Effect of Antioxidant Supplementation on Markers of Oxidative Stress and Muscle Damage after Strength Exercise: A Systematic Review.

BACKGROUND: The purpose of this systematic review was to determine the effect of antioxidant consumption on markers of oxidative stress and muscle damage after performing a muscle strength exercise. METHODS: The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statements were followed. Four databases were used: Scopus, PubMed, WOS and SportDiscus. Methodological quality was assessed using the PEDro scale. RESULTS: A total of 1709 articles were retrieved and following duplicate removal and application of exclusion criteria seven articles were reviewed. Supplementation with pomegranate juice alleviates oxidative stress, taurine reduces muscle damage, melatonin protects the skeletal muscles, blueberries decrease oxidation and oats mitigate muscle damage. CONCLUSIONS: Acute administration of antioxidants immediately before or during an exercise session can have beneficial effects, such as delay of fatigue and a reduction in the recovery period. Administration of antioxidant susbtances may reduce muscle damage and oxidative stress markers.

Oropharyngeal dysphagia, an underestimated disorder in pediatrics.

Oropharyngeal dysphagia is a rather frequent clinical entity in patients with neurological problems that can lead to serious complications such as aspiration pneumonia and other disorders like dehydration or malnutrition due to feeding difficulties. It should be suspected in children with splitting of food intake or prolonged feeding, coughing or choking during feeding, continuous drooling or repeated respiratory symptoms. For the diagnosis, apart from the examination of swallowing, additional tests can be run like the water-swallowing test, the viscosity-volume test (which determines what kind of texture and how much volume the patient is able to tolerate), a fiberoptic endoscopy of swallowing or a videofluoroscopic swallow study, which is the gold standard for the study of swallowing disorders.It requires a multidisciplinary approach to guarantee an adequate intake of fluids and nutrients with minimal risk of aspiration. If these two conditions cannot be met, a gastrostomy feeding may be necessary.

Disfagia orofaríngea, un trastorno infravalorado en pediatría / Oropharyngeal dysphagia, an underestimated disorder in pediatrics

La disfagia orofaríngea es una entidad clínica bastante frecuente en pacientes con problemas neurológicos, que puede conllevar complicaciones graves como las neumonías aspirativas y otras alteraciones como deshidratación o desnutrición por dificultades para la alimentación. Debe sospecharse en niños con fraccionamiento de la toma o ingestas prolongadas, tos o atragantamientos asociados a la alimentación, babeo continuo o sintomatología respiratoria de repetición. Para su diagnóstico, además de la exploración de la deglución, pueden hacerse pruebas complementarias como la prueba de deglución del agua, la de viscosidad-volumen (determina qué tipo de textura y cuánto volumen puede tolerar el paciente), la fibroendoscopia de la deglución y la videofluoroscopia (el gold estándar para el estudio de los trastornos de la deglución). Requiere un abordaje multidisciplinar para asegurar un adecuado aporte oral de líquido y nutrientes, con mínimo riesgo de aspiración. Si estas dos condiciones no son posibles puede ser necesaria la alimentación por gastrostomía

Oropharyngeal dysphagia is a rather frequent clinical entity in patients with neurological problems that can lead to serious complications such as aspiration pneumonia and other disorders like dehydration or malnutrition due to feeding difficulties. It should be suspected in children with splitting of food intake or prolonged feeding, coughing or choking during feeding, continuous drooling or repeated respiratory symptoms. For the diagnosis, apart from the examination of swallowing, additional tests can be run like the water-swallowing test, the viscosity-volume test (which determines what kind of texture and how much volume the patient is able to tolerate), a fiberoptic endoscopy of swallowing or a videofluoroscopic swallow study, which is the gold standard for the study of swallowing disorders. It requires a multidisciplinary approach to guarantee an adequate intake of fluids and nutrients with minimal risk of aspiration. If these two conditions cannot be met, a gastrostomy feeding may be necessary

Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study.

