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Neuroprotective properties of afobazol in vitro.
Zenina, T A; Gavrish, I V; Melkumyan, D S; Seredenina, T S; Seredenin, S B.
Bull Exp Biol Med ; 140(2): 194-6, 2005 Aug.
Article in English, Russian | MEDLINE | ID: mdl-16282999

ABSTRACT

The effects of a novel selective anxiolytic afobazol on survival of HT-22 neurons were studied in the model of oxidative stress and glutamate toxicity. In both models, the neuroprotective effect of afobazol was established.


Subject(s)
Benzimidazoles/pharmacology , Morpholines/pharmacology , Neuroprotective Agents/pharmacology , Animals , Cell Line , Cell Survival , Glutamic Acid/chemistry , Glutamic Acid/metabolism , Hydrogen Peroxide/metabolism , In Vitro Techniques , Mice , Neurons/metabolism , Oxidative Stress , Tetrazolium Salts/pharmacology , Thiazoles/pharmacology , Time Factors
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