NFL during acute spinal cord lesions in MS: a hurdle for the detection of inflammatory activity.

INTRODUCTION: Levels of neuro-filament light chain (NFL) correlate with clinical and radiological activity in multiple sclerosis (MS) and have been used as a surrogate biomarker of axonal destruction related to inflammatory activity. The main objective of this work is to explore the specific contribution of acute inflammation within the spinal cord to the elevation of NFL levels. PATIENTS AND METHODS: MS patients with a baseline study of NFL at diagnosis of the disease and a brain and spinal cord MRI scan were selected. Patients were classified according to the presence, number and location of gadolinium enhancing lesion (GEL) and the relationship between NFL levels and both brain and spinal cord GEL were explored. RESULTS: Seventy-seven patients were selected. NFL levels were significantly higher in patients with only one GEL restricted to the brain than those without GEL (1702 pg/ml vs 722.7 pg/mL, p = 0.03) and correlated with number. However, no differences were seen among patients with GEL limited to the spinal cord and those without GEL (735.2 pg/ml vs 722.7 pg/mL). CONCLUSION: Our study reaffirms the value of NFL levels in monitoring asymptomatic inflammatory activity in the brain measured by GEL. However, NFL concentration is not as useful when only inflammatory activity occurs in the spinal cord.

Protective effects of melatonin on changes occurring in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

BACKGROUND: Melatonin has been related to the pathophysiology of multiple sclerosis (MS), and its anti-inflammatory and immunomodulatory properties have been proved in numerous neurodegenerative diseases. This study aimed to find out whether a melatonin supplement in MS is able to act as a benefit to its clinical status, i.e. oxidative stress, inflammation and indirect biomarkers of bacterial dysbiosis, lipopolysaccharide (LPS) and LPS-binding protein (LBP), verifying its therapeutic potential and its possible clinical use in patients with MS. METHODS: The animal MS model, experimental autoimmune encephalomyelitis (EAE), was employed whereby 25 male Dark Agouti rats (5 animals per group) were divided into: a control group (not manipulated); a control+vehicle group; a control+melatonin group; an EAE group; an EAE+melatonin group. Melatonin was administered daily for 51 days, at a dose of 1 mg/kg body weight/i.p., once a day, five days a week. RESULTS: The results from the administration of melatonin demonstrated an improvement in clinical status, a diminution in oxidative stress and inflammation, as well as in bacterial dysbiosis. CONCLUSION: Melatonin could play an effective role against MS, either alone or as a therapy combined with traditional agents.

Optimization of the magnetic field homogeneity of circular and conical coil pairs.

The magnetic field generated by a pair of coaxial circular loops is analyzed in order to find the optimum separation between the loops for each value of a prescribed homogeneity. For the maximum heterogeneities considered here, 0.1%, 1%, and 10%, the optimum loop spacing is obtained following a graphical procedure so that the length of the homogeneous field region along the axis is the longest possible. This study is extended to regions near the axis and to the entire region surrounding the center, calculating the loop separation that produces the largest homogeneous volume. The field homogeneity of a pair of "Helmholtz" coaxial conical coils is also investigated to obtain the optimum spacing between the conical coils; the volumes calculated with the desired homogeneity are compared with those obtained with a single pair of optimum coaxial loops. A new arrangement is hereby proposed based on double conical coils with optimum separation between the coils and optimum aperture of the cones. Some of the proposed arrangements are carried out in the laboratory where the experimental results are in good agreement with the theoretical predictions.

Treatment with alemtuzumab or rituximab after fingolimod withdrawal in relapsing-remitting multiple sclerosis is effective and safe.

