Comparative effectiveness of accommodating and weight resistance training modes.

Six men and six women trained the elbow flexors of both arms 3 d.wk-1 for 20 wk. In each training session, one arm did 3-5 sets of 10 maximal concentric actions on an accommodating resistance device (ARD), the other arm 3-5 sets of 8-12 coupled eccentric/concentric actions (repetitions) to volitional failure (8-12 RM) on a weight resistance device (WRD). The average "intensity" (force of concentric actions) was approximately 1.25 times greater in ARD training, the average "volume" (number of actions x force of actions) 1.6 times greater in WRD training, and the time required to complete a training session the same for each. Both types of training produced significant increases in a single maximum weight lift (1 RM on the WRD), in the peak force of a single maximal concentric action measured on the ARD and an isovelocity dynamometer, and in biceps, brachialis, and total elbow flexor cross-sectional area (CSA). Biceps Type I and II fiber area did not change significantly. WRD training produced greater increases than ARD training in the 1 RM test on the WRD and in brachialis CSA. The data indicate that both of these common training regimens effectively increase strength and muscle mass, but the weight training regimen may be more effective for increasing muscle mass.

Response to resistance training in young women and men.

Six women and 6 men trained the elbow flexors 3 days per week for 20 wks, one arm performing in each session 3-5 sets of 10 maximal concentric actions on an accommodating resistance device, the other arm 3-5 sets of 8-12 coupled eccentric/concentric actions on a weight training device. With results collapsed across the two training modes, the women made significantly (p < 0.05) greater relative increases than men in strength measured on the weight (116 vs. 46%) and accommodating (99 vs. 46%) resistance devices, and greater absolute (3.5 vs. -1.3 N.m) and relative (13.7 vs. -3.2%) increases in strength measured on an isokinetic dynamometer. Absolute (cm2) and relative (%) biceps, brachialis, and total elbow flexor cross-sectional area (from CT scans) increased significantly; however, the women's vs. men's respective relative and absolute increases did not differ significantly: biceps (13 vs. 7%, 0.9 vs. 1.0 cm2), brachialis (53 vs. 31%, 2.1 vs. 2.3 cm2), and total (26 vs. 15%, 3.1 vs. 3.3 cm2) flexor area. Biceps type I and II fiber area, and the II/I area ratio did not increase significantly. The data indicate that in response to the same short-term training program, muscle size increases similarly in women and men but women make greater relative increases in strength.

Operation Everest II: neuromuscular performance under conditions of extreme simulated altitude.

The force output of the ankle dorsiflexors was studied during a 40-day simulated ascent of Mt. Everest in a hypobaric chamber; both electrically activated and maximal voluntary contractions (MVCs) were employed. The purpose of this study was to establish whether, under conditions of progressive chronic hypoxia, there was a decrease in muscle force output and/or increased fatigability. We also attempted to identify the main site of any failure, i.e., central nervous system, neuromuscular junction, or muscle fiber. Muscle twitch torque (Pt), tetanic torque (Po), MVC torque, and evoked muscle compound action potential (M wave) were monitored during 205-s exercise periods in five subjects at three simulated altitudes (760, 335, and 282 Torr). All three types of torque measurement were well preserved at the three altitudes. In some subjects, the responses to stimuli interpolated during repeated MVCs provided evidence of "central" fatigue at altitude. In addition, the rate of fatigue during 20-Hz electrical stimulation was greater (P less than 0.01) at altitude and there was increased fatigability of the twitch (P less than 0.025); however, the M wave amplitude was maintained. We conclude that central motor drive becomes more precarious at altitude and is associated with increased muscle fatigue at low excitation frequencies; the latter is the result, in part, of chronic hypoxia and occurs in the muscle fiber interior because no impairment in neuromuscular transmission could be demonstrated.

Prolongation of twitch potentiating mechanism throughout muscle fatigue and recovery.

Measurements have been made of twitch amplitudes in human ankle dorsiflexor muscles during and following fatiguing electrical stimulation. In six subjects, studied with the arterial circulation occluded, the twitch was observed to undergo an early potentiation (mean, 99 +/- 50%) followed by complete disappearance. A second, smaller phase of potentiation (mean, 25 +/- 30%) occurred during recovery and gave way to prolonged depression of the twitch. A comparison of these results with those obtained with an intact circulation suggested that the four phases in the behavior of the twitch were the net result of two processes, potentiation and fatigue, with different time courses. Provided they are timed appropriately, observations of twitch amplitude can provide useful information concerning the development of, and recovery from, muscle fatigue.

