Comparison of machine learning algorithms for the classification of spinal cord tumor.

Spinal cord Tumor has been characterized as a heterogeneous disease consisting of many different subtypes. The early diagnosis and prognosis of a cancer type have become a necessity in cancer research, as it can facilitate the subsequent clinical management of patients. The importance of classifying cancer patients into Bening or malignant has led many re- search teams, from the biomedical and the bioinformatics field, to study the application of machine learning (ML) methods. Therefore, these techniques have been utilized as an aim to model the progression and treatment of cancerous conditions. In addition, the ability of ML tools to detect key features from complex datasets reveals their importance. A variety of these techniques, Logistic regression, Support Vector Machines (SVMs), Decision Trees (DTs), Random forest classifier(RFs) have been widely applied in cancer research for the development of predictive models, resulting in effective and accurate decision making. Even though it is evident that the use of ML methods can improve our understanding of cancer progression, an appropriate level of validation is needed in order for these methods to be considered in the everyday clinical practice. In this work, we have discussed a predictive model based on various supervised ML techniques.

A case of tetralogy of Fallot associated with left anterior descending coronary artery to pulmonary artery fistula.

Presence of coronary to pulmonary artery fistula is generally a feature of pulmonary atresia with ventricular septal defect. We present a rare case of left anterior descending coronary artery to pulmonary artery fistula in a patient of tetralogy of Fallot.

Primary ciliary dyskinesia--an underdiagnosed entity.

Primary ciliary dyskinesia (PCD) also known as immotile cilia syndrome is a genetic disorder characterised by chronic infections of the upper and lower respiratory tracts, male infertility and situs inversus totalis. Authors are presenting clinical details of a patient who was operated upon for recalcitrant rhinosinusitis. Investigations carried to find out the predisposing factors for such sinusitis, resulted in diagnosing the patient a case of PCD, a rare but well known cause of recalcitrant sinusitis.

Fatal Burkholderia cepacia early prosthetic valve endocarditis: a very rare case and a review of the literature.

A 58-year-old woman who underwent mitral valve replacement and tricuspid valve repair developed severe acute systemic illness four weeks after surgery. Serial blood cultures grew Burkholderia cepacia at four to five days after incubation. Transthoracic echocardiography had confirmed a diagnosis of prosthetic valve endocarditis. The patient did not respond to empirical or culture-sensitive antibiotic therapy of endocarditis. Trimethoprim-sulfamethoxazole (TMP-SMX) therapy was only commenced at three weeks after the start of fever because of delayed presentation. Every effort should be made to identify this organism in the laboratory. When clinically indicated, early presumptive antibiotic therapy with TMP-SMX should be started.