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3.
Mutat Res ; 537(2): 141-9, 2003 Jun 06.
Article in English | MEDLINE | ID: mdl-12787819

ABSTRACT

In some cities of the autonomous community of Extremadura (south-west of Spain), levels of simazine from 10 to 30 ppm were detected in tap water. To analyse the possible effect of this herbicide, two biomarkers, sister chromatid exchanges (SCE) and micronuclei (MN), were used in peripheral blood lymphocytes from males exposed to simazine through drinking water. SCE and MN analysis failed to detect any statistically significant increase in the people exposed to simazine when compared with the controls. With respect to high frequency cells (HFC), a statistically significant difference was detected between exposed and control groups.


Subject(s)
Environmental Exposure/adverse effects , Herbicides/adverse effects , Lymphocytes/drug effects , Micronuclei, Chromosome-Defective/drug effects , Simazine/adverse effects , Sister Chromatid Exchange/drug effects , Water Pollutants, Chemical/adverse effects , Administration, Oral , Adult , Drinking , Herbicides/administration & dosage , Humans , Male , Micronuclei, Chromosome-Defective/genetics , Micronucleus Tests , Middle Aged , Simazine/administration & dosage , Simazine/analysis , Sister Chromatid Exchange/genetics , Water Pollutants, Chemical/administration & dosage , Water Pollutants, Chemical/analysis , Water Supply/analysis
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