Established and new rotavirus vaccines: a comprehensive review for healthcare professionals.

Robust scientific evidence related to two rotavirus (RV) vaccines available worldwide demonstrates their significant impact on RV disease burden. Improving RV vaccination coverage may result in better RV disease control. To make RV vaccination accessible to all eligible children worldwide and improve vaccine effectiveness in high-mortality settings, research into new RV vaccines continues. Although current and in-development RV vaccines differ in vaccine design, their common goal is the reduction of RV disease risk in children <5 years old for whom disease burden is the most significant. Given the range of RV vaccines available, informed decision-making is essential regarding the choice of vaccine for immunization. This review aims to describe the landscape of current and new RV vaccines, providing context for the assessment of their similarities and differences. As data for new vaccines are limited, future investigations will be required to evaluate their performance/added value in a real-world setting.

PLAIN LANGUAGE SUMMARYThe diseaseRotaviruses are a leading cause of acute diarrhea, also called gastroenterities, among young children. They can lead to servere dehydration, hospitilization, and even death.Several vaccines against rotavirus disease have been developed. Their design is based on:weakened human rotavirus that mimic natural infection without causing disease, such as Rotarix, Rotavin-M1, Rotavac and RV3-BB (not yet marketed)non-infective animal viruses such as RotaTeq, Rotasiil or LLR.new concepts, such as inactivated vaccinesWhat is new?We reviewed the current, recently launched and soon-to-be-launched rotavirus vaccines and found that:Rotarix and RotaTeq have been used globally for more than a decade with demonstrated impact and favourable safety profileLimited data on the impact and safety profile are available to date for:Rotavin-M1 and LLR vaccines, locally marketed in Vietnam and China, respectivelyRotavac and Rotasiil, licensed in indiaNew vaccine concepts have been mainly investigated animal models with encouraging resultsWhat is the impact?Despite their different designs, the current rotavirus vaccines demonstrate effectiveness in protecting against rotairus gastroenterits.Data for most recent vacciness are currently limited, for which additional data are needed to demonstrate how they will perform on a larger scale, their added value in a real setting and ther safety profile.

Model Victims of Hate: Victim Blaming in the Context of Islamophobic Hate Crime.

Prior research has explored victim blaming in the context of hate, often depicting hate crime victims as relatively passive recipients of harassment and violence. In reality, victims often do engage with their perpetrators, and the present research explored the effect that victim behavior might have on observer reactions to Islamophobic hate crimes. Participants completed a measure of Islamophobia and read a scenario in which a White man verbally harassed a victim in the park before physically assaulting him. We manipulated both the victim's identity (White or South Asian Muslim) and the victim's response to the perpetrator's verbal harassment (the victim either ignored the offensive comments, verbally reacted to them, or became physically confrontational). When the victim was portrayed as passive and nonresponding, the South Asian Muslim victim attracted lower victim blame, higher perpetrator blame, and increased certainty that the offense was a hate crime. As the victim's behavior became more aggressive, victim blaming increased and perpetrator blaming decreased, but only for the South Asian Muslim victim. It appeared that observers scrutinized the behavior of the South Asian Muslim victim in a way they did not for the White victim, such that sympathy toward the Muslim hate crime victim was tied to his "good behavior." We propose that observers hold expectations of the model hate crime victim, one who is a racialized, religious, or sexual minority who accepts harassment passively and with good behavior; deviation from this script results in a loss of sympathy and an increase in victim blaming. Finally, those higher in Islamophobia displayed reduced perpetrator blame, guilt, and sentences but greater victim blame when the crime targeted a South Asian Muslim as opposed to White victim.

Current misuses of multiple regression for investigating bivariate hypotheses: an example from the organizational domain.

By definition, multiple regression (MR) considers more than one predictor variable, and each variable's beta will depend on both its correlation with the criterion and its correlation with the other predictor(s). Despite ad nauseam coverage of this characteristic in organizational psychology and statistical texts, researchers' applications of MR in bivariate hypothesis testing has been the subject of recent and renewed interest. Accordingly, we conducted a targeted survey of the literature by coding articles, covering a five-year span from two top-tier organizational journals, that employed MR for testing bivariate relations. The results suggest that MR coefficients, rather than correlation coefficients, were most common for testing hypotheses of bivariate relations, yet supporting theoretical rationales were rarely offered. Regarding the potential impact on scientific advancement, in almost half of the articles reviewed (44 %), at least one conclusion of each study (i.e., that the hypothesis was or was not supported) would have been different, depending on the author's use of correlation or beta to test the bivariate hypothesis. It follows that inappropriate decisions to interpret the correlation versus the beta will affect the accumulation of consistent and replicable scientific evidence. We conclude with recommendations for improving bivariate hypothesis testing.

Composition and adult activity of salt-marsh mosquitoes attracted to 1-octen-3-ol, carbon dioxide, and light in Topsail Island, North Carolina.

By monitoring weekly for 3 months with Centers for Disease Control (CDC) light traps baited with carbon dioxide (CO2) and light, 12 species of mosquitoes were collected from salt-marsh areas in Topsail Island, North Carolina: Aedes vexans, Anopheles atropos, An. bradleyi, An. crucians, An. punctipennis, Culex pipiens, Cx. restrans, Cx. salinarius, Ochlerotatus sollicitans, Oc. taeniorhynchus, Oc. infirmatus, and Uranotaenia sapphirina. The hourly activities of common salt-marsh mosquitoes, namely Oc. sollicitans, Oc. taeniorhynchus, An. atropos, An. bradleyi, and Cx. salinarius, were observed from 1700 to 0800 h by using a collection bottle rotator trap baited with 1-octen-3-ol (octenol), CO2, and light. The mosquitoes exhibited different peaks of adult activity, with a significantly greater number of mosquitoes collected from 0600 to 0800 h than from 1700 to 1900 h.