ABSTRACT
Work remains to be done to understand the origins of ocular aberrations. We analyze lens aberrations of several species with Y-suture branches (bovine, ovine, and porcine) and their relationship with suture distribution. Aberrations are measured in vitro with a point diffraction interferometer in 10 different eyes of each species. The minimum number of Zernike polynomials minimizing the root mean square error of the wavefront is estimated by processing the interferograms. Through this we find significant amounts of astigmatism, coma, spherical aberration, and trefoil in the lenses of the three species. Moreover, we observe a high degree of correlation between the orientation of the lens sutures and the axis of nonrotationally symmetric aberrations. Our results point to lens sutures as the histological origin of the most significant lens aberrations: astigmatism, coma, and trefoil, but we are unable to find a major suture governing all the axes.
Subject(s)
Lens, Crystalline/pathology , Animals , Astigmatism/pathology , Astigmatism/veterinary , Cattle , Cattle Diseases/pathology , Interferometry/instrumentation , Interferometry/methods , Lens, Crystalline/growth & development , Optical Phenomena , Refraction, Ocular , Refractive Errors/pathology , Refractive Errors/veterinary , Sheep , Sheep Diseases/pathology , Sheep, Domestic , Species Specificity , Sus scrofa , Swine , Swine Diseases/pathologyABSTRACT
No disponible
Subject(s)
Male , Middle Aged , Humans , Erythema/diagnosis , Erythema/therapy , Cachexia/diagnosis , Biopsy , Tomography, Emission-Computed/methods , Carcinoma/diagnosis , Colonoscopy/methods , Immunohistochemistry/methods , Diagnosis, Differential , Combined Modality Therapy , Umbilicus/pathology , Cachexia/complications , Carcinoma/complications , Erythema/complications , Umbilicus/surgery , Umbilicus , Hyperuricemia/complications , Abdominal Neoplasms/diagnosis , Abdominal Neoplasms/therapyABSTRACT
Merkel cell carcinoma (MCC) is an infrequent neuroendocrine tumor of the skin with a high potential for local recurrence, lymphatic dissemination and distant dissemination. We present a case of MCC in a male patient with chronic lymphocytic leukemia (CLL). The immunosuppression induced by the leukemia or by the chemotherapy could play a pathogenic role in the association of these diseases. Positron emission tomography (PET) was a useful staging technique in this patient, and made the differential diagnosis of the lymph node involvement from MMC and CLL possible.
Subject(s)
Carcinoma, Merkel Cell/pathology , Leukemia, Lymphocytic, Chronic, B-Cell , Neoplasms, Second Primary/pathology , Skin Neoplasms/pathology , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Merkel Cell/diagnostic imaging , Carcinoma, Merkel Cell/radiotherapy , Carcinoma, Merkel Cell/secondary , Carcinoma, Merkel Cell/surgery , Cyclophosphamide/adverse effects , Cyclophosphamide/therapeutic use , Diagnosis, Differential , Humans , Immunocompromised Host , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell/immunology , Lymph Node Excision , Lymphatic Metastasis/radiotherapy , Male , Middle Aged , Neoplasms, Second Primary/diagnostic imaging , Neoplasms, Second Primary/radiotherapy , Neoplasms, Second Primary/surgery , Positron-Emission Tomography , Prednisone/adverse effects , Prednisone/therapeutic use , Radiotherapy, Adjuvant , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/surgery , Vincristine/adverse effects , Vincristine/therapeutic useABSTRACT
El carcinoma de células de Merkel (CCM) es un tumor neuroendocrino cutáneo infrecuente con un elevado potencial de recurrencias locales, diseminación linfática y diseminación a distancia. Presentamos un caso de CCM en un paciente con leucemia linfática crónica (LLC). La inmunosupresión inducida por la leucemia o por la quimioterapia podría desempeñar un papel patogénico en la asociación de estas enfermedades. La tomografía por emisión de positrones (PET) es una técnica de estadiaje útil en este paciente, y permite el diagnóstico diferencial de la afectación ganglionar por CCM y LLC
Merkel cell carcinoma (MCC) is an infrequent neuroendocrine tumor of the skin with a high potential for local recurrence, lymphatic dissemination and distant dissemination. We present a case of MCC in a male patient with chronic lymphocytic leukemia (CLL). The immunosuppression induced by the leukemia or by the chemotherapy could play a pathogenic role in the association of these diseases. Positron emission tomography (PET) was a useful staging technique in this patient, and made the differential diagnosis of the lymph node involvement from MMC and CLL possible
