ABSTRACT
Merkel cell carcinoma (MCC) is an infrequent neuroendocrine tumor of the skin with a high potential for local recurrence, lymphatic dissemination and distant dissemination. We present a case of MCC in a male patient with chronic lymphocytic leukemia (CLL). The immunosuppression induced by the leukemia or by the chemotherapy could play a pathogenic role in the association of these diseases. Positron emission tomography (PET) was a useful staging technique in this patient, and made the differential diagnosis of the lymph node involvement from MMC and CLL possible.
Subject(s)
Carcinoma, Merkel Cell/pathology , Leukemia, Lymphocytic, Chronic, B-Cell , Neoplasms, Second Primary/pathology , Skin Neoplasms/pathology , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Merkel Cell/diagnostic imaging , Carcinoma, Merkel Cell/radiotherapy , Carcinoma, Merkel Cell/secondary , Carcinoma, Merkel Cell/surgery , Cyclophosphamide/adverse effects , Cyclophosphamide/therapeutic use , Diagnosis, Differential , Humans , Immunocompromised Host , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell/immunology , Lymph Node Excision , Lymphatic Metastasis/radiotherapy , Male , Middle Aged , Neoplasms, Second Primary/diagnostic imaging , Neoplasms, Second Primary/radiotherapy , Neoplasms, Second Primary/surgery , Positron-Emission Tomography , Prednisone/adverse effects , Prednisone/therapeutic use , Radiotherapy, Adjuvant , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/surgery , Vincristine/adverse effects , Vincristine/therapeutic useABSTRACT
El carcinoma de células de Merkel (CCM) es un tumor neuroendocrino cutáneo infrecuente con un elevado potencial de recurrencias locales, diseminación linfática y diseminación a distancia. Presentamos un caso de CCM en un paciente con leucemia linfática crónica (LLC). La inmunosupresión inducida por la leucemia o por la quimioterapia podría desempeñar un papel patogénico en la asociación de estas enfermedades. La tomografía por emisión de positrones (PET) es una técnica de estadiaje útil en este paciente, y permite el diagnóstico diferencial de la afectación ganglionar por CCM y LLC
Merkel cell carcinoma (MCC) is an infrequent neuroendocrine tumor of the skin with a high potential for local recurrence, lymphatic dissemination and distant dissemination. We present a case of MCC in a male patient with chronic lymphocytic leukemia (CLL). The immunosuppression induced by the leukemia or by the chemotherapy could play a pathogenic role in the association of these diseases. Positron emission tomography (PET) was a useful staging technique in this patient, and made the differential diagnosis of the lymph node involvement from MMC and CLL possible