BACKGROUND: It has been described that treating relapsing-remitting multiple sclerosis (RRMS) patients with alemtuzumab following fingolimod could be less effective due to the different dynamics of lymphocyte repopulation. Effectiveness and safety of alemtuzumab compared to rituximab after fingolimod withdrawal were analyzed. PATIENTS AND METHODS: A follow-up of a cohort of RRMS patients treated with alemtuzumab or rituximab after fingolimod withdrawal was accomplished. Effectiveness, measured by the percentage of patients with no evidence of disease activity (NEDA), and the presence of side effects (SE) were registered. RESULTS: Fifty-five patients, 28 with alemtuzumab and 27 with rituximab, were analyzed. No differences in the washout period or in the baseline lymphocytes counts were observed. After a mean follow-up period of 28.8 months, the annualized relapsing rate was significantly reduced in the alemtuzumab group from 1.29 to 0.004 (p < 0.001) and in the rituximab group from 1.24 to 0.02 (p < 0.001), without differences. A significant reduction of the median EDSS from 2.8 to 2.0 in the alemtuzumab group and from 3.5 to 2.5 (p < 0.01) in the rituximab group was observed, without differences. Eighty-two per cent (n = 28) of patients in alemtuzumab group and 69.2% (n = 26) in rituximab group achieved NEDA criteria, without differences (p = 0.3). Symptoms related to the infusion were the most frequent SE in both groups. No serious SE were registered. CONCLUSION: Treating RRMS patients with alemtuzumab or rituximab after fingolimod withdrawal is effective and safe, without significant differences between both groups in our series.

Efficacy and safety of rituximab in relapsing and progressive multiple sclerosis: a hospital-based study.

INTRODUCTION: Rituximab is considered as a potential therapeutic option in relapsing-remitting (RRMS) and progressive forms (PMS) of multiple sclerosis (MS). OBJECTIVE: To investigate the effectiveness and safety of rituximab in MS. PATIENTS AND METHODS: Observational study of effectiveness (clinical and radiological) and safety of rituximab in RRMS and PMS. RESULTS: A total of 90 rituximab-treated patients were collected: 31 RRMS and 59 PMS All patients had an active disease despite standard treatment. The annualized relapse rate (ARR) the year before rituximab was 0.86, 53.3% of patients had gadolinium enhanced lesion, and mean Expanded Disability Status Scale (EDSS) had increased from 4.2 to 4.9. During treatment, the ARR was reduced an 88.4% (p < 0.001). A significant decrease of EDSS to 4.6 was observed (p = 0.01) after 1 year of treatment, which remained stable during the second year in both groups. There was no evidence of disease activity in 70% of total sample, 74.2% of RRMS, and 67% of the PMS patients. Infusion-related symptoms were the most prevalent side effect (18.8%) and most were mild. Three thrombotic events were detected. CONCLUSION: Rituximab could be an effective and safe treatment in aggressive RRMS. Some selected PMS patients could also benefit from this treatment.

Magnetic field homogeneity of a conical coaxial coil pair.

An analytical study of the magnetic field created by a double-conical conducting sheet is presented. The analysis is based on the expansion of the magnetic field in terms of Legendre polynomials. It is demonstrated analytically that the angle of the conical surface that produces a nearly homogeneous magnetic field coincides with that of a pair of loops that fulfills the Helmholtz condition. From the results obtained, we propose an electric circuit formed by pairs of isolated conducting loops tightly wound around a pair of conical surfaces, calculating numerically the magnetic field produced by this system and its heterogeneity. An experimental setup of the proposed circuit was constructed and its magnetic field was measured. The results were compared with those obtained by numerical calculation, finding a good agreement. The numerical results demonstrate a significant improvement in homogeneity in the field of the proposed pair of conical coils compared with that achieved with a simple pair of Helmholtz loops or with a double solenoid. Moreover, a new design of a double pair of conical coils based on Braunbek's four loops is also proposed to achieve greater homogeneity. Regarding homogeneity, the rating of the analyzed configurations from best to worst is as follows: (1) double pair of conical coils, (2) pair of conical coils, (3) Braunbek's four loops, (4) Helmholtz pair, and (5) solenoid pair.

[Natalizumab and reduction of carbonylated proteins in patients with multiple sclerosis]. / Natalizumab y reduccion de los niveles de proteinas carboniladas en pacientes con esclerosis multiple.

