risk of presenting at the hospital for these concerns. METHODS: The study was an observational case-control study conducted between February 1997 and May 1997 at Bustamante Hospital for Children in Kingston. Convenience sampling was used and data were collected by face-to-face interviews with two groups of caregivers of children under 5 years of age. One group (n = 117) presented with children with acute gastroenteritis, and the other group (n = 98) presented with acute concerns unrelated to gastroenteritis. While 197 of the 215 caregivers interviewed were the mother of a child, there were also 9 guardians, 5 fathers, and 4 grandmothers in the sample. RESULTS: The mean caregiver age, level of education, and socioeconomic status were similar for the two groups. The caregivers in the gastroenteritis group were more likely to present with younger children and to have less convenient access to running water or a refrigerator. Children of caregivers who had never heard of oral rehydration therapy were at increased risk of presenting with gastroenteritis and dehydration (odds ratio [OR], 4.6; 95% confidence interval [CI], 1.8-11.7), as were children of caregivers with low knowledge scores about the prevention and treatment of diarrhea and dehydration (OR, 3.7; 95% CI, 1.6-8.8). Another independent risk factor was a caregiver's poor sense of self-reliance in managing a child's diarrhea (OR, 2.3; 95% CI, 1.1-4.9). CONCLUSIONS: These findings highlight a need to enhance educational efforts that will empower caregivers to protect their children from diarrhea-associated morbidity and mortality.

Caregiver knowledge, attitudes, and practices regarding childhood diarrhea and dehydration in Kingston, Jamaica / Conocimientos, actitudes y prácticas de los cuidadores hacia la diarrea infantil y la deshidratación en Kingston, Jamaica

Objective. To study the knowledge, attitudes, and practices of caregivers in Kingston, Jamaica, regarding childhood diarrhea and dehydration in order to determine if limited caregiver knowledge about the prevention and treatment of diarrhea and dehydration puts children at increased risk of presenting at the hospital for these concerns. Methods. The study was an observational case-control study conducted between February 1997 and May 1997 at Bustamante Hospital for Children in Kingston. Convenience sampling was used and data were collected by face-to-face interviews with two groups of caregivers of children under 5 years of age. One group (n = 117) presented with children with acute gastroenteritis, and the other group (n = 98) presented with acute concerns unrelated to gastroenteritis. While 197 of the 215 caregivers interviewed were the mother of a child, there were also 9 guardians, 5 fathers, and 4 grandmothers in the sample. Results. The mean caregiver age, level of education, and socioeconomic status were similar for the two groups. The caregivers in the gastroenteritis group were more likely to present with younger children and to have less convenient access to running water or a refrigerator. Children of caregivers who had never heard of oral rehydration therapy were at increased risk of presenting with gastroenteritis and dehydration (odds ratio [OR], 4.6; 95% confidence interval [CI], 1.8­11.7), as were children of caregivers with low knowledge scores about the prevention and treatment of diarrhea and dehydration (OR, 3.7; 95% CI, 1.6­8.8). Another independent risk factor was a caregiver's poor sense of self-reliance in managing a child's diarrhea (OR, 2.3; 95% CI, 1.1­4.9). Conclusions. These findings highlight a need to enhance educational efforts that will empower caregivers to protect their children from diarrhea-associated morbidity and mortality

Objetivos. Estudiar los conocimientos, actitudes y prácticas de los cuidadores hacia la diarrea infantil y la deshidratación en Kingston, Jamaica, con el fin de determinar si sus escasos conocimientos sobre la prevención y el tratamiento de la diarrea y la deshidratación hacen que los niños corran mayor riesgo de hospitalización por estos problemas. Métodos. Se realizó un estudio observacional de casos y controles entre febrero y mayo de 1997 en el Hospital Infantil Bustamante de Kingston. Se usó una muestra de conveniencia de niños de menos de 5 años y los datos fueron recogidos mediante entrevistas personales con los cuidadores de los dos grupos de niños. Un grupo estaba formado por 117 niños con gastroenteritis aguda, y el otro por 98 niños con problemas agudos no relacionados con la gastroenteritis. De los 215 cuidadores entrevistados, 197 eran las madres, 9 eran tutores, 5 eran los padres y 4 eran las abuelas. Resultados. La media etaria de los cuidadores, su nivel educacional y su estatus socioeconómico eran similares en los dos grupos. Los cuidadores del grupo de niños con gastroenteritis tenían niños más pequeños y menos acceso al agua corriente y a frigoríficos. Los niños cuyos cuidadores nunca habían oído hablar de la rehidratación oral tenían mayor riesgo de presentar gastroenteritis y deshidratación [razón de posibilidades (odds ratio: OR): 4,6; intervalo de confianza del 95% (IC95): 1,8­11,7], al igual que los niños cuyos cuidadores tenían escasos conocimientos sobre la prevención y el tratamiento de la diarrea y la deshidratación (OR: 3,7; IC95: 1,6­8,8). Otro factor de riesgo independiente fue la poca confianza del cuidador en su propia capacidad para tratar la diarrea del niño (OR: 2,3; IC95: 1,1­4,9). Conclusiones. Estos resultados destacan la necesidad de incrementar los esfuerzos informativos que les permitan a los cuidadores proteger a los niños de la morbilidad y la mortalidad relacionadas con la diarrea.