ABSTRACT
Between May and June 2001, efficacy of chloroquine was assessed in 5 sentinel sites in the 3 Comoro islands. Among the 183 children, age range between 6 and 59 months, followed up for 14 days, clinical failure rates ranged between 31.2 and 73.1% and the total failure rate (clinical and parasitological) between 50 and 88.5%. Failures were mainly early treatment failures. The Ministry of health, during a consensus meeting decided to change the first line drug and to gather baseline information on the efficacy and the tolerance of the combination artemether-lumefantrine. Between June and September 2004, among the 164 children, age range between 6 and 59 months included, the success rate of the combination was 99.4% in the 3 sites with a follow-up of 28 days. No serious drug related adverse event was reported.
Subject(s)
Antimalarials/therapeutic use , Artemisinins/therapeutic use , Chloroquine/therapeutic use , Drug Resistance , Ethanolamines/therapeutic use , Fluorenes/therapeutic use , Health Policy , Malaria, Falciparum/drug therapy , Plasmodium falciparum/drug effects , Animals , Antimalarials/administration & dosage , Antimalarials/pharmacology , Artemether , Artemisinins/administration & dosage , Artemisinins/pharmacology , Child , Child, Preschool , Chloroquine/administration & dosage , Chloroquine/pharmacology , Clinical Protocols , Comoros/epidemiology , Consensus Development Conferences as Topic , Drug Combinations , Ethanolamines/administration & dosage , Ethanolamines/pharmacology , Female , Fluorenes/administration & dosage , Fluorenes/pharmacology , Genotype , Health Policy/trends , Humans , Infant , Lumefantrine , Malaria, Falciparum/epidemiology , Malaria, Falciparum/parasitology , Malaria, Falciparum/prevention & control , Male , Plasmodium falciparum/genetics , Plasmodium falciparum/isolation & purification , Practice Guidelines as Topic , Public Health Administration , Recurrence , World Health OrganizationABSTRACT
Malgre les efforts deployes depuis des annees; le paludisme reste et demeure l'une des principales causes de morbidite et de mortalite au Togo. Les enfants de moins de 5 ans constituent la tranche d'age la plus vulnerable. Un effort reste a faire au niveau des institutions sanitaires afin que toutes les donnees statistiques permettant de bien cerner la situation; soient disponibles
Subject(s)
Malaria/epidemiology , Malaria/mortality , Malaria/prevention & control , MorbidityABSTRACT
Cette etude nous montre que 28 a 33 pour cent de femmes enceintes en ville et en milieu rural ne suivent aucune chimioprophylaxie. Malgre la chloroquino-resistance; 70 a 83 pour cent de souches sont sensibles a la dose de 5 mg/kg de chloroquine. A la lumiere du taux eleve de non observance de la chimiotherapie par les femmes enceintes en ville et en milieu rural; il convient de revoir la strategie d'information et d'education pour la sante
