ABSTRACT
Haemostatic abnormalities are a common phenomenon in patients with thyroid diseases. On one hand the condition of hyperthyroidism is associated with an increased risk of thrombotic events, on the other in severe hypothyroidism can be found a haemorrhagic tendency, as opposed to the subclinical hypothyroidism seems to correlate with increased thrombotic risk. The prospective, single center, observational MITH study (Mantua Investigation on Thyroid and Haemostasis), whose results are presented, aims to evaluate coagulation parameters in patients with thyroid disease, to establish the prevalence of haemostatic abnormalities in various conditions, to analyse the implications and clinical response to therapy established.
Subject(s)
Hemostatic Disorders/epidemiology , Hyperthyroidism/complications , Hypothyroidism/complications , Thrombosis/epidemiology , Female , Hemorrhage/epidemiology , Hemorrhage/etiology , Hemostatic Disorders/etiology , Humans , Male , Middle Aged , Prevalence , Prospective Studies , Risk , Severity of Illness Index , Thrombosis/etiologyABSTRACT
The Gram-negative bacterium Helicobacter pylori has a well-demonstrated role in several gastroduodenal diseases, including peptic ulcer disease, chronic active gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric adenocarcinoma. In addition, more recently, several studies have focused on the possible causal role of H. pylori in various extragastric disorders, such as cardiovascular, respiratory, neurological, skin, and autoimmune conditions. The current status of the research on the pathogenesis, clinical and therapeutic aspects of H. pylori-associated idiopathic thrombocytopenic purpura in adults and children will be addressed in this narrative review.
Subject(s)
Helicobacter Infections/blood , Helicobacter Infections/microbiology , Helicobacter pylori/isolation & purification , Purpura, Thrombocytopenic, Idiopathic/microbiology , Adult , Child , Disease Eradication , Helicobacter Infections/therapy , Humans , Purpura, Thrombocytopenic, Idiopathic/therapyABSTRACT
The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors including hormones. A variety of endocrine disorders have been reported to be associated with coagulation abnormalities, ranging from mild laboratory changes to clinically relevant thrombotic or bleeding manifestations. In this review, we summarize the current knowledge on the main abnormalities of the coagulation and fibrinolytic systems associated with thyroid dysfunctions. Overall, although mostly based on uncontrolled studies, data in the literature suggest that patients with hyperthyroidism or subclinical hypothyroidism have a hypercoagulative state, whereas patients with overt hypothyroidism have a bleeding tendency.
