1.
Ann Trop Med Parasitol
; 96(6): 553-7, 2002 Sep.
Article
in English
| MEDLINE
| ID: mdl-12396318
ABSTRACT
To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.
Subject(s)
Antimalarials/therapeutic use , Chloroquine/therapeutic use , Malaria, Falciparum/drug therapy , Acute Disease , Adolescent , Adult , Animals , Child , Child, Preschool , Female , Genotype , Humans , Infant , Laos , Male , Middle Aged , Plasmodium falciparum/genetics , Quality Control , Recurrence , Treatment Failure , Treatment Outcome
2.
Lancet
; 354(9182): 955-6, 1999 Sep 11.
Article
in English
| MEDLINE
| ID: mdl-10489988