INTRODUCTION: The sensitivity of the central nervous system to oxidative damage and its relationship with inflammatory response are well known. Recent studies have shown that oxidative stress is present in the establishment and development of multiple sclerosis (MS). One of the most recent treatments in this process is natalizumab, a monoclonal antibody. AIM: To evaluate whether the therapeutic effect of natalizumab is associated with the severity of the disease and the oxidative damage. PATIENTS AND METHODS: Researchers recruited twenty patients with relapsing-remitting MS (RRMS) undergoing therapy with natalizumab and distributed, according to the Expanded Disability Status Scale (EDSS), in two groups: RRMS-1 (EDSS < 5) and RRMS-2 (EDSS ≥ 5). Blood samples were taken for an oxidative profile study. RESULTS: Data showed a decrease in carbonylated proteins following treatment with natalizumab. The reduction in oxidative damage rated as protein oxidation is significant between the previous (baseline) situation of the patient and after 14 months' treatment. The most significant decrease coincided with the patients with the highest levels of severity in the process. Although it has not been possible to establish a correlation, the statistical significance is higher for patients in the RRMS-2 group treated with natalizumab. The antioxidant systems, on the other hand, did not display any statistically significant changes. CONCLUSIONS: Natalizumab brings about a reduction in carbonylated protein levels.

Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: effects on neurotrophic factors and neuronal density.

There is evidence to suggest that the neuroprotective effect of exposure of extremely low-frequency electromagnetic fields (ELF-EMF) may be due, at least in part, to the effect of these fields on neurotrophic factors levels and cell survival, leading to an improvement in behavior. This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease. Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative stress biomarker levels were monitored in Wistar rats. Rats were given 3NP over four consecutive days (20 mg/kg body weight), whereas ELFEF (60 Hz and 0.7 mT) was applied over 21 days, starting after the last injection of 3NP. Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and the forced swim test (FST), and displayed significant differences in neurotrophic factor levels and oxidative stress biomarkers levels, together with a neuronal damage and diminished neuronal density, with respect neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats. ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool.

Straightforward estimation of the elastic constants of an isotropic cube excited by a single percussion.

Ritz's method is applied to calculate accurate values of the lowest non-dimensional natural frequencies of a freely vibrating isotropic cube. The dependence of such frequencies and their quotients on Poisson's ratio is established. Vibration of a cube caused by percussion is detected at a point by a laser interferometer. With the help of the tables and graphs provided and with the values of the first lowest frequencies obtained experimentally in a single test, Poisson's ratio and the shear modulus are calculated by means of elementary arithmetical operations.

Toxicidad pulmonar asociada al empleo de oxígeno hiperbárico: procedimientos de cálculo / Pulmonary toxicity is associated with the hyperbaric oxygen: methods of calculation

OBJETIVOS: Estudiar si una exposición hiperbárica de larga duración motivada por la aparición de una enfermedad descompresiva bajo presión, presenta alteraciones espirométricas y si éstas están acompañadas de sintomatología clínica pulmonar compatible con toxicidad pulmonar por oxígeno. PACIENTES Y MÉTODO: 3 buceadores profesionales que durante una inmersión a 100 metros de profundidad, uno de ellos presenta, antes de terminar la inmersión una patología descompresiva que requiere aumentar los tiempos de respiración de oxígeno, se realizan espirometrías pre- y post-inmersión midiendo: FVC, FEV1, PEF, FEV1/FVC, FEF25-75, FEF 75-85, FEF 25, FEF 50, FEF 75. RESULTADOS: Los resultados post-inmersión demuestran un descenso global de todos los parámetros estudiados destacando el descenso de PEF (12.8%), FEF 50 (9,3%) y FEV1 (8.8%), de forma individual 2 buceadores mostraron descenso de todos los parámetros mientras que un buceador de los nueve parámetros estudiados solo experimentó descenso en cinco. Estos resultados no estuvieron acompañados de sintomatología pulmonar y carecieron de significado estadístico. CONCLUSIONES: Tras esta exposición hiperbárica se alteró el flujo y la capacidad sin la presencia de sintomatología clínica pulmonar y papel importante de la susceptibilidad individual. Los estudios de función pulmonar se deberían extender a colectivos sometidos a: cambios constantes de presión y a la respiración de oxígeno, gas con efectos tóxicos agudos y a largo plazo (AU)

