ABSTRACT
UNLABELLED: Cardiovascular diseases are one the main causes of mortality all over world. Proper estimation and reduction of atherosclerosis risk factors are very important in both primary and secondary prevention of coronary heart disease (CHD). THE AIM: of our study was to estimate atherosclerosis risk factors profile in subjects, inhabitants of Lódz (Poland), with (group I) and without (group II) CHD. MATERIAL AND METHODS: Group I--196 patients (85 men and 111 women), aged 34-88 years (mean 63.3 +/- 10.1 years). Group II--170 subjects (87 men and 83 women), aged 24-82 years (mean 58.16 +/- 13.8 years) without CHD. RESULTS: Overweight or obesity was the most frequent CHD risk factor in the examined population (74.49% in group I). Other risk factor in this group were: increased total cholesterol level (65.08%), hypertension (51,53%), smoking (40.31%), diabetes (24.08%). In group II overweight or obesity was observed in 60% patients, smoking--48.82%, elevated total cholesterol level--43.53%, hypertension--40.24% and diabetes--16.98%. CONCLUSION: Our study have demonstrated that realisation of primary and secondary prevention principles in Lódz population is insufficient.
Subject(s)
Coronary Artery Disease/epidemiology , Coronary Artery Disease/prevention & control , Preventive Health Services/supply & distribution , Adult , Aged , Aged, 80 and over , Catchment Area, Health , Cholesterol/blood , Coronary Artery Disease/blood , Female , Humans , Male , Middle Aged , Poland/epidemiology , Population Surveillance/methods , Risk FactorsABSTRACT
THE AIM: Evaluation of the knowledge on CHD risk factors in selected Lódz population was made. MATERIAL AND METHODS: Realization of primary and secondary CHD prevention principles was assessed. RESULTS: Over 20% of patients with CHD and over 38% of subjects without CHD did not realize the prevention principles. Hypolipemic therapy was effective only in 44.21% of patients with CHD and 35.9% of subjects without CHD. Antihypertensive therapy was successful in about 55% of patients with CHD and 35% of subjects without CHD. CONCLUSION: The results of our study have shown low effectiveness of both CHD prevention principles realization and hipolipemic and antihypertensive therapy in selected Lódz population.
Subject(s)
Coronary Disease/epidemiology , Coronary Disease/prevention & control , Preventive Health Services/supply & distribution , Adult , Aged , Aged, 80 and over , Anticholesteremic Agents/therapeutic use , Antihypertensive Agents/therapeutic use , Catchment Area, Health , Female , Humans , Hypercholesterolemia/drug therapy , Hypercholesterolemia/epidemiology , Hypertension/drug therapy , Hypertension/epidemiology , Male , Middle Aged , Poland/epidemiology , Population Surveillance/methods , Risk FactorsABSTRACT
The effect of fluvastatin and fenofibrate on O2-generation by neutrophils and MDA concentration in mixed hyperlipidaemic patients with stable angina was studied. Thirty-five patients (13 men and 22 women aged 40-77 years) were randomly divided into two groups. Group I comprised 20 patients who were administered fluvastatin 40 mg once daily at bedtime for 30 days. Group II consisted of 15 patients who were administered fenofibrate 200 mg once daily at bedtime for 30 days. The control group comprised 11 clinically healthy persons, aged 21-54 years. Neutrophil O2-generation was measured using Bellavite et al. method and MDA concentrations in plasma and erythrocytes were determined by Placer et al. method. It was shown that fluvastatin had no significant effect on O2-generation while fenofibrate increased its generation. None of the examined drugs caused changes of MDA concentrations in plasma and erythrocytes.