BACKGROUND AND AIMS: The aim of the study was to evaluate the effect of melatonin administration on sleep and behavioral disorders in the elderly and the facilitation of the discontinuation of regular hypnotic drugs. METHODS: This was a prospective, randomized, double-blind, placebo-controlled, crossover trial in a community-living population. Participants were 22 older adults (7 men, 15 women over 65) with a history of sleep disorder complaints. Fourteen of these subjects were receiving hypnotic drug therapy. Participants received 2 months of melatonin (5 mg/day) and 2 months of placebo. Sleep disorders were evaluated with the Northside Hospital Sleep Medicine Institute (NHSMI) test, discarding secondary insomnia and evaluating sleep quality. Behavioral disorders were evaluated with the Yesavage Geriatric Depression Scale (GDS) and Goldberg Anxiety Scale (GAS). Patients discontinuing hypnotic drugs were also recorded. RESULTS: Melatonin treatment for two months significantly improved sleep quality scores measured by the NHSMI test (1.78+/-0.40) when compared with both basal (3.72+/-0.45; p=0.001) and placebo (3.44+/-0.56; p=0.025) groups. Depression measured by GDS and anxiety measured by GAS also improved significantly after melatonin administration (p=0.043 and p=0.009, respectively). Nine out of 14 subjects receiving hypnotic drugs were able to discontinue this treatment during melatonin but not placebo administration; one discontinued hypnotic drugs during both melatonin and placebo administration, and four were unable to discontinue hypnotic therapy. CONCLUSIONS: The results of this study suggest that melatonin administration significantly improves sleep and behavioral disorders in the elderly and facilitates discontinuation of therapy with conventional hypnotic drugs.

Characterization of odor-active volatiles in champa (Campomanesia lineatifolia R. and P.).

Volatile extracts from pulp, peels, leaves, and seeds of champa (Campomanesia lineatifolia R. and P.) were obtained by continuous liquid-liquid extraction with pentane/dichloromethane (1:1), and their chemical composition was determined by using HRGC and HRGC-MS. Differences between C. lineatifolia volatile extracts with regard to the identified compounds are presented; however, in all of them the beta-triketones were detected as major constituents (between 50 and 60% of total extract). An odor profile description of volatiles isolated in all of the extracts was obtained by HRGC-O. These analyses showed that beta-triketones contributed to the fruity, floral, and green odor notes in the flavor of fruit. Application of AEDA to pulp volatile extract revealed 2,5-dimethyl-4-methoxy-3(2H)-furanone, 2-phenylethanol, and 2,3-dihydro-5-hydroxy-6,8,8-trimethyl-2-phenyl-4H-1-benzopyran-4,7(8H)-dione (champanone C) to have the highest flavor dilution factors. In a similar way, (E)-cinnamyl alcohol, 2,5-dimethyl-4-methoxy-3(2H)-furanone, and 2,3-dihydro-5-hydroxy-6,8,8-trimethyl-2-phenyl-4H-1-benzopyran-4,7(8H)-dione (champanone C) were identified as key odorant compounds in the fruit peel volatile extract. This is the first time that the volatile composition in champa is reported and also the sensory odor importance of beta-triketones.

Champanones, yellow pigments from the seeds of champa (Campomanesia lineatifolia).

Chemical investigation of the methanol extract of the seeds of Campomanesia lineatifolia Ruiz and Pav. (Myrtaceae) led to the isolation of two new beta-triketone type compounds, named champanones A (1) and B (2), together with the known 2,3-dihydro-5-hydroxy-6,8,8-trimethyl-2-phenyl-4H-1-benzopyran-4,7(8H)-dione (champanone C) (3). The structures of 1 and 2 were determined to be 2,2,4,4-tetramethyl-6-(1-oxo-3-phenylprop-2-enyl) cyclohexane-1,3,5-trione (occurs as an enol form) and 2,2,4-trimethyl-6-(1-oxo-3-phenylprop-2-enyl)cyclohexane-1,3,5-trione (occurs as an enol form), respectively, by means of spectroscopic analysis. The three compounds showed mild antimicrobial activity.

Cyclobutane dimers from the Colombian medicinal plant Achyrocline bogotensis.

Five cyclobutane dimers, achyrodimers A-E (1-5), along with 11 known compounds were isolated from the methanol extract of the Colombian medicinal plant Achyrocline bogotensis. Their structures were elucidated by spectroscopy. Several of these compounds were screened for cytokine-inducing activity in human peripheral blood mononuclear cells.

Chemical constituents from the Colombian medicinal plant Maytenus laevis.

The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds. The structures of the new and known compounds were elucidated on the basis of spectroscopic evidence. Several of these compounds were screened for cytokine-inducing activity on human PBMCs to investigate antitumor effects, and canophyllol (12) demonstrated the most effective induction of the cytokines.

Chemical constituents from the colombian medicinal plant Niphogeton ternata.

Two coumarins and one polyacetylene, 5-0-(3-chloro-2-hydroxy-3-methylbutyl)-8-methoxypsoralen (1), 2',3'-dihydro-jatamansin (2), and 10-chloro-1-heptadecene-4,6-diyne-3,8,9-triol (3), along with 15 known compounds (4-18), were isolated from the methanol extract of Niphogeton ternata. Their structures were elucidated by spectroscopy.