INTRODUCTION: We studied if one hyperbaric exposition in the long term with decompression sickness under pressure causes disturbances in the pulmonary functions and if they are related with clinical manifestations which are compatibles with pulmonary oxygen toxicity. PATIENTS AND METHOD.-Three professional divers carried out one immersion at 100 meters of deep, only one person displayed, before the immersion was finished, one decompression pathology which need increase the times breathing of oxygen, we valued the pulmonary functions pre and post immersion so we measured: FVC, FEV1, PEF, FEV1/FVC, FEF25-75, FEF 75-85, FEF 25, FEF 50 and FEF 75. RESULTS: The post immersion results showed one total decline of all studied parameters showed the decrease of PEF (12.8%), FEF 50 (9.3%) and FEV1 (8.8%), two divers showed one decline of all parameters meanwhile that one diver registered decrease only in five parameters. These results are not accompanied of pulmonary symptoms and of significant statistic. CONCLUSIONS: After this hyperbaric exposure, the flow and the capacity were disturbed but they did not show neither clinic pulmonary symptoms nor had one important role in the personal susceptibility. The studies of pulmonary function should include group with constant pressure changes and the breathing of oxygen, this gas have acute toxic effects in the long term (AU)

[Tuberculosis in the area of Lorca: to adapt or resist]. / Tuberculosis en la comarca de Lorca: adaptarse o resistir.

OBJECTIVE: We studied the epidemiological characteristic of tuberculosis in Lorca area, drug resistant and the effect of the immigration population (Ecuador) in this area. PATIENTS AND METHODS: A retrospective study for six years ago (1999, January to 2004, December) was realized. Epidemiological data, initial diagnostic probability, mycobacteria stain and cultive, drug resistance, treatment response, and epidemiological differences between immigrants and spain population were compared. RESULTS: Within 158 cases registered, 41.7 percent were immigrants with less than one year in Spain, the most part Ecuador population. We observed that extrapulmonar tuberculosis was lower initial diagnostic probability than pleural disease as well too haemoptisis, pleural pain and weight loss. It was identified positive micobacterial stain in 35.4 percent of respiratory samples. It was successfully results in 74 percent of cases and 13.9 percent of patients were lost, this result was frequently registered in immigrants, The isoniazide resistant in patients with not previous treatment was 5.3 percent and it was 9.5 percent in immigrants and 10.8 percent in Ecuador population. CONCLUSION: It is necessary improve: the diagnostic of extrapulmonar tuberculosis and avoid loss patient by programs of capture and then the successfully treatments raise. The isoniazide resistant in this area suggest that we must use initial four drug than tree and this manner not raise the drug resistant in the area.

Morphogenesis of rat experimental pulmonary emphysema induced by intratracheally administered papain: changes in elastic fibres.

The ultrastructural changes of elastic fibres in emphysematous lungs have been studied in men, but few works exist on this topic in experimental emphysematous animals. In this paper, the morphogenesis of emphysema and alterations of the elastic fibres produced by the instillation of papain are described by light and electron microscopy. Wistar rats were instilled through the trachea with papain at a rate of 3 mg/100 g animal weight. The animals were sacrificed 12 h, 3 days, 10 days and 60 days after enzyme instillation. The "Mean Linear Intercept" (MLI), the "Number of fenestrations/respiratory units" (NF) the "Number of macrophages per mm of alveolar wall" (NM) and the "Number of respiratory unit/mm2" (RU), both in the control and experimental groups were studied. Two months after treatment, the experimental group showed a strong increase in the MLI (p<0.001) and NF (p<0.001), and a diminished number of RU (p<0.05) compared with the control group. Partial correlation analysis showed a positive correlation only between MLI and NF. Twelve hours after papain instillation an inflammatory response was observed, the elastic fibres were ruptured, while the microfibrilar component remained. New formations of eulanin elastic fibres were observed three days post papain instillation. After ten days the interalveolar oedema had disappeared and the elastic fibres were of normal morphology although irregular groups of strips of elastic fibres were evident. A mixed pattern of panlobular, centrilobular and normal lung zones were observed. Two months after papain instillation abundant accumulations of elastic fibres of irregular outline were observed associated to collagen fibres. In conclusion, the morphometric parameters studied showed a significant progression of the emphysema. The strong correlation between NF and MLI suggested that papain-induced emphysema is principally caused by breaches of the alveolar walls. The results seem to point to a very abnormal remodelling process associated with elastic fibre regeneration, although there were no signs of destruction of these new fibres formed in emphysematous rat lung induced by papain.

