Terguride in the treatment of hyperprolactinemia.

Thirty-two women with ovarian dysfunction due to hyperprolactinemia were treated with a new derivative of lisuride-terguride. Twenty-three patients were treated for infertility. A microadenoma was confirmed in five, and three other patients had had a macroprolactinoma surgically removed. The finding in one of the patients was diagnosed as the syndrome of empty sella. Galactorrhea was present in 18 women. The duration of treatment ranged from 2 to 33 months. The determination of therapeutic dosages was based on individual responses on the prolactin levels within a range from 0.1 to 4.5 mg per day. Increased prolactin levels were successfully normalized in twenty-one treated patients. Regular periods were reappeared in 59% of the women. Thirteen (56%) became pregnant, seven gave birth to healthy babies, two of the patients aborted in the first trimester. Four women are still in later stages of pregnancy. Galactorrhea disappeared in 56% of the patients, being markedly inhibited in the remaining ones. In two cases, microadenoma disappeared after treatment, and in those after surgery the postoperative findings were decreased, in one patients there is no alteration in the pathology. Side effects were seen in 34% of the patients, being mostly mild in nature, and including in most cases nausea, headache and stomach pain. The complaints were transient, receding after prolonged treatment.

[Surgical treatment of functional disorders of the esophagus in the aged]. / Zur Problematik der chirurgischen Behandlung von Funktionsstörungen der Speiseröhre im Alter.

From 1948 to 1980, 747 patients with functional disorders of the esophagus were operated on at the First Department of Surgery of the Medical Faculty, Palacky University in Olomouc. In 177 (24%) of them, the intervention was performed at an older age. The gerontosurgical problem was especially evident in patients with esophageal diverticula of whom 40 to 51.1% were older than 60 years. In patients with paraesophageal and mixed hiatal hernias, it was 45%. However, in very complicated cases of achalasia and reflux diseases, it was also often necessary to operate older patients. The applicability of some surgical techniques and tactics in older patients has been discussed.