ABSTRACT
Se comentan los recientes aportes terapéuticos, dividiéndose el trabajo en los siguientes capítulos: I)Resistencia bacteriana a los diversos fármacos, en especial a la D.D.S. en su forma secundaria, así como la primaria. Dosis a emplear con la monoterapia. Causas de aparición de la resistencia (tratamiento irregular y/o bajas dosis). II) Asociación medicamentosa: sus ventajas y los principales esquemas en enfermos vírgenes y en casos de resistencia a las sulfonas. III) Tratamiento de la reacción leprosa. IV) Inmunoterapia en lepra: sus objetivos, los medios más comúnmente empleados, sus riesgos y efectos colaterales
Subject(s)
Humans , Leprosy/drug therapy , Leprosy/therapy , Sulfones/administration & dosage , Sulfones/therapeutic use , Rifampin/administration & dosage , Rifampin/adverse effects , Rifampin/therapeutic use , Drug Resistance, Microbial , Transfer Factor/therapeutic use , Levamisole/adverse effects , Levamisole/therapeutic use , BCG Vaccine/adverse effects , BCG Vaccine/therapeutic use , Diphtheria Toxoid/adverse effects , Diphtheria Toxoid/therapeutic use , ImmunotherapyABSTRACT
Se comentan los recientes aportes terapéuticos, dividiéndose el trabajo en los siguientes capítulos: I)Resistencia bacteriana a los diversos fármacos, en especial a la D.D.S. en su forma secundaria, así como la primaria. Dosis a emplear con la monoterapia. Causas de aparición de la resistencia (tratamiento irregular y/o bajas dosis). II) Asociación medicamentosa: sus ventajas y los principales esquemas en enfermos vírgenes y en casos de resistencia a las sulfonas. III) Tratamiento de la reacción leprosa. IV) Inmunoterapia en lepra: sus objetivos, los medios más comúnmente empleados, sus riesgos y efectos colaterales
Subject(s)
Humans , Leprosy/drug therapy , Rifampin/administration & dosage , Rifampin/adverse effects , Rifampin/therapeutic use , Sulfones/administration & dosage , Sulfones/therapeutic use , Drug Resistance, Microbial , BCG Vaccine/adverse effects , BCG Vaccine/therapeutic use , Levamisole/adverse effects , Levamisole/therapeutic use , Transfer Factor/therapeutic use , Immunotherapy , Leprosy/therapy , Diphtheria Toxoid/adverse effects , Diphtheria Toxoid/therapeutic useSubject(s)
Middle Aged , Humans , Male , Crohn Disease/complications , Rectal Fistula/etiology , Skin Diseases/etiologyABSTRACT
It has been analyzed seven patients, five females and two males, affected by progressive systemic sclerosis. Their ages range from 35 to 60 years. Three of them correspond to the CREST syndrome named variant. There were made: physical examination, electrocardiogram, echocardiogram and radionuclide techniques such as: Thallium perfusion (T201) and ventriculography (Tc99). The cardiac examination of all the patients showed: Left myocardiopathy in six patients, as well right myocardiopathy in two of them. Four patients were affected by chronic cor pulmonale, due to pulmonary hypertension. All the patients had developed diffuse thallium perfusion defects as well, having abnormal resting left ventricular function in three patients and function abnormality from right ventricle in two patients. It is necessary to point out the importance of making such study systematically, even in the case cardiac symptoms absence.
Subject(s)
Cardiomyopathies/etiology , Scleroderma, Systemic/complications , Adult , Cardiomyopathies/diagnostic imaging , Cardiomyopathies/physiopathology , Echocardiography , Female , Humans , Male , Middle Aged , Radionuclide ImagingSubject(s)
Dapsone/urine , Leprosy/drug therapy , Dapsone/therapeutic use , Humans , Patient ComplianceABSTRACT
The contribution of non-specific suppressor mechanisms to the overall immunoregulatory defect observed in lepromatous leprosy was evaluated. Con A-induced suppression was assayed using the standard two-stage test in 27 lepromatous leprosy patients, 19 of them during the quiescent stage (LL) and eight during erythema nodosum lepromatosum (ENL). Lymphocytes from normal individuals react in this assay, yielding higher suppression as the numbers of Con A-induced suppressor cells (Leu 2a+ cells) increase. In contrast, two patterns of response were observed in both LL and ENL patients: those giving lower suppression as the number of suppressor cells increased (LL-A and ENL-A) and those responding with the normal pattern (LL-B and ENL-B). The abnormal dose-response profile was not related to the disease stage, as both ENL and LL patients were included in groups with normal or atypical response. Reaction of the potential suppressor cells with anti-Leu 2a antibody abolished suppression in LL-B and normals, whereas Con A-induced suppression was unchanged or higher in ENL-A, ENL-B and LL-A, indicating that in these patients Leu 2a+ cells interfered with the generation of Con A-induced suppression. The contribution of spontaneous suppression was examined and it was shown that suppressor activity in the absence of Con A stimulus was higher in ENL (both ENL-A and ENL-B) and LL-A. Thus, it appears that the occurrence of high spontaneous suppressor activity, probably related to in vivo activation, is associated with a relative inability to generate de novo suppression after Con A stimulation in these patients.