Tuberculosis en la comarca de Lorca: adaptarse o resistir / Tuberculosis in the area of Lorca: to adapt or resist

Objetivo: analizar las características epidemiológicas de los casos de tuberculosis del área de salud de la comarca de Lorca, su resistencia a fármacos y el impacto de la población inmigrante mayoritaria (Ecuador) en la misma. Pacientes y métodos: estudio longitudinal, retrospectivo de 6 años de duración (de enero de 1999 a diciembre 2004). Se recogieron datos epidemiológicos de cada caso, probabilidad diagnóstica inicial, tinciones diagnósticas, aislamientos, resistencia a fármacos, respuesta al tratamiento, así como, las diferencias epidemiológicas existentes entre inmigrantes y autóctonos. Resultados: Se identificaron 158 casos, 41,7% eran inmigrantes con menos de 1 año de estancia en nuestro país, mayoritariamente procedentes de Ecuador. Observamos que la tuberculosis extrapulmonar para el clínico tenía una probabilidad diagnóstica baja, mientras que la pleural era alta, junto a síntomas como hemoptisis, dolor pleurítico y constitucionales. En 35,4% de los casos se idéntifico germen por tinción en muestras respiratorias. Se obtuvo un 74% de resultados satisfactorios por el tratamiento y 13,9% de abandono asociado frecuentemente con la inmigración. La resistencia a isoniazida en no tratados fue del 5,3% en el área, 9,5% en el caso de inmigrantes y 10,8% en los oriúndos de Ecuador. Conclusión: Se debe mejorar en: la detección de los casos extrapulmonares, evitar el abandono con la captación de los enfermos y la curación de enfermedad. Las resistencias a isoniazida en nuestra área sugiere adaptarse a tratamientos de inicio con cuatro fármacos y no a tres para evitar incremento de resistencias en nuestra área de salud

Objective: We studied the epidemiological characteristic of tuberculosis in Lorca area, drug resistant and the effect of the immigration population (Ecuador) in this area. Patients and methods: A retrospective study for six years ago (1999, January to 2004, December) was realized. Epidemiological data, initial diagnostic probability, mycobacteria stain and cultive, drug resistance, treatment response, and epidemiological differences between immigrants and spain population were compared. Results: Within 158 cases registred, 41.7 percent were immigrants with less than one year in Spain, the most part Ecuador population. We observed that extrapulmonar tuberculosis was lower initial diagnostic probability than pleural disease as well too haemoptisis, pleural pain and weight loss. It was identified positive micobacterial stain in 35.4 percent of respiratory samples. It was succesfully results in 74 percent of cases and 13.9 percent of patients were lost, this result was frecuently registred in immigrants, The isoniazide resistant in patients with not previous treatment was 5.3 percent and it was 9.5 percent in immigrants and 10.8 percent in Ecuador population. Conclusion: It is necessary improve: the diagnostic of extrapulmonar tuberculosis and avoid loss patient by programs of capture and then the succesfully treatments raise. The isoniazide resistant in this area suggest that we must use initial four drug than tree and this manner not raise the drug resistant in the area

Influence of residency training on personal stress and impairment in family life: analysis of related factors.

OBJECTIVES: This cross-sectional study was designed to assess the level of stress among residents and stress-related impairment of family life. SUBJECTS AND METHODS: A 41-item anonymous questionnaire was designed to determine the level of stress and its effects on the residents' family as well as factors associated with stress during residency training in a tertiary-care hospital accredited with official resident training 'Medicos Internos Residentes' in Murcia, Spain. Questionnaires were distributed in sealed nominal envelopes during February and March 2002 to 227 eligible residents. RESULTS: Of the 227 residents, 175 (77%) completed and returned the questionnaires. Forty-two percent of residents recognized that residency training caused an important level of stress and 21% felt that stress interfered with family relationships. Both factors were significantly associated. Feelings of being unsatisfied with supervision of care and achievement of training objectives as well as low satisfaction with residency training and poor assessment of the hospital were significant stressors. Impairment in family life was significantly dependent on degree of satisfaction with residency training and evaluation of the hospital. CONCLUSION: The data showed that residency training generated stress and impaired family life. These were closely associated with perception of being unsatisfied with the residency training and evaluation.

