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3.
Hum Genet ; 57(4): 371-5, 1981.
Article in English | MEDLINE | ID: mdl-6169619

ABSTRACT

A family has been observed which a gene for heterocellular hereditary persistence of fetal hemoglobin (HPFH), probably identical to that previously described as Swiss type HPFH, has been inherited together with beta-thalassemia. The interaction of these two genes resulted in beta-thalassemia heterozygotes with unusually high levels of fetal hemoglobin (3.6-6.15), heterogeneously distributed. Globin synthesis studies showed a similar degree of chain imbalance in the heterocellular HPFH-beta thalassemia compound heterozygotes and in the heterozygous beta-thalassemia member of the family. On the basis of the pattern of genetic transmission of these two characters it can be concluded that the HPFH determinant does not behave as an allele of the gamma beta delta complex.


Subject(s)
Fetal Hemoglobin/genetics , Thalassemia/genetics , Adolescent , Adult , Child , Erythrocytes/metabolism , Female , Genetic Carrier Screening , Globins/biosynthesis , HLA Antigens/genetics , Humans , Male , Middle Aged , Pedigree , Phenotype
12.
Arch Fr Mal App Dig ; 56(9): 878-9, 1967 Sep.
Article in French | MEDLINE | ID: mdl-5623359

Subject(s)
Ascites , Aged , Humans , Lymphography , Male
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