Subject(s)
Immune Tolerance , Leprosy/immunology , T-Lymphocytes, Regulatory/immunology , Adult , Aged , Antibodies, Monoclonal , Concanavalin A/pharmacology , Erythema Nodosum/immunology , Female , Humans , Male , Middle AgedABSTRACT
Two females patients with CREST syndrome associated with cardiac involvement are reported. One of them has pericardial effusion just shown by echocardiography with patterns of cardiomyopathy of ventricular cavities, the latter as primary myocardial involvement, in the absence of pulmonary or systemic hypertension. The second patient has chronic cor pulmonale secondary to pulmonary hypertension verified by electrocardiography and echocardiography. It is emphasized the utility of the echocardiography and the importance of those anomalies that can lead to the patient's death, transforming the CREST towards a syndrome with potentially but late, severe systemic involvement.
Subject(s)
Cardiomegaly/etiology , Hypertension, Pulmonary/etiology , Pulmonary Heart Disease/etiology , Scleroderma, Systemic/complications , Adult , Female , Humans , Middle Aged , Pericardial Effusion/etiology , SyndromeABSTRACT
We present the case of a patient thirty seven years old who has angiolymphoid hyperplasia with eosinophilia, diagnosis confirmed by histopathological examination, localized in ear's pavilion, ear's outer duct and beyond the ear. She has received intralesional injections of corticoid (because of a possible misdiagnosis). This provoked the appearance of a pyogenous process with a profuse, purulent and fetid secretion (Staphylococcus aureus) resistant to many antibiotics which was finally controlled with trimethoprim-sulfamethoxazole. We controlled the disease with radiotherapy applications and afterwards partial cryosurgery.
Subject(s)
Angiolymphoid Hyperplasia with Eosinophilia/pathology , Adult , Angiolymphoid Hyperplasia with Eosinophilia/drug therapy , Angiolymphoid Hyperplasia with Eosinophilia/radiotherapy , Biopsy , Combined Modality Therapy , Ear, External/pathology , Female , HumansABSTRACT
One hundred and twenty-one patients with tinea (pityriasis) versicolor, confirmed by pretherapeutic clinical and mycological examination, were treated with a single daily application of bifonazole (BAY h 4502) 1% gel for 2 weeks. Weekly clinical controls were performed during the treatment period and at least two clinical and mycological post-therapeutic controls were given. Overall results were very good in 98 patients, good in 15, moderate in 7 and failure in 1 patient. Local tolerance was very good; only 1 patient presented with slight erythema and pruritus during the treatment.
Subject(s)
Antifungal Agents/therapeutic use , Imidazoles/therapeutic use , Tinea Versicolor/drug therapy , Adolescent , Adult , Child , Female , Humans , Male , Middle AgedABSTRACT
Se estudiaron 45 enfermos de lepra indeterminada confirmados clínco-histologicamente, entre lis años 1975-1982. 24 fueron de sexo masculino y 21 feminino. La edad de aparición de la enfermedad, en el 48'8 por ciento de los casos, fue entre 11 y 30 años. El proceso fue diagnosticado dentro del primer año de iniciado en 46,6 por ciento de los pacientes. Las localizaciones preferenciales fueron: miembros inferiores, superiores cara y tronco. en 44 enfermos la baciloscopía fue negativa y en el 68'8 por ciento la lepromina positiva. 13 casos, 28,8 por ciento dados de alta por curación total, luego de un tiempo promedio de tratamiento de 8'4 años.
Subject(s)
Leprosy/classification , Leprosy/etiologySubject(s)
Pregnancy , Humans , Female , Pregnancy Complications, Infectious , Leprosy , Postpartum Period , Fetal DevelopmentABSTRACT
Se presenta el caso de un paciente varon de 28 anos de edad, argentino con caracteristicas fenotipicas del sindrome de Turner, pero con cariotipo normal.Se diagnostica sindrome de Noonan.Se realiza una revision completa del cuadro describiendo prolijamente las manifestaciones dermatologicas, asi como los demas signos clinicos que caracterizan al sindrome
Subject(s)
Adult , Humans , Male , Noonan SyndromeSubject(s)
Pregnancy , Humans , Female , Leprosy , Postpartum Period , Pregnancy Complications, Infectious , Fetal DevelopmentABSTRACT
Se presenta el caso de un paciente varon de 28 anos de edad, argentino con caracteristicas fenotipicas del sindrome de Turner, pero con cariotipo normal.Se diagnostica sindrome de Noonan.Se realiza una revision completa del cuadro describiendo prolijamente las manifestaciones dermatologicas, asi como los demas signos clinicos que caracterizan al sindrome
Subject(s)
Adult , Humans , Male , Noonan SyndromeSubject(s)
Leprosy/physiopathology , Neuritis/etiology , Peripheral Nervous System Diseases/etiology , Autonomic Nervous System/physiopathology , Combined Modality Therapy , Diagnosis, Differential , Edema/etiology , Humans , Leprosy/therapy , Muscle Contraction , Mycobacterium leprae/physiology , Nerve Compression Syndromes/etiology , Neural Conduction , Pain , Paresthesia/etiology , Peripheral Nerves/microbiology , Peripheral Nervous System Diseases/diagnosis , Peripheral Nervous System Diseases/therapyABSTRACT
Se evalua el estado inmunitario en 20 pacientes al momento de efectuar el diagnostico de melanoma, realizandose pruebas de inmunidad celular "in vivo" (candidina, PPD, DNCB y ventana cutanea) y humoral (proteinograma, inmunoelectroforesis, dosaje de complemento, SIA test, COOMBS directo, latex y celulas L.E.). El seguimiento de los mismos, comprendio un periodo maximo de hasta 6 anos. Se intenta relacionar el estado inmunitario inicial con el potencial evolutivo del melanoma