Respuesta pulmonar ante una exposición hiperóxica controla. Valoración de 4 buceadores militares / Pulmonary response to a controlled hyperroxidic exposure

El oxígeno a presiones superiores a la atmosférica se emplea en la oxigenoterapia hiperbárica (OHC), buceo en saturación tratamiento de las patologías disbáricas. La OHB expone al sujeto a los efectos tóxicos de los radicales libres que pueden afectar la función pulmonar. Las tablas de tratamiento de accidentes de buceo presentan valores UPTD dentro de rangos no tóxicos, lo que no implica una afectación pulmonar. Realizamos a 4 buceadores tratados, al mismo tiempo, con tabla 6 (Uptd=625) estudios de función pulmonar al concluir el tratamiento y 14 horas después. El uso de la tabla 6 para accidentes de buceo produce una afectación pulmonar de carácter asintomático y reversible (AU)

Oxygen, with higher pressures than atmosphere ones, is used in hyperbaric oxygen theraphy (OHB), saturation´s diving and for the treatment of the disbaric pathologies. The subject is exposed by the OHB to the toxic effects of the free radicals, which can effect the pulmonary function. The tables of treatments for diving accidents present UPTD values within no toxic ranges, an it does not implies a pulmonary damage. We have done to 4 divers treated, at the same time, using table 6 (UPTD=625) studies of pulmonary function at the end of treatment and 14 hours later. After treatment values: FVC% (104,75 ±7.9), FEV1% (91,25±10,81), FEV1/FVC% (74±3.55), FEF 25-75% (70.5±12.23) FEF, 75-85% (69.5±15.5). Values of 14 hours later. FVC% (109.25±8.09), FEV1% (96,75±11.84), FEV1/FVC (74.75±3.77), FEF 25-75% (76±14.16), FEF 75-85% (76.5 ± 15.84). The use of table 6 for diving accidents produces an asymptomatic and reversible pulmonary affection (AU)

Hemoptisis: revisión de 70 casos / Hemoptysis: a review of 70 cases

Objetivos: Conocer las características etiológicas de los pacientes ingresados en la sección de Neumología por hemoptisis y su distribución en nuestro medio con relación a otras series. Métodos: Se realizó un estudio retrospectivo revisando las historias clínicas de los pacientes diagnosticados de hemoptisis en el servicio de neumología del Hospital Universitario Virgen de la Arrixaca, durante el año 2002. Resultados: Se estudiaron 70 pacientes, de los cuales 15 (21,4%) eran mujeres, y 55 hombres (78,5%). La edad media fue de 58,7 años. Fumadores y exfumadores de menos de 10 años constituyeron el 48,6%, exfumadores de más de 10 años 17,14%, no fumadores 35,7%. Los diagnósticos obtenidos fueron: bronquiectasias 24,3%, cáncer de pulmón 20%, infecciones respiratorias 12,8%, criptogenéticas 11,4%, bronquitis crónica 8,5%, TBC activa 7,1%, lesiones residuales por TBC 4,3%; abscesos 2,8%; sobredosificación por dicumarínicos 2,8%, malformaciones vasculares 2,8%, aspergiloma 1,4% fibrosis pulmonar 1,4%. Por rangos de edad encontramos diferencias, presentándose como primera causa en pacientes en mayores de 80 años y entre 50-59 años el cáncer de pulmón, entre 60 y 79 años las bronquiectasias y en los menores de 50 las infecciones respiratorias. El cáncer, también supone la primera causa en los pacientes fumadores y exfumadores desde hace menos de 10 años. Entre los exfumadores de más de 10 años destacan las bronquiectasias y en los no fumadores las infecciones respiratorias. En cuanto al diagnóstico la TC es diagnóstica en el 61,1%, la RX tórax en el 44,4% y la broncoscopia en el 11,1%; aunque localiza el sangrado en hasta el 47,2%. Conclusiones: La causa más frecuente de hemoptisis en nuestro medio es la secundaria a bronquiectasias, seguidas del cáncer de pulmón y de las infecciones respiratorias (AU)

