ABSTRACT
Head and neck squamous cell carcinoma (HNSCC) originates in the squamous cell lining the mucosal surfaces of the head and neck region, including the oral cavity, nasopharynx, tonsils, oropharynx, larynx, and hypopharynx. The heterogeneity, anatomical, and functional characteristics of the patient make the HNSCC a complex and difficult-to-treat disease, leading to a poor survival rate and a decreased quality of life due to the loss of important physiologic functions and aggressive surgical injury. Alteration of driver-oncogenic and tumor-suppressing lncRNAs has recently been recently in HNSCC to obtain possible biomarkers for diagnostic, prognostic, and therapeutic approaches. This review provides current knowledge about the implication of lncRNAs in drug resistance mechanisms in HNSCC. Chemotherapy resistance is a major therapeutic challenge in HNSCC in which lncRNAs are implicated. Lately, it has been shown that lncRNAs involved in autophagy induced by chemotherapy and epithelial-mesenchymal transition (EMT) can act as mechanisms of resistance to anticancer drugs. Conversely, lncRNAs involved in mesenchymal-epithelial transition (MET) are related to chemosensitivity and inhibition of invasiveness of drug-resistant cells. In this regard, long non-coding RNAs (lncRNAs) play a pivotal role in both processes and are important for cancer detection, progression, diagnosis, therapy response, and prognostic values. As the involvement of more lncRNAs is elucidated in chemoresistance mechanisms, an improvement in diagnostic and prognostic tools could promote an advance in targeted and specific therapies in precision oncology.
ABSTRACT
RESUMEN: En la práctica forense un dato de gran importancia es la edad cronológica de los pacientes, este puede obtenerse de múltiples formas, algunas son complejas, costosas y tardadas, el cálculo de la edad dental (ED) por vía radiográfica es sencillo y de bajo costo, ha mostrado ser concordante con la edad cronológica (EC), presentando variaciones por sexo y raza. El objetivo de este estudio es establecer la concordancia de la ED y la EC en población mexicana. Este es un estudio transversal, observacional en el que un residente estandarizado evaluó 88 Ortopantomografías (44 femeninos y 44 masculinos) de manera cegada respecto a la EC, del archivo de la clínica de Ortodoncia de la Facultad de Odontología de la Universidad Autónoma de Sinaloa, con edades desde los 3 a los 16 años. Existe una diferencia en meses de 3,36 entre los valores ED y EC en el total de la población (p=0,384) con una concordancia de 94 % entre los valores. Al analizarlos por sexo los masculinos muestran una diferencia de 5,16 (P=0,785) con una concordancia de 96 % y los femeninos de 7,32 (P=0,095) con una concordancia de 92 %. La ED según Demirjian es un método confiable para estimar la EC en esta población.
ABSTRACT: In forensic practice knowledge of chronological age (CA) is an important factor, and it can be estimated by several methods. Some are complex, expensive and time consuming. Dental Age (DA) estimation by radiographic methods is easy and inexpensive, it has shown to be consistent with chronological age (CA), with variations according to sex and race. The objective of this study was to estimate the concordance between DA and CA in Mexicans. This is a cross sectional, observational study, in which a standardized dental resident reviewed 88 Orthopantomographies (44 female, 44 male), blinded to CA, of the Orthodontics School Files of the Universidad Autónoma de Sinaloa, the population was 3 to 16 years of age. The main difference in months between DA and CA was 3.36 (p=0.384) and 94 % of concordance, the analysis by sex for males showed a main difference of 5.16 (P=0.785) and 96 % concordance; for females it showed 7.32 (P=0.095) and concordance of 92 %. In conclusion the DA according to Demirjian is a reliable method to estimate CA in these patients.
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Tooth/growth & development , Age Determination by Teeth/methods , Dentition , Tooth/diagnostic imaging , Radiography, Panoramic , Cross-Sectional Studies , Reproducibility of Results , Models, Statistical , Age Factors , MexicoABSTRACT
OBJECTIVE: To study bolus-size of different foods in 8- to 10-year-olds and appraise if 1.7-2 g of condensation silicone (Optosil®) is an adequate size to study masticatory performance in children. METHODS: Bolus-size of seven foods (carrot, almonds, sausage, banana, cookie, gummy bears, raisins) (placed in random order on a scale) was studied in 20 children, aged 8-10 years. Children picked up the amount they would normally take of each, and chewed and swallowed it (three repetitions/each). STATISTICAL ANALYSIS: Descriptive; comparisons with ad hoc tests. RESULTS: There are no gender differences in bolus-size. Bolus-size was constant but different for each food.There is no pattern of bolus-size depending on hardness. Bolus-size was largest for banana; smallest foralmonds. Bite-size for carrot (food most similar to Optosil®) is 2.6 times larger than the size used for Optosil®. DISCUSSION: The results support using this bolus-size of the artificial-test-food to further study masticatory function in children.
