1.
Psychoneuroendocrinology
; 31(4): 543-7, 2006 May.
Article
in English
| MEDLINE
| ID: mdl-16356651
ABSTRACT
We tested and compared the use of two adjunctive hormonal agents, tamoxifen and medroxyprogesterone acetate (MPA), for the treatment of acute mania or hypomania. A total of 13 women with acute Bipolar Affective Disorder in the manic or hypomanic phase were recruited from a clinical population to participate in this 28-day, three-arm, double blind, placebo-controlled study. The women who received tamoxifen exhibited significant improvement in symptoms of mania from baseline to final assessment compared with the placebo group. The MPA group improved more than the placebo group. Further exploration of tamoxifen as a useful adjunct in the treatment of acute manic symptoms in women with Bipolar Affective Disorder is warranted.
Subject(s)
Antimanic Agents/therapeutic use , Bipolar Disorder/drug therapy , Medroxyprogesterone/therapeutic use , Tamoxifen/therapeutic use , Acute Disease , Adult , Analysis of Variance , Bipolar Disorder/blood , Double-Blind Method , Estradiol/blood , Estrogen Antagonists/therapeutic use , Female , Humans , Middle Aged , Pilot Projects , Progesterone Congeners/therapeutic use , Psychiatric Status Rating Scales , Statistics, Nonparametric , Treatment Outcome
2.
Aust Fam Physician
; 34(11): 990, 2005 Nov.
Article
in English
| MEDLINE
| ID: mdl-16299641