Objectives: The aim of this review is know the etiology of hemoptysis in pneumology´s patients and its distribution in ours area compared with others series. Methods: We have made a restrospective and descriptive study about the clinical records of patients with diagnosis of hemoptysis in pneumology section from our hospital during the year 2002. Results: We have studied 70 clinical reports: 15 (21.4%) were women and 55 men (78.5%). The mean age was 58.7 years. Smoker and ex-smoker of less than 10 years were 48.6%, ex-smoker of more than10 years were 17.14% and non-smoker were 35.7%. The result included the following diagnosis: bronchiectasis 24.3%, lung cancer 20%, respiratory infecctions 12.8%, criptogenic 11.4%, chronic bronchitis 8.5%, active TBC 7.1%, residual lesions of TBC 4.3% abscess 2.8%, overdosis of anticoagulants 2.8%, vascular malformation 2.8%, aspergilloma 1.4% pulmonary fibrosis 1.4%. For age intervals we found differences: In the intervals 81-90 years and 51-60 years the main cause were lung cancer, between 61-80 years were bronchyectasis and <50 years respiratory infecitons. The lung cancer were also the most important cause the hemoptysis among the smokers and ex-smokers of less than 10 years. In non-smokers were the bronchiectasis. Conclusion: Bronchiectasis, lung cancer, and respiratory infections are the most common causes of hemoptysis in our area. In the same way that others series, we have found a important descent of impact of tuberculosis, but not in the bronchiectasis, as in others mediterraneans countries, where in their series is the main cause of hemoptysis (AU)

Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial.

OBJECTIVE: The aim of the present study is to investigate the effect of antioxidant polyphenol-rich pomegranate juice (PJ) supplementation for 5 weeks on patients with stable chronic obstructive pulmonary disease (COPD), since the oxidative stress plays a major role in the evolution and pathophysiology of COPD. DESIGN: A randomized, double-blind, placebo-controlled trial was conducted. SUBJECTS: A total of 30 patients with stable COPD were randomly distributed in two groups (15 patients each). INTERVENTIONS: Both groups consumed either 400 ml PJ daily or matched placebo (synthetic orange-flavoured drink) for 5 weeks. Trolox Equivalent Antioxidant Capacity (TEAC) of PJ, blood parameters (14 haematological and 18 serobiochemical), respiratory function variables, bioavailability of PJ polyphenols (plasma and urine) and urinary isoprostane (8-iso-PGF(2alpha)) were evaluated. RESULTS: The daily dose of PJ (containing 2.66 g polyphenols) provided 4 mmol/l TEAC. None of the polyphenols present in PJ were detected in plasma or in urine of volunteers. The most abundant PJ polyphenols, ellagitannins, were metabolized by the colonic microflora of COPD patients to yield two major metabolites in both plasma and urine (dibenzopyranone derivatives) with no TEAC. No differences were found (P > 0.05) between PJ and placebo groups for any of the parameters evaluated (serobiochemical and haematological), urinary 8-iso-PGF(2alpha), respiratory function variables and clinical symptoms of COPD patients. CONCLUSIONS: Our results suggest that PJ supplementation adds no benefit to the current standard therapy in patients with stable COPD. The high TEAC of PJ cannot be extrapolated in vivo probably due to the metabolism of its polyphenols by the colonic microflora. The understanding of the different bioavailability of dietary polyphenols is critical before claiming any antioxidant-related health benefit. SPONSORSHIP: 'Fundación Séneca' (Murcia, Spain), Project PB/18/FS/02 and Spanish CICYT, Project AGL2003-02195.

Cold urticaria associated with acute serologic toxoplasmosis.

Cold urticaria is defined as a urticarial and/or angioedematous reaction of the skin to contact with cold objects, water or air. Types of urticaria associated with infectious diseases, such as mononucleosis, rubeola, varicella, syphilis, hepatitis, and HIV infection have been reported. We present the case of a patient who developed cold urticaria associated with acute serologic toxoplasmosis. The patient was a 34-year-old man who for the previous 2 months had presented cutaneous pruritus accompanied by several papular lesions in parts of the skin exposed to cold as well as those in contact with cold water. The result of an "ice-cube test" was positive. Serologic tests for Toxoplasma gondii showed an IgG level of 68 UI/ml and were positive for IgM, while a test for cryoglobulins was positive. One month later cryoglobulins were negative and a serologic test for T. gondii showed an IgG concentration of 75 UI/ml and positive IgM. Three months later cryoglobulins were still negative, IgG for T. gondii was 84 UI/ml, and IgM was positive. After 6 months cryoglobulins were still negative, IgG level was 68 UI/ml and IgM was still slightly positive. In the final evaluation, 14 months later, IgG level was 32 UI/ml and IgM was negative. The patient continues to present clinical manifestations of cold urticaria, although he has experienced some improvement and his tolerance to cold has increased after treatment with cetirizine.