Characterizing the risk related to the exposure to methylmercury over a lifetime: A global approach using population internal exposure.

Seafood products accumulate methylmercury throughout the food chain and are the main source of methylmercury exposure. Methylmercury may trigger a number of adverse health effects, such as neurodevelopmental or nephrotoxic effects, the risk of which cannot be ruled out for the French high consumers of seafood. The characterisation of methylmercury-related risks is generally based on short-term dietary exposure without considering changes in consumption and exposure over the lifetime. Additionally, focusing on short-term dietary exposure, the fate of methylmercury (especially its accumulation) in the organism is not considered. The present study proposes a methodology basing risk characterization on estimates of body burden over a lifetime. First, trajectories of dietary exposures throughout lifetime were constructed based on the actual concentrations of total diet studies for a fictive representative French population, taking into account the social, economic and demographic parameters of individuals. Next, the fate of methylmercury in the body was estimated, based on these trajectories, using a specific physiologically-based kinetic (PBK) model that generated a representative pool of body burden trajectories. Simulated hair mercury concentrations were closed to previously reported French representative human biomonitoring data. Results showed that at certain stages of life, concentrations of methylmercury in hair were higher than the human biomonitoring guidance value set at 2.5 µg/g of hair by JECFA. This study showed the added value, in the case of substances accumulating in the body, of estimating dietary exposure over a lifetime and using exposure biomarkers estimated by a PBK model characterize the risk.

Characterisation of the risk associated with chronic lifetime exposure to mixture of chemical hazards: case study of trace elements.

Risk assessment methodology, mostly commonly used, faces the complexity of the environment. Populations are exposed to multiple sources of chemicals throughout life and the chemical mixtures they are exposed change during time (lifestyle factors, regulatory decisions, etc). The risk assessment needs to consider these dynamics and the evolution of the body with age, in order to refine the exposure assessment to chemicals and to predict the health impact of these exposures. This review highlights the latest methodologies developed to improve risk assessment, especially cor heavy metals. The methodologies aim to better describe the chemical toxicokinetic and toxicodynamic as well as the exposure assessment. Human Biomonitoring (HBM) data give great opportunities to link biomarkers of exposure with an adverse effect. Physiologically-Based Toxicokinetic (PBTK) models are more and more used to simulate the evolution of biomarkers in organisms, considering the external exposures and the physiological evolutions. PBTK models may also be used to determine the routes of exposure or to predict the impacts of schemes of exposure. The major limit is the integration of several chemicals in mixture with common adverse effects and the interactions between them.