ABSTRACT
Phenolic compounds are important functional bioactive substances distributed in various food plants. They have gained wide interest from researchers due to their multiple health benefits. There are two forms of phenolic compounds: free form and bound form. The latter is also called bound phenolics (BPs), which are found mainly in the cell wall and distributed in various tissues/organs of the plant body. They can either chemically bind to macromolecules and food matrixes or be physically entrapped in food matrixes and intact cells. Various isolation methods, including chemical, biological, and physical methods, have been employed to extract BPs from plants. BPs have been shown to have strong biological activities, including antioxidant, probiotic, anticancer, anti-inflammation, antiobesity, and antidiabetic effects as well as beneficial effects on central nervous system diseases. This review summarizes research findings on these topics to help in better understanding of BPs and provide comprehensive information on their health effects.
Subject(s)
Phenols , Plants, Edible , Antioxidants , Food , Phenols/analysis , Plant ExtractsABSTRACT
Trans-cinnamic acid (tCA) is a phenylpropenoic acid, which occurs naturally in a number of plants. In this study, the anti-obese effects of tCA were evaluated in oleic acid (OA)-induced HepG2 cells and high fat diet (HFD)-fed mice. The results showed tCA treatment significantly decreased lipid accumulation in HepG2 cells exposed to OA. Furthermore, administration of tCA (40 mg/kg/day) curbed body weight gains, reduced liver and adipose tissue weight, and ameliorated hepatic steatosis and adipose hypertrophy in mice fed with HFD. In addition, significant decrease in plasma levels of TG, TC and LDL-C were also observed in HFD-fed mice with tCA treatment. Collectively, tCA may play a vital role in preventing and treating diet induced obesity.
Subject(s)
Anti-Obesity Agents/therapeutic use , Cinnamates/therapeutic use , Fatty Liver/drug therapy , Animals , Body Weight/drug effects , Cinnamates/chemistry , Diet, High-Fat , Dietary Supplements , Eating/drug effects , Fatty Liver/pathology , Hep G2 Cells , Humans , Liver/pathology , Male , Mice, Inbred C57BL , Organ Size/drug effects , StereoisomerismABSTRACT
To evaluate the anti-obesity effects of chlorogenic acid (CGA), the mice were fed a high-fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD-induced gut microbiota dysbiosis, including significantly inhibiting the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae, Erysipelotrichaceae, and raising the growth of Bacteroidaceae, Lactobacillaceae. Overall, the amelioration of HFD-induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD-induced obesity.
ABSTRACT
In this study, the antiobesity effects of n-butanol extract of lotus seeds (LBE) were evaluated in cultured 3T3-L1 preadipocytes and in high-fat diet (HFD)-fed mice. LBE decreased lipid contents in mature 3T3-L1 cells without obvious cytotoxicity. Meanwhile, LBE supplementation also led to weight loss and improved plasma lipid profiles in HFD-fed mice. Furthermore, LBE could activate AMP-activated protein kinase (AMPK) accompanied by down-regulation of lipogenesis related genes (PPARγ, aP2, LPL, C/EBPα, FAS, SREBP-1c) and up-regulation of lipolysis genes (adiponectin and PPARα) in vitro and in vivo. Collectively, our data demonstrated LBE possesses antiadipogenic and antilipogenic activities which are, at least partially, mediated by the activation of AMPK signaling pathways.
Subject(s)
AMP-Activated Protein Kinases/metabolism , Adipocytes/drug effects , Anti-Obesity Agents/administration & dosage , Lotus/chemistry , Obesity/drug therapy , Plant Extracts/administration & dosage , 3T3-L1 Cells , AMP-Activated Protein Kinases/genetics , Adipocytes/enzymology , Adipocytes/metabolism , Adipogenesis/drug effects , Animals , Anti-Obesity Agents/isolation & purification , CCAAT-Enhancer-Binding Protein-alpha/genetics , CCAAT-Enhancer-Binding Protein-alpha/metabolism , Diet, High-Fat/adverse effects , Humans , Lipid Metabolism/drug effects , Lipogenesis/drug effects , Male , Mice , Mice, Inbred ICR , Obesity/genetics , Obesity/metabolism , Obesity/physiopathology , PPAR gamma/genetics , PPAR gamma/metabolism , Plant Extracts/isolation & purification , Seeds/chemistry , Sterol Regulatory Element Binding Protein 1/genetics , Sterol Regulatory Element Binding Protein 1/metabolismABSTRACT
This study was conducted to assess the potential application of ultrasonic treatment to enhance the tenderness of whelk (Buccinum undatum) meat. The optimum ultrasonic conditions for the maximum tenderization effect were determined using response surface methodology by a three-level factorial Box-Behnken design for the optimization of three variables. The optimum conditions for the three variables found were as follows: ultrasound power at 200 W, treatment time for 9.6 min, and temperature at 45°C. The resulted tenderization effect was comparable to traditional enzymatic methods. Furthermore, disruption of muscle microstructure was observed in the ultrasonic-treated whelk meat by scanning electron microscopy, while evaluations on physicochemical properties indicated the ultrasonic treatment has no significant undesirable effects on the quality of whelk meat including pH, water-holding capacity, and lipid oxidation. In conclusion, this study showed the feasibility of ultrasonic treatment as a promising tenderization method for whelk meat without detrimental effects on its quality.