ABSTRACT
Parameters of quality of life (QOL) measured with the SF-36 questionnaire were studied in 91 patients with torticollis (ST) treated with botulinum toxin A. A control group comprised 50 subjects without ST. The QOL parameters were lower in patients compared to controls. Effects of age, education and illness severity on QOL were found. The illness duration was inversely correlated with QOL parameters. Disabled patients with ST had lower scores on the psychological domain that indicated the poor social adjustment, higher levels of anxiety and depression in this group. The treatment with botulinum toxin A allows to improve significantly QOL in patients with ST and exerts a positive effect on all QOL parameters, with the best improvement on the physical domain after the first injection and psychological domain after the following ones.
Subject(s)
Botulinum Toxins, Type A/therapeutic use , Neuromuscular Agents/therapeutic use , Quality of Life , Torticollis/psychology , Adolescent , Adult , Aged , Botulinum Toxins, Type A/administration & dosage , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neuromuscular Agents/administration & dosage , Retrospective Studies , Surveys and Questionnaires , Time Factors , Torticollis/drug therapy , Treatment Outcome , Young AdultSubject(s)
Health Resorts , Occupational Diseases/rehabilitation , Physical Therapy Modalities , Adult , Antibody Formation/immunology , Female , Hemodynamics/physiology , Humans , Male , Middle Aged , Occupational Diseases/immunology , Occupational Diseases/physiopathology , Respiratory Mechanics/physiology , Siberia , Treatment OutcomeABSTRACT
Theophylline salivary and serum concentrations (Tser and Tsal) were quantified after a single dose administration of theophylline drugs: euphylline (2.4% solution, 10 ml i.v. jet and 0.15 orally), theo-dur, retaphil, theopek, theobilong (0.3 g orally). The drugs were given to patients with broncho-obstructive syndrome. The samples were obtained within 6 and 24 hours upon administration for euphylline and other drugs, respectively. Tser and Tsal were determined at high-performance liquid chromatography. The authors revealed a linear relationship between Tser and Tsal in different time intervals. The percentage factors and formulas of Tser calculation by its Tsal values have been estimated.
Subject(s)
Bronchial Diseases/metabolism , Saliva/chemistry , Theophylline/analysis , Adult , Aged , Aminophylline/administration & dosage , Aminophylline/analysis , Aminophylline/pharmacokinetics , Bronchial Diseases/drug therapy , Chromatography, High Pressure Liquid , Constriction, Pathologic/drug therapy , Constriction, Pathologic/metabolism , Delayed-Action Preparations , Female , Humans , Male , Middle Aged , Syndrome , Theophylline/administration & dosage , Theophylline/pharmacokinetics , Time FactorsSubject(s)
Asthma/drug therapy , Bronchitis/drug therapy , Bronchodilator Agents/administration & dosage , Cromolyn Sodium/administration & dosage , Fenoterol/administration & dosage , Adult , Aerosols , Aged , Asthma/physiopathology , Bronchitis/physiopathology , Bronchodilator Agents/adverse effects , Chronic Disease , Cromolyn Sodium/adverse effects , Drug Combinations , Drug Evaluation , Female , Fenoterol/adverse effects , Humans , Male , Middle Aged , Respiratory Function Tests , SafetyABSTRACT
The pharmacokinetics of five preparations of theophylline--euphylline and sustained-release forms (theo-dura, retaphylline, theopac and theobilong) was studied in 50 patients with the broncho-obstructive syndrome. Blood serum theophylline concentration was determined by high performance liquid chromatography. The main differences in the pharmacokinetic parameters manifested themselves in the period of half-absorption--the least one for euphylline and the greatest one for theopac. A close correlation between blood serum theophylline concentration and the profile of theophylline release from theopac tablets was revealed. The equal theophylline concentration in blood serum was determined on the 4th and 7th days of the course treatment with sustained-release preparations administered twice a day, the concentration values ranged within the subtherapeutic level. An increase of the dose by 50-150 mg/day resulted in an increase of blood serum theophylline concentration within the therapeutic range.
Subject(s)
Theophylline/pharmacokinetics , Administration, Oral , Adult , Aged , Asthma/blood , Asthma/drug therapy , Chromatography, High Pressure Liquid , Delayed-Action Preparations , Female , Humans , Male , Middle Aged , Spectrophotometry, Ultraviolet , Tablets , Theophylline/administration & dosage , Theophylline/blood , Time FactorsABSTRACT
Clinical efficiency of course treatment has been assessed for 5 long-acting drugs of theophylline series: retaphylline (Finland), theo-dur (Sweden), durophylline (Yugoslavia), theopek and theobilong (USSR). The drugs were tested in 139 patients with chronic++ bronchial obstruction. It was established that first-line therapy with theophylline should be started with low doses (400 mg/day) and last for 3 days to define individual sensitivity to theophylline drugs followed by increasing doses. On day 7 serum theophylline levels were to be measured for control and dose correction. In cross administration and adequate doses the drugs activity was similar. For patients suffering from nocturnal asthma attacks it was an atypical doze regimen implying administration of two-thirds of the day, dose in the evening that produced the highest effect. The incidence and severity of CNS, cardiovascular and gastrointestinal side effects varied with the dose blood concentration and individual sensitivity to theophylline.
Subject(s)
Bronchi/drug effects , Lung Diseases, Obstructive/drug therapy , Theophylline/therapeutic use , Adult , Aged , Delayed-Action Preparations , Dose-Response Relationship, Drug , Female , Humans , Male , Middle Aged , Theophylline/administration & dosageSubject(s)
Theophylline/pharmacology , Adolescent , Adult , Aged , Aminophylline/pharmacokinetics , Aminophylline/pharmacology , Asthma/blood , Asthma/drug therapy , Bronchitis/blood , Bronchitis/drug therapy , Chronic Disease , Delayed-Action Preparations , Drug Evaluation , Female , Humans , Male , Middle Aged , Theophylline/pharmacokineticsSubject(s)
Aminophylline/administration & dosage , Theophylline/administration & dosage , Administration, Oral , Adult , Aged , Aminophylline/blood , Asthma/blood , Asthma/drug therapy , Bronchial Spasm/blood , Bronchial Spasm/drug therapy , Bronchitis/blood , Bronchitis/drug therapy , Chronic Disease , Delayed-Action Preparations , Dose-Response Relationship, Drug , Drug Evaluation , Female , Humans , Injections, Intravenous , Male , Middle Aged , Theophylline/blood , Time FactorsSubject(s)
Asthma/drug therapy , Hemoperfusion , Theophylline/pharmacokinetics , Adult , Female , Humans , Models, Biological , Theophylline/blood , Theophylline/poisoningABSTRACT
Surgery was carried out in 1,229 cases (346 (28.1%) aged 60 and older) at the gynecological department of the Dispensary in 1976-1983. The operability rate in the aged and old-age bracket was 55.2%. Malignancies were registered in 239 benign tumors--in 107 cases. 16 patients died (4.6%), thromboembolism of the lung artery being the most frequent cause of postoperative mortality. A combination of neuroleptanalgetics, barbiturates and nitrous oxide is recommended for anesthesia.
