[Successful local treatment of a digital canine mast cell tumour with Tigilanol Tiglate]. / Erfolgreiche lokale Behandlung eines digitalen kaninen Mastzelltumors mit Tigilanoltiglat.

Surgical excision is currently the recommended treatment for resectable, nonmetastatic mast cell tumours. Recently, Tigilanol tiglate has become available as a novel intratumoral treatment modality for a subset of cutaneous and subcutaneous mast cell tumours. In the presented case, we document the successful treatment of a 0.445 cm3 subcutaneous digital mast cell tumour in an American Staffordshire Terrier. The resulting wound healed completely and without complications within 4 weeks and the dog was recurrence-free 8 months after treatment. Due to this new intratumoral treatment it was possible to preserve the digit, while a complete surgical resection of the tumour would have required digital amputation.

[Hormone-producing thyroid carcinoma in a female 10-year-old Australian Cattle Dog]. / Hormonproduzierendes Schilddrüsenkarzinom bei einer 10-jährigen Australian-Cattle-Dog-Hündin.

A 10-year-old female Australian Cattle Dog was referred for investigation of a mediastinal mass. During clinical examination, a mandarin- sized mass was detected ventrally of the trachea. According to computed tomographic (CT) findings and cytology of a fine-needle aspirate, thyroid neoplasia was suspected. The assumed tumour affected the left thyroid gland and was staged as stadium II because of enlargement of the ipsilateral cervical and retropharyngeal lymph nodes. The left thyroid, including the parathyroid gland, was removed surgically with a guarded prognosis. Histological examination revealed a follicular thyroid adenocarcinoma. The total thyroxine level was slightly elevated preoperatively. Postoperatively, the dog developed persistent hypothyroidism. A mediastinal mass could not be identified on the CT scan.

Investigations on the conjunctival goblet cells and on the characteristics of glands associated with the eye in the guinea pig.

OBJECTIVE: To investigate the distribution and density of conjunctival goblet cells (GC) and to study the anatomy and microscopic characteristics of glands associated with the eye in the guinea pig. PROCEDURES: Twenty-five guinea pigs were used. Meibomian gland openings were counted using biomicroscopy. Conjunctiva, eyelids and glands were embedded in glycol methacrylate and paraffin. Sections were stained with hematoxylin and eosin (H&E), periodic acid Schiff's reaction (PAS) and Alcian blue (AB). RESULTS: Highest GC densities were found in the bulbar and palpebral region of the nasal conjunctiva (GC index: 13.7-16.4%). Lowest GC densities (GC index: 0.0-1.0%) were found in 3/4 limbal regions (nasal and temporal upper eyelid, temporal lower eyelid). Guinea pigs have 27.1±3.0 (mean±SD) meibomian gland openings in the upper lid and 25.7±2.3 in the lower lid. Difference between upper and lower lid was significant (P=0.037). Two subconjunctival sebaceous glands occur temporal to each eye. The Harderian gland is very large. In the lacrimal gland three different cell types were distinguished both according to the cell structure and histochemical staining. CONCLUSIONS: Goblet cell densities are lower in guinea pigs than in dogs and horses. Positive staining with PAS and AB could be an indication that mucins are produced in the lacrimal gland. If so, they may contribute to the mucin layer of the tear film. Both the extraordinarily large Harderian gland and the subconjunctival sebaceous glands produce lipids and may contribute to the lipid layer of the tear film.