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Perinatal Brain Injury is Accompanied by Disturbances in Expression of SLC Protein Superfamily in Endotheliocytes of Hippocampal Microvessels.
Morgun, A V; Kuvacheva, N V; Khilazheva, E D; Pozhilenkova, E A; Gorina, Ya V; Malinovskaya, N A; Komleva, Yu K; Lopatina, O L; Panina, Yu A; Gasymly, E D; Salmina, A B.
Bull Exp Biol Med ; 161(6): 770-774, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27783302

ABSTRACT

The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.


Subject(s)
Anxiety, Separation/genetics , Glucose Transporter Type 4/genetics , Glycogen Synthase Kinase 3/genetics , Hypoxia-Inducible Factor 1, alpha Subunit/genetics , Hypoxia/genetics , Stress, Psychological/genetics , Age Factors , Animals , Animals, Newborn , Anxiety, Separation/complications , Anxiety, Separation/metabolism , Anxiety, Separation/pathology , Astrocytes/metabolism , Astrocytes/pathology , Blood-Brain Barrier/metabolism , Blood-Brain Barrier/pathology , Endothelial Cells/metabolism , Endothelial Cells/pathology , Female , Gene Expression Regulation , Glucose Transporter Type 4/metabolism , Glycogen Synthase Kinase 3/metabolism , Hippocampus/blood supply , Hippocampus/metabolism , Hippocampus/pathology , Humans , Hypoxia/complications , Hypoxia/metabolism , Hypoxia/pathology , Hypoxia-Inducible Factor 1, alpha Subunit/metabolism , Male , Microvessels/metabolism , Microvessels/pathology , Neurons/metabolism , Neurons/pathology , Neurovascular Coupling , Rats , Rats, Wistar , Stress, Psychological/complications , Stress, Psychological/metabolism , Stress, Psychological/pathology
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