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1.
Childs Nerv Syst ; 33(11): 1969-1976, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28770391

ABSTRACT

PURPOSE: An intensive therapeutic strategy for metastatic medulloblastoma was launched in 1998 in our Institution. The aim of this study was to examine the long-term quality of life (QoL) in survivor patients at least 3 years after the end of the treatment. METHODS: Patients were asked to complete self-administered QoL questionnaires. An index of physical impairment (IPI) was scored (range 0-100; the lower the score the better) based on clinical objective observations. Patients were divided into two groups (lower IPI group, and higher IPI group) and descriptively compared accordingly. RESULTS: The study was completed by 25/33 eligible patients. Despite patients with a higher IPI reported worse perceived health condition, they had better emotional and psychological scores than those with a lower IPI in all QoL questionnaires. CONCLUSION: In our sample, patients with more severe objective and perceived physical impairments reported a better psychosocial QoL, possibly because the greater attention paid to them by society and family contributes to a better adjustment in long-term survivors. On this base, it should be recommended that all survivors receive a strong support as the most impaired patients.


Subject(s)
Cerebellar Neoplasms/radiotherapy , Medulloblastoma/radiotherapy , Radiotherapy/adverse effects , Survivors/psychology , Adolescent , Child , Dose Fractionation, Radiation , Female , Humans , Male , Quality of Life , Radiotherapy/methods , Surveys and Questionnaires
2.
J Heart Lung Transplant ; 16(9): 969-73, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9322149

ABSTRACT

In a patient with Becker type muscular dystrophy, the development of cardiomyopathy may require heart transplantation, and during both the perioperative period and later it is useful to determine whether myocardial cell damage is occurring; however, the measurement of serum levels of creatine kinase (CK), MB isoenzyme, is not useful because that isoenzyme is released by the dystrophic skeletal muscle, as well as damaged myocardium. Because cardiac troponin I (cTn I) seems to be quite specific for myocardial cells, we reasoned that measurement of serum levels of this protein could distinguish between myocardial damage and skeletal muscle disease in this patient during and after transplantation. During the immediate postoperative period, the time course of the release of total CK (tCK), CK MB mass, myoglobin, and cTn I were different, yielding a peak within 4 hours for CK MB, 24 hours for myoglobin and 36 hours for tCK and cTn I. During the first postoperative year, the patient displayed a release of tCK, CK MB, and myoglobin; cTn I was constantly lower than the reference value for cardiac myocyte necrosis, suggesting the presence of a continuous muscular damage without any myocardial involvement and an accurate specificity of cTn I to differentiate between myocardial and muscular cell damage in patients with neuromuscular disorders.


Subject(s)
Cardiomyopathy, Dilated/surgery , Heart Transplantation/physiology , Muscular Dystrophies/surgery , Postoperative Complications/blood , Troponin I/blood , Adolescent , Biomarkers/blood , Cardiomyopathy, Dilated/blood , Cardiomyopathy, Dilated/diagnosis , Hemodynamics/physiology , Humans , Male , Muscular Dystrophies/blood , Muscular Dystrophies/diagnosis , Postoperative Complications/diagnosis , Prognosis , Recurrence
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