The effects of strength training in patients with selected neuromuscular disorders.

Five subjects with spinal muscular atrophy, limb-girdle or facioscapulohumeral muscular dystrophy, were studied. Measurements pre- and post-training included: maximum isometric, dynamic and isokinetic strength, in single-arm curl and double-leg press exercises; contractile properties of the elbow flexors; computerized tomography of the upper arms and thighs; muscle biopsies from the biceps brachii muscle of each arm in three subjects. Dynamic weight training was performed 3 times per week for 9 wk; exercises comprised unilateral arm curls (the contralateral arm acted as a control), and bilateral leg press. Strength increases in the trained arm were between 19 and 34%, and from -14 to +25% in the control arm; leg strength increased from 11 to 50%. Moreover, the pretraining maximum load could be lifted from 3 to 48 times in the trained limbs, and from 1 to 13 times in an untrained limb before fatigue. Contractile properties of the elbow flexors were unchanged with training, but pre-intervention, three subjects demonstrated incomplete motor unit activation. Most of the gains in strength were apparently due to a neural adaptation, rather than muscle hypertrophy. The tomograms and biopsy samples were inadequate to determine muscle, or muscle fiber areas with confidence; they did indicate however, no additional overt muscle structural damage. Strength training may be a potentially useful therapeutic option in the management of selected neuromuscular disorders.

Relationship between numbers and frequencies of stimuli in human muscle fatigue.

The effect of stimulus frequency on the rate of muscle fatigue has been studied on dorsiflexor muscles of the human ankle. It was found that significantly fewer stimuli were required to abolish twitch and tetanic torque when the stimuli were delivered at 15 Hz rather than 30 Hz. At both stimulus frequencies twitch torque disappeared before tetanic torque. The difference in numbers of stimuli required for fatigue was not due to impaired excitation of muscle fibers at either of the two frequencies. At both stimulating frequencies, twitch fatigue appeared to be due to a defect in excitation-contraction coupling and/or the contractile machinery.

Reduced voluntary electromyographic activity after fatiguing stimulation of human muscle.

1. After ischaemic ankle dorsiflexor muscles had been fatigued by repetitive stimulation of the peroneal nerve at 15 Hz, there was a reduction in voluntary EMG activity which persisted as long as the arterial cuff remained inflated. 2. The reduction in voluntary EMG activity could not have been due to loss of excitability at the neuromuscular junctions or muscle fibre membranes since the M-waves (muscle compound action potentials) evoked by peroneal nerve stimulation were well maintained. 3. The preceding observations were consistent with the view that the reduction in EMG activity was due to reflex inhibition of motoneurones by afferents from the fatigued muscle. 4. The absence of responses to stimuli interpolated among the voluntary activity indicated that any motor units which could not be recruited in the fatigued muscle were no longer capable of generating tension.

Heart rate response to facial immersion and apnea in quadriplegia.

Profound bradycardia is a common complication in the early posttraumatic period following cervical spinal cord damage. It is thought to be due to temporary inactivity of the sympathetic nervous system after separation from supraspinal control, coupled with unopposed parasympathetic dominance because of vagus nerve sparing. Hypoxia, underventilation, and tracheal suctioning appear to intensify the bradycardia. This study examined the effect of vagal stimulation using facial immersion and apnea on heart rate in patients with quadriplegia. Ten patients with quadriplegia (eight males and two females, mean age 25, age range 16-37) and ten healthy controls (eight males and two females, mean age 25, age range 15-37) underwent facial immersion during ECG monitoring. The patients with quadriplegia were studied at a mean of 9.4 months after injury (range, 4-26 months); cord level of injury ranged from C5 to C8; seven of the ten had had heart rates of less than 50 beats/min in the early period after injury and five of the ten had received treatment for this. No change in heart rate was seen in the quadriplegic group during facial immersion (delta = 1.5 +/- 2.7 beats/min, mean +/- SE), but a significant drop in heart rate was seen in the control group (delta = -12.2 +/- 3.7 beats/min, mean +/- SE; p less than 0.01). No significant decreases were seen in either group during apnea alone. Patients with chronic quadriplegia appear to have less sensitivity than controls to the vagal-stimulating maneuver of facial immersion and apnea.