[The efficacy of the new bacterial preparation biosporin in treating acute intestinal infections]. / Effektivnost' novogo bakteriinogo preparata biosporina pri pechenii ostrykh kishechnykh ifektsii.

The clinico-laboratory study of the new probiotic Biosporin revealed its effectiveness in the treatment of patients with acute enteric infections. The pronounced curative action of the preparation, manifested by the rapid normalization of stool, the disappearance of abdominal pains and the decrease of dysbiosis in the intestine, was demonstrated. The best results were registered after the administration of Biosporin containing 2 x 10(9) microbial cells (Bacillus subtilis and Bacillus licheniformis). Biosporin was well tolerated by the patients, no side effects were observed. Biosporin is recommended for use in medical practice for the treatment of patients with acute enteric infections.

[Pathomorphology of the large intestinal mucosa in acute infectious colitis]. / Patomorfologiia slizistoi obolochki tolstoi kishki pri ostrykh infektsionnykh kolitakh.

634 biopsies of distal colon mucosa from 393 patients with acute intestinal bacterial and viral infections were studied histologically, histochemically and morphometrically. Acute catarrhal or catarrhal-hemorrhagic inflammation was found regardless of the colitis etiology (Shigella, Salmonella, Campylobacter, rotavirus). The most pronounced inflammation was in shigellosis and minimal one in rotavirus infection. Marked eosinophilic infiltration of the epithelium and tunica propria was observed in colonic contamination with C. pylori. Correlation analysis between morphometric indices in shigellosis and salmonellosis revealed a decrease in the number of strong functional links and the appearance of new ones indicating morphofunctional derangement.

[Morphological and morphometric characteristics of the large-intestinal mucosa in Campylobacter infections]. / Morfologicheskie i morfometricheskie osobennosti slizistoi obolochki tolstoi kishki pri kampilobakterioze.

Twenty-two biopsy specimens of colon mucosa were obtained from 16 patients with gastrointestinal campylobacteriosis histologically, histochemically and morphometrically. At the height of the disease colon mucosa of these patients showed a morphological picture of acute hemorrhagic and erosive--hemorrhagic colitis. When compared with such for other intestinal infections (shigellosis, salmonellosis, rotaviral gastroenteritis), the morphological features appeared to vary permitting a differential diagnosis with acute colitis due to above infections, but objective criteria to differentiate campylobacter-induced colitis from colitis in aggravation of nonspecific ulcerative one and Crohn's disease still remains to be found.

[Ribosomal dysentery vaccine. Study of response and antigenic activity in healthy volunteers]. / Ribosomal'naia dizenteriinaia vaktsina. Izuchenie reaktogennosti i antigennoi aktivnosti na zdorovykh dobrovol'tsakh.

In earlier studies Shigella sonnei ribosomal vaccine was shown to be highly protective for guinea pigs and monkeys. The object of the present study, carried out in 20 healthy volunteers, was the safety and the antigenic activity of this vaccine. The subcutaneous injection of the ribosomal vaccine in doses of 100 micrograms and 200 micrograms produced no febrile reactions nor biochemical and histological changes. The minimal local reaction was observed after injection into the subscapular region: in this case 200 micrograms of the vaccine produced neither severe, nor moderate reactions. A single injection of this dose led to a more than 4-fold rise in the levels of total and cysteine-resistant O-antibodies, as well as to the prolonged elevation of the complement level